Search Results - "Becker, Susen"

LC–MS-based metabolomics in the clinical laboratory by Becker, Susen, Kortz, Linda, Helmschrodt, Christin, Thiery, Joachim, Ceglarek, Uta

“…The analysis of metabolites in human body fluids remains a challenge because of their chemical diversity and dynamic concentration range. Liquid chromatography…”
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Sensitive and simultaneous quantification of 16 neurotransmitters and metabolites in murine microdialysate by fast liquid chromatography-tandem mass spectrometry by Becker, Susen, Schulz, Anja, Kreyer, Sophia, Dreßler, Jan, Richter, Angelika, Helmschrodt, Christin

“…The sensitive and simultaneous measurement of multiple neurotransmitters in microdialysate (MD) of freely moving mice is a prerequisite to study neurochemical…”
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High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression by Feuerborn, Renata, Becker, Susen, Poti, Francesco, Nagel, Petra, Brodde, Martin, Schmidt, Harmut, Christoffersen, Christina, Ceglarek, Uta, Burkhardt, Ralph, Nofer, Jerzy-Roch

“…Abstract Background and aims Macrophage apoptosis is critically involved in atherosclerosis. We here examined the effect of anti-atherogenic high density…”
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Plasma Amino Acid Concentrations Predict Mortality in Patients with End-Stage Liver Disease by Kinny-Köster, Benedict, Bartels, Michael, Becker, Susen, Scholz, Markus, Thiery, Joachim, Ceglarek, Uta, Kaiser, Thorsten

“…The liver plays a key role in amino acid metabolism. In former studies, a ratio between branched-chain and aromatic amino acids (Fischer's ratio) revealed…”
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Low PCSK9 levels are correlated with mortality in patients with end-stage liver disease by Schlegel, Valentin, Treuner-Kaueroff, Theresa, Seehofer, Daniel, Berg, Thomas, Becker, Susen, Ceglarek, Uta, Thiery, Joachim, Kaiser, Thorsten

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in the cholesterol metabolism and is synthesized by the liver. It interacts with the…”
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Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis by Becker, Susen, Kinny-Köster, Benedict, Bartels, Michael, Scholz, Markus, Seehofer, Daniel, Berg, Thomas, Engelmann, Cornelius, Thiery, Joachim, Ceglarek, Uta, Kaiser, Thorsten

“…The association of circulating sphingosine-1-phosphate (S1P), a bioactive lipid involved in various cellular processes, and related metabolites such as…”
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Evaluation of a Novel Commercial Assay for the Determination of Cyclosporine A, Tacrolimus, Sirolimus, and Everolimus by Liquid Chromatography―Tandem Mass Spectrometric Assay by BECKER, Susen, THIERY, Joachim, CEGLAREK, Uta

“…The aim of this study was the evaluation of the first commercially available in-vitro diagnostic (IVD)- mass spectrometric immunosuppressant assay from…”
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Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood by Burkhardt, Ralph, Kirsten, Holger, Beutner, Frank, Holdt, Lesca M, Gross, Arnd, Teren, Andrej, Tönjes, Anke, Becker, Susen, Krohn, Knut, Kovacs, Peter, Stumvoll, Michael, Teupser, Daniel, Thiery, Joachim, Ceglarek, Uta, Scholz, Markus

“…Profiling amino acids and acylcarnitines in whole blood spots is a powerful tool in the laboratory diagnosis of several inborn errors of metabolism. Emerging…”
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Effect of biobanking conditions on short-term stability of biomarkers in human serum and plasma by Zander, Johannes, Bruegel, Mathias, Kleinhempel, Alisa, Becker, Susen, Petros, Sirak, Kortz, Linda, Dorow, Juliane, Kratzsch, Jürgen, Baber, Ronny, Ceglarek, Uta, Thiery, Joachim, Teupser, Daniel

“…Liquid biobanking is an important tool for laboratory diagnostics in routine settings and clinical studies. However, the current knowledge about adequate…”
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Clinical and lifestyle related factors influencing whole blood metabolite levels – A comparative analysis of three large cohorts by Beuchel, Carl, Becker, Susen, Dittrich, Julia, Kirsten, Holger, Toenjes, Anke, Stumvoll, Michael, Loeffler, Markus, Thiele, Holger, Beutner, Frank, Thiery, Joachim, Ceglarek, Uta, Scholz, Markus

“…Human blood metabolites are influenced by a number of lifestyle and environmental factors. Identification of these factors and the proper quantification of…”
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Preanalytical Investigation of Polyunsaturated Fatty Acids and Eicosanoids in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry by Dorow, Juliane, Becker, Susen, Kortz, Linda, Thiery, Joachim, Hauschildt, Sunna, Ceglarek, Uta

“…Preanalytical variables have a great impact on sample matrices and are a source of laboratory errors. The effect of cryobanking, which is gaining great…”
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Serum Enterolactone and Prognosis of Postmenopausal Breast Cancer by BUCK, Katharina, VRIELING, Alina, ZAINEDDIN, Aida Karina, BECKER, Susen, HÜSING, Anika, KAAKS, Rudolf, LINSEISEN, Jakob, FLESCH-JANYS, Dieter, CHANG-CLAUDE, Jenny

“…Lignans--plant-derived compounds with estrogen-dependent and -independent anticarcinogenic properties--have been associated with postmenopausal breast cancer…”
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Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: a nested case-control study by James, Rebecca E, Lukanova, Annekatrin, Dossus, Laure, Becker, Susen, Rinaldi, Sabina, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Mesrine, Sylvie, Engel, Pierre, Clavel-Chapelon, Françoise, Chang-Claude, Jenny, Vrieling, Alina, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Rodríguez, Laudina, Buckland, Genevieve, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Bueno-de-Mesquita, Bas, Ros, Martine M, van Gils, Carla H, Peeters, Petra H, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J, Allen, Naomi E, Romieu, Isabelle, Siddiq, Afshan, Cox, David, Riboli, Elio, Kaaks, Rudolf

“…Prediagnostic endogenous sex steroid hormone levels have well established associations with overall risk of breast cancer. While evidence toward the existence…”
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Preanalytical standardization of sphingosine-1-phosphate, sphinganine-1-phosphate and sphingosine analysis in human plasma by liquid chromatography–tandem mass spectrometry by Ceglarek, Uta, Dittrich, Julia, Helmschrodt, Christin, Wagner, Kristin, Nofer, Jerzy-Roch, Thiery, Joachim, Becker, Susen

“…Preanalytical standardization is required for a reliable quantification of the signaling molecules sphingosine-1-phosphate (S1P), sphinganine-1-phosphate…”
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Serum enterolactone and postmenopausal breast cancer risk by estrogen, progesterone and herceptin 2 receptor status by Zaineddin, Aida Karina, Vrieling, Alina, Buck, Katharina, Becker, Susen, Linseisen, Jakob, Flesch-Janys, Dieter, Kaaks, Rudolf, Chang-Claude, Jenny

“…Lignans are a group of estrogenic compounds present in plants. Several epidemiological studies proposed that lignans may protect against breast cancer by…”
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Cholesterol esterification in plasma as a biomarker for liver function and prediction of mortality by Kaiser, Thorsten, Kinny-Köster, Benedict, Bartels, Michael, Berg, Thomas, Scholz, Markus, Engelmann, Cornelius, Seehofer, Daniel, Becker, Susen, Ceglarek, Uta, Thiery, Joachim

“…Advanced stages of liver cirrhosis lead to a dramatically increased mortality. For valid identification of these patients suitable biomarkers are essential…”
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Impact of clozapine, N-desmethylclozapine and chlorpromazine on thromboxane production in vitro by Himmerich, Hubertus, Schmidt, Luise, Becker, Susen, Kortz, Linda, Schonherr, Jeremias, Mergl, Roland, Bauer, Katrin, Sack, Ulrich, Sheldrick, Abigail J, Thiery, Joachim, Ceglarek, Uta

“…Thromboxane A2 (TxA2) and the activation of its receptor have been shown to modulate vasoconstriction and platelet aggregation as well as dopaminergic and…”
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Development of a fast liquid chromatography-tandem mass spectrometry method for simultaneous quantification of neurotransmitters in murine microdialysate by Helmschrodt, Christin, Becker, Susen, Perl, Stefanie, Schulz, Anja, Richter, Angelika

“…The continuous measurement of multiple neurotransmitters in microdialysate of freely moving mice to study neurochemical changes in specific brain regions…”
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Fast liquid chromatography–quadrupole linear ion trap-mass spectrometry analysis of polyunsaturated fatty acids and eicosanoids in human plasma by Kortz, Linda, Dorow, Juliane, Becker, Susen, Thiery, Joachim, Ceglarek, Uta

“…•Separation of 7 PUFAs and 94 oxidized metabolites by fast chromatography in 7min.•Quantitation via scheduled Multiple Reaction Monitoring in quadrupole…”
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LC-MS/MS Analysis of Triglycerides in Blood-Derived Samples by Reinicke, Madlen, Becker, Susen, Ceglarek, Uta

“…The increasing interest in the analysis of triglyceride (TG) species and the individual fatty acid (FA) composition requires expeditious and reliable…”
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