Search Results - "Becker, Kevin G"

LincRNA-p21 Suppresses Target mRNA Translation by Yoon, Je-Hyun, Abdelmohsen, Kotb, Srikantan, Subramanya, Yang, Xiaoling, Martindale, Jennifer L., De, Supriyo, Huarte, Maite, Zhan, Ming, Becker, Kevin G., Gorospe, Myriam

“…Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21…”
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Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes by Freeman, David W, Noren Hooten, Nicole, Eitan, Erez, Green, Jamal, Mode, Nicolle A, Bodogai, Monica, Zhang, Yongqing, Lehrmann, Elin, Zonderman, Alan B, Biragyn, Arya, Egan, Josephine, Becker, Kevin G, Mattson, Mark P, Ejiogu, Ngozi, Evans, Michele K

“…Type 2 diabetes is a chronic age-associated degenerative metabolic disease that reflects relative insulin deficiency and resistance. Extracellular vesicles…”
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The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet by Mitchell, Sarah J., Martin-Montalvo, Alejandro, Mercken, Evi M., Palacios, Hector H., Ward, Theresa M., Abulwerdi, Gelareh, Minor, Robin K., Vlasuk, George P., Ellis, James L., Sinclair, David A., Dawson, John, Allison, David B., Zhang, Yongqing, Becker, Kevin G., Bernier, Michel, de Cabo, Rafael

“…The prevention or delay of the onset of age-related diseases prolongs survival and improves quality of life while reducing the burden on the health care…”
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Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells by Bodogai, Monica, O'Connell, Jennifer, Kim, Ki, Kim, Yoo, Moritoh, Kanako, Chen, Chen, Gusev, Fedor, Vaughan, Kelli, Shulzhenko, Natalia, Mattison, Julie A, Lee-Chang, Catalina, Chen, Weixuan, Carlson, Olga, Becker, Kevin G, Gurung, Manoj, Morgun, Andrey, White, James, Meade, Theresa, Perdue, Kathy, Mack, Matthias, Ferrucci, Luigi, Trinchieri, Giorgio, de Cabo, Rafael, Rogaev, Evgeny, Egan, Josephine, Wu, Jiejun, Biragyn, Arya

“…Aging in humans is associated with increased hyperglycemia and insulin resistance (collectively termed IR) and dysregulation of the immune system. However, the…”
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Mannose Receptor Modulates Macrophage Polarization and Allergic Inflammation through miR-511-3p by Zhou, Yufeng, MD, PhD, Do, Danh C., PhD, Ishmael, Faoud T., MD, PhD, Squadrito, Mario Leonardo, PhD, Tang, Ho Man, MS, Tang, Ho Lam, PhD, Hsu, Man-Hsun, PhD, Qiu, Lipeng, PhD, Li, Changjun, MD, PhD, Zhang, Yongqing, PhD, Becker, Kevin G., PhD, Wan, Mei, PhD, Huang, Shau-Ku, PhD, Gao, Peisong, MD, PhD

“…Abstract Background Mannose receptor (MRC1/CD206) has been suggested to mediate allergic sensitization and asthma to multiple glyco-allergens, including…”
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Elongator and codon bias regulate protein levels in mammalian peripheral neurons by Goffena, Joy, Lefcort, Frances, Zhang, Yongqing, Lehrmann, Elin, Chaverra, Marta, Felig, Jehremy, Walters, Joseph, Buksch, Richard, Becker, Kevin G., George, Lynn

“…Familial dysautonomia (FD) results from mutation in IKBKAP/ELP1 , a gene encoding the scaffolding protein for the Elongator complex. This highly conserved…”
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Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway by Fang, Evandro F., Waltz, Tyler B., Kassahun, Henok, Lu, Qiping, Kerr, Jesse S., Morevati, Marya, Fivenson, Elayne M., Wollman, Bradley N., Marosi, Krisztina, Wilson, Mark A., Iser, Wendy B., Eckley, D. Mark, Zhang, Yongqing, Lehrmann, Elin, Goldberg, Ilya G., Scheibye-Knudsen, Morten, Mattson, Mark P., Nilsen, Hilde, Bohr, Vilhelm A., Becker, Kevin G.

“…Aging is a major international concern that brings formidable socioeconomic and healthcare challenges. Small molecules capable of improving the health of older…”
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MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs by Sun, Qinyu, Tripathi, Vidisha, Yoon, Je-Hyun, Singh, Deepak K, Hao, Qinyu, Min, Kyung-Won, Davila, Sylvia, Zealy, Richard W, Li, Xiao Ling, Polycarpou-Schwarz, Maria, Lehrmann, Elin, Zhang, Yongqing, Becker, Kevin G, Freier, Susan M, Zhu, Yuelin, Diederichs, Sven, Prasanth, Supriya G, Lal, Ashish, Gorospe, Myriam, Prasanth, Kannanganattu V

“…Abstract Long non-coding RNAs (lncRNAs) regulate vital biological processes, including cell proliferation, differentiation and development. A subclass of…”
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Longitudinal analysis reveals age-related changes in the T cell receptor repertoire of human T cell subsets by Sun, Xiaoping, Nguyen, Thomas, Achour, Achouak, Ko, Annette, Cifello, Jeffrey, Ling, Chen, Sharma, Jay, Hiroi, Toyoko, Zhang, Yongqing, Chia, Chee W, Wood Iii, William, Wu, Wells W, Zukley, Linda, Phue, Je-Nie, Becker, Kevin G, Shen, Rong-Fong, Ferrucci, Luigi, Weng, Nan-Ping

“…A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of pathogens and T cell repertoire size is believed to decline with…”
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MicroRNA expression and identification of putative miRNA targets in ovarian cancer by Dahiya, Neetu, Sherman-Baust, Cheryl A, Wang, Tian-Li, Davidson, Ben, Shih, Ie-Ming, Zhang, Yongqing, Wood, 3rd, William, Becker, Kevin G, Morin, Patrice J

“…MicroRNAs (miRNAs) represent a class of small non-coding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or…”
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Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes by Hutchison, Emmette R., Kawamoto, Elisa M., Taub, Dennis D., Lal, Ashish, Abdelmohsen, Kotb, Zhang, Yongqing, Wood III, William H., Lehrmann, Elin, Camandola, Simonetta, Becker, Kevin G., Gorospe, Myriam, Mattson, Mark P.

“…Inflammation is a common component of acute injuries of the central nervous system (CNS) such as ischemia, and degenerative disorders such as Alzheimer's…”
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AMPK Agonist AICAR Improves Cognition and Motor Coordination in Young and Aged Mice by Kobilo, Tali, Guerrieri, Davide, Zhang, Yongqing, Collica, Sarah C, Becker, Kevin G, van Praag, Henriette

“…Normal aging can result in a decline of memory and muscle function. Exercise may prevent or delay these changes. However, aging-associated frailty can preclude…”
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Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation by Zhao, Mingming, Joy, Jaimy, Zhou, Weiqiang, De, Supriyo, Wood, 3rd, William H, Becker, Kevin G, Ji, Hongkai, Sen, Ranjan

“…Transcription factor nuclear factor kappa B (NF-κB) regulates cellular responses to environmental cues. Many stimuli induce NF-κB transiently, making…”
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Tumor-Derived Thymic Stromal Lymphopoietin Expands Bone Marrow B-cell Precursors in Circulation to Support Metastasis by Ragonnaud, Emeline, Moritoh, Kanako, Bodogai, Monica, Gusev, Fedor, Garaud, Soizic, Chen, Chen, Wang, Xin, Baljinnyam, Tuvshintugs, Becker, Kevin G, Maul, Robert W, Willard-Gallo, Karen, Rogaev, Evgeny, Biragyn, Arya

“…Immature B cells in the bone marrow emigrate into the spleen during adult lymphopoiesis. Here, we report that emigration is shifted to earlier B-cell stages in…”
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Extremely Long-Range Chromatin Loops Link Topological Domains to Facilitate a Diverse Antibody Repertoire by Montefiori, Lindsey, Wuerffel, Robert, Roqueiro, Damian, Lajoie, Bryan, Guo, Changying, Gerasimova, Tatiana, De, Supriyo, Wood, William, Becker, Kevin G., Dekker, Job, Liang, Jie, Sen, Ranjan, Kenter, Amy L.

“…Early B cell development is characterized by large-scale Igh locus contraction prior to V(D)J recombination to facilitate a highly diverse Ig repertoire…”
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PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity by Yoon, Je-Hyun, De, Supriyo, Srikantan, Subramanya, Abdelmohsen, Kotb, Grammatikakis, Ioannis, Kim, Jiyoung, Kim, Kyoung Mi, Noh, Ji Heon, White, Elizabeth J. F., Martindale, Jennifer L., Yang, Xiaoling, Kang, Min-Ju, Wood, William H., Hooten, Nicole Noren, Evans, Michele K., Becker, Kevin G., Tripathi, Vidisha, Prasanth, Kannanganattu V., Wilson, Gerald M., Tuschl, Thomas, Ingolia, Nicholas T., Hafner, Markus, Gorospe, Myriam

“…Post-transcriptional gene regulation is robustly regulated by RNA-binding proteins (RBPs). Here we describe the collection of RNAs regulated by AUF1…”
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Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome by Fok, Wilson C, Chen, Yidong, Bokov, Alex, Zhang, Yiqiang, Salmon, Adam B, Diaz, Vivian, Javors, Martin, Wood, 3rd, William H, Zhang, Yongqing, Becker, Kevin G, Pérez, Viviana I, Richardson, Arlan

“…Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality…”
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Methamphetamine causes differential alterations in gene expression and patterns of histone acetylation/hypoacetylation in the rat nucleus accumbens by Martin, Tracey A, Jayanthi, Subramaniam, McCoy, Michael T, Brannock, Christie, Ladenheim, Bruce, Garrett, Tiffany, Lehrmann, Elin, Becker, Kevin G, Cadet, Jean Lud

“…Methamphetamine (METH) addiction is associated with several neuropsychiatric symptoms. Little is known about the effects of METH on gene expression and…”
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A double blind placebo controlled randomized trial of the effect of acute uric acid changes on inflammatory markers in humans: A pilot study by Tanaka, Toshiko, Milaneschi, Yuri, Zhang, Yongqing, Becker, Kevin G, Zukley, Linda, Ferrucci, Luigi

“…Uric acid has been linked with increased risk of chronic disease such as cardiovascular disease and this association has been attributed to a pro-inflammatory…”
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The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up‐regulation by Liu, Dong, Zhang, Yongqing, Gharavi, Robert, Park, Hee Ra, Lee, Jaewon, Siddiqui, Sana, Telljohann, Richard, Nassar, Matthew R., Cutler, Roy G., Becker, Kevin G., Mattson, Mark P.

“…Mitochondrial metabolism is highly responsive to nutrient availability and ongoing activity in neuronal circuits. The molecular mechanisms by which brain cells…”
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