Search Results - "Becker, Jason R."

Fulminant Myocarditis with Combination Immune Checkpoint Blockade by Johnson, Douglas B, Balko, Justin M, Compton, Margaret L, Chalkias, Spyridon, Gorham, Joshua, Xu, Yaomin, Hicks, Mellissa, Puzanov, Igor, Alexander, Matthew R, Bloomer, Tyler L, Becker, Jason R, Slosky, David A, Phillips, Elizabeth J, Pilkinton, Mark A, Craig-Owens, Laura, Kola, Nina, Plautz, Gregory, Reshef, Daniel S, Deutsch, Jonathan S, Deering, Raquel P, Olenchock, Benjamin A, Lichtman, Andrew H, Roden, Dan M, Seidman, Christine E, Koralnik, Igor J, Seidman, Jonathan G, Hoffman, Robert D, Taube, Janis M, Diaz, Luis A, Anders, Robert A, Sosman, Jeffrey A, Moslehi, Javid J

“…Fatal autoimmune myocarditis with rhabdomyolysis and refractory arrhythmias developed in two patients treated with a combination of anti–CTLA-4 and anti–PD-1…”
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Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes by Fenix, Aidan M, Neininger, Abigail C, Taneja, Nilay, Hyde, Karren, Visetsouk, Mike R, Garde, Ryan J, Liu, Baohong, Nixon, Benjamin R, Manalo, Annabelle E, Becker, Jason R, Crawley, Scott W, Bader, David M, Tyska, Matthew J, Liu, Qi, Gutzman, Jennifer H, Burnette, Dylan T

“…The sarcomere is the contractile unit within cardiomyocytes driving heart muscle contraction. We sought to test the mechanisms regulating actin and myosin…”
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Replication Stress Response Modifies Sarcomeric Cardiomyopathy Remodeling by Pal, Soumojit, Nixon, Benjamin R., Glennon, Michael S., Shridhar, Puneeth, Satterfield, Sidney L., Su, Yan Ru, Becker, Jason R.

“…Background Sarcomere gene mutations lead to cardiomyocyte hypertrophy and pathological myocardial remodeling. However, there is considerable phenotypic…”
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Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development by Becker, Jason R, Chatterjee, Sneha, Robinson, Tamara Y, Bennett, Jeffrey S, Panáková, Daniela, Galindo, Cristi L, Zhong, Lin, Shin, Jordan T, Coy, Shannon M, Kelly, Amy E, Roden, Dan M, Lim, Chee Chew, MacRae, Calum A

“…Organ development is a highly regulated process involving the coordinated proliferation and differentiation of diverse cellular populations. The pathways…”
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Sarcomere mutation negative hypertrophic cardiomyopathy is associated with ageing and obesity by de Feria, Alejandro E, Kott, Andrew E, Becker, Jason R

“…BackgroundDespite advances in our understanding of the genetic causes of hypertrophic cardiomyopathy (HCM), a large portion of this patient population do not…”
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Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish by Becker, Jason R, Deo, Rahul C, Werdich, Andreas A, Panàkovà, Daniela, Coy, Shannon, MacRae, Calum A

“…To assess the effects during cardiac development of mutations that cause human cardiomyopathy, we modeled a sarcomeric gene mutation in the embryonic…”
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Response by Shridhar et al to Letter Regarding Article, "MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy" by Shridhar, Puneeth, Pal, Soumojit, Clavere, Nicolas G, Becker, Jason R

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Ponatinib-induced cardiotoxicity: delineating the signalling mechanisms and potential rescue strategies by Singh, Anand P, Glennon, Michael S, Umbarkar, Prachi, Gupte, Manisha, Galindo, Cristi L, Zhang, Qinkun, Force, Thomas, Becker, Jason R, Lal, Hind

“…Abstract Aims Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of chronic myelogenous leukaemia (CML). However, cardiotoxicity of these…”
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MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy by Shridhar, Puneeth, Glennon, Michael S, Pal, Soumojit, Waldron, Christina J, Chetkof, Ethan J, Basak, Payel, Clavere, Nicolas G, Banerjee, Dipanjan, Gingras, Sebastien, Becker, Jason R

“…Microvasculature dysfunction is a common finding in pathologic remodeling of the heart and is thought to play an important role in the pathogenesis of…”
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Alterations in sarcomere function modify the hyperplastic to hypertrophic transition phase of mammalian cardiomyocyte development by Nixon, Benjamin R, Williams, Alexandra F, Glennon, Michael S, de Feria, Alejandro E, Sebag, Sara C, Baldwin, H Scott, Becker, Jason R

“…It remains unclear how perturbations in cardiomyocyte sarcomere function alter postnatal heart development. We utilized murine models that allowed manipulation…”
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Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signalling by Hall, Eric J, Pal, Soumojit, Glennon, Michael S, Shridhar, Puneeth, Satterfield, Sidney L, Weber, Beth, Zhang, Qinkun, Salama, Guy, Lal, Hind, Becker, Jason R

“…Abstract Aims The cardiac natriuretic peptides [atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP)] are important regulators of…”
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Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial by Ho, Carolyn Y., Day, Sharlene M., Axelsson, Anna, Russell, Mark W., Zahka, Kenneth, Lever, Harry M., Pereira, Alexandre C., Colan, Steven D., Margossian, Renee, Murphy, Anne M., Canter, Charles, Bach, Richard G., Wheeler, Matthew T., Rossano, Joseph W., Owens, Anjali T., Bundgaard, Henning, Benson, Lee, Mestroni, Luisa, Taylor, Matthew R. G., Patel, Amit R., Wilmot, Ivan, Thrush, Philip, Vargas, Jose D., Soslow, Jonathan H., Becker, Jason R., Seidman, Christine E., Lakdawala, Neal K., Cirino, Allison L., Burns, Kristin M., McMurray, John J. V., MacRae, Calum A., Solomon, Scott D., Orav, E. John, Braunwald, Eugene

“…Hypertrophic cardiomyopathy (HCM) is often caused by pathogenic variants in sarcomeric genes and characterized by left ventricular (LV) hypertrophy, myocardial…”
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A Comparative Study of Single-pulse and Double-pulse Laser-Induced Breakdown Spectroscopy with Uranium-containing Samples by Skrodzki, Patrick J., Becker, Jason R., Diwakar, Prasoon K., Harilal, Sivanandan S., Hassanein, Ahmed

“…Laser-induced breakdown spectroscopy (LIBS) holds potential advantages in special nuclear material (SNM) sensing and nuclear forensics, which require rapid…”
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Quality of Life and Exercise Capacity in Early Stage and Subclinical Hypertrophic Cardiomyopathy: A Secondary Analysis of the VANISH Trial by Ireland, Catherine G, Burstein, Danielle S, Day, Sharlene M, Axelsson Raja, Anna, Russell, Mark W, Zahka, Kenneth G, Pereira, Alexandre, Canter, Charles E, Bach, Richard G, Wheeler, Matthew T, Rossano, Joseph W, Owens, Anjali T, Bundgaard, Henning, Mestroni, Luisa, Taylor, Matthew R G, Patel, Amit R, Wilmot, Ivan, Soslow, Jonathan H, Becker, Jason R, Giverts, Ilya, Orav, E John, Claggett, Brian, Lin, Kimberly Y, Ho, Carolyn Y

“…The health-related quality of life (HRQOL) and cardiopulmonary exercise testing (CPET) performance of individuals with subclinical and early stage hypertrophic…”
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Nuclear localized Raf1 isoform alters DNA‐dependent protein kinase activity and the DNA damage response by Nixon, Benjamin R., Sebag, Sara C., Glennon, Michael S., Hall, Eric J., Kounlavong, Emily S., Freeman, Michael L., Becker, Jason R.

“…ABSTRACT Raf1/c‐Raf is a well‐characterized serine/threonine–protein kinase that links Ras family members with the MAPK/ERK signaling cascade. We have…”
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In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling by Becker, Jason R., Robinson, Tamara Y., Sachidanandan, Chetana, Kelly, Amy E., Coy, Shannon, Peterson, Randall T., MacRae, Calum A.

“…Aims Despite increased understanding of the fundamental biology regulating cardiomyocyte hypertrophy and heart failure, it has been challenging to find novel…”
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Transforming Growth Factor-β Analysis of the VANISH Trial Cohort by Kim, Yuri, Mastali, Mitra, Van Eyk, Jennifer E., Orav, E. John, Vissing, Christoffer R., Day, Sharlene M., Axelsson Raja, Anna, Russell, Mark W., Zahka, Kenneth, Lever, Harry M., Pereira, Alexandre C., Murphy, Anne M., Canter, Charles, Bach, Richard G., Wheeler, Matthew T., Rossano, Joseph W., Owens, Anjali T., Bundgaard, Henning, Benson, Lee, Mestroni, Luisa, Taylor, Matthew R.G., Patel, Amit R., Wilmot, Ivan, Thrush, Philip, Soslow, Jonathan H., Becker, Jason R., Seidman, Christine E., Ho, Carolyn Y.

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Whole Exome Sequencing Identifies a Causal RBM20 Mutation in a Large Pedigree With Familial Dilated Cardiomyopathy by Wells, Quinn S., Becker, Jason R., Su, Yan R., Mosley, Jonathan D., Weeke, Peter, D’Aoust, Laura, Ausborn, Natalie L., Ramirez, Andrea H., Pfotenhauer, Jean P., Naftilan, Allen J., Markham, Larry, Exil, Vernat, Roden, Dan M., Hong, Charles C.

“…BACKGROUND—Whole exome sequencing is a powerful technique for Mendelian disease gene discovery. However, variant prioritization remains a challenge. We applied…”
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Cardiac Remodeling in Subclinical Hypertrophic Cardiomyopathy: The VANISH Randomized Clinical Trial by Vissing, Christoffer Rasmus, Axelsson Raja, Anna, Day, Sharlene M, Russell, Mark W, Zahka, Kenneth, Lever, Harry M, Pereira, Alexandre C, Colan, Steven D, Margossian, Renee, Murphy, Anne M, Canter, Charles, Bach, Richard G, Wheeler, Matthew T, Rossano, Joseph W, Owens, Anjali T, Benson, Lee, Mestroni, Luisa, Taylor, Matthew R G, Patel, Amit R, Wilmot, Ivan, Thrush, Philip, Soslow, Jonathan H, Becker, Jason R, Seidman, Christine E, Lakdawala, Neal K, Cirino, Allison L, McMurray, John J V, MacRae, Calum A, Solomon, Scott D, Bundgaard, Henning, Orav, E John, Ho, Carolyn Y

“…Valsartan has shown promise in attenuating cardiac remodeling in patients with early-stage sarcomeric hypertrophic cardiomyopathy (HCM). Genetic testing can…”
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MULTIPARITY ADVERSELY IMPACTS MYOCARDIAL REMODELING IN A MURINE SARCOMERIC CARDIOMYOPATHY MODEL by Shridhar, Puneeth, Glennon, Michael S., Pal, Soumojit, Satterfield, Sidney L., Becker, Jason R.

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