Search Results - "Beck‐Sickinger, A G"

Central vaspin administration acutely reduces food intake and has sustained blood glucose-lowering effects by Klöting, N., Kovacs, P., Kern, M., Heiker, J. T., Fasshauer, M., Schön, M. R., Stumvoll, M., Beck-Sickinger, A. G., Blüher, M.

“…Aims/hypothesis Vaspin (visceral adipose tissue-derived serpin) was first identified as an adipokine in a rat model of type 2 diabetes, in which it is…”
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High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice by Thieme, V, Jolly, N, Madsen, A N, Bellmann‐Sickert, K, Schwartz, T W, Holst, B, Cox, H M, Beck‐Sickinger, A G

“…Background and Purpose Human pancreatic polypeptide (hPP) is known to suppress appetite and food intake, thereby representing a potential therapeutic approach…”
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Pancreatic polypeptide and its central Y4 receptors are essential for cued fear extinction and permanent suppression of fear by Verma, D, Hörmer, B, Bellmann‐Sickert, K, Thieme, V, Beck‐Sickinger, A G, Herzog, H, Sperk, G, Tasan, R O

“…Background and purpose Avoiding danger and finding food are closely related behaviours that are essential for surviving in a natural environment. Growing…”
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Biosynthesis of peptide hormones derived from precursor sequences by von Eggelkraut-Gottanka, R, Beck-Sickinger, A G

“…The release of hormones is subject to a complex and finely tuned regulation system. The biosynthesis plays a key role by specifically converting the prohormone…”
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Immunocytochemical localization of angiotensin II receptor subtypes and angiotensin II with monoclonal antibodies in the rat adrenal gland by Frei, N., Weissenberger, J., Beck-Sickinger, A.G., Höfliger, M., Weis, J., Imboden, H.

“…Angiotensin II (Ang II), a major regulator of cardiovascular function and body fluid homeostasis, mediates its biological actions via two subtypes of G…”
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The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats by Cabrele, C, Langer, M, Bader, R, Wieland, H A, Doods, H N, Zerbe, O, Beck-Sickinger, A G

“…The first Y(5) receptor-selective analog of neuropeptide Y (NPY), [Ala(31),Aib(32)]NPY, has been developed and biologically characterized. Using competition…”
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PYY3-36 as an anti-obesity drug target by Boggiano, M. M., Chandler, P. C., Oswald, K. D., Rodgers, R. J., Blundell, J. E., Ishii, Y., Beattie, A. H., Holch, P., Allison, D. B., Schindler, M., Arndt, K., Rudolf, K., Mark, M., Schoelch, C., Joost, H. G., Klaus, S., Thöne-Reineke, C., Benoit, S. C., Seeley, R. J., Beck-Sickinger, A. G., Koglin, N., Raun, K., Madsen, K., Wulff, B. S., Stidsen, C. E., Birringer, M., Kreuzer, O. J., Deng, X. Y., Whitcomb, D. C., Halem, H., Taylor, J., Dong, J., Datta, R., Culler, M., Ortmann, S., Castañeda, T. R., Tschöp, M.

“…Summary The neuropeptide Y (NPY)/peptide YY (PYY) system has been implicated in the physiology of obesity for several decades. More recently, Batterham et al…”
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Novel Peptide Conjugates for Tumor-Specific Chemotherapy by Langer, Michael, Kratz, Felix, Rothen-Rutishauser, Barbara, Wunderli-Allenspach, Heidi, Beck-Sickinger, Annette G

“…One of the major problems in cancer chemotherapy are the severe side effects that limit the dose of the anticancer drugs because of their unselectivity for…”
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Pancreatic polypeptide and its central Y 4 receptors are essential for cued fear extinction and permanent suppression of fear by Verma, D, Hörmer, B, Bellmann‐Sickert, K, Thieme, V, Beck‐Sickinger, A G, Herzog, H, Sperk, G, Tasan, R O

“…Background and purpose Avoiding danger and finding food are closely related behaviours that are essential for surviving in a natural environment. Growing…”
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Prenatal notch1 receptor blockade by protein delta homolog 1 (DLK1) modulates adipocyte size in vivo by Kilian, T M, Klöting, N, Blüher, M, Beck-Sickinger, A G

“…Introduction/Objectives: The protein delta homolog 1 (DLK1) has been reported to have an important role as inhibitor of adipogenesis. Understanding its mode of…”
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Calcitonin-derived carrier peptides by Neundorf, I, Beck-Sickinger, A G

“…The recent discovery of carrier peptides offers new opportunities to translocate several bioactive molecules into the cytoplasm. Previous studies have shown…”
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Semisynthesis and application of carboxyfluorescein-labelled biologically active human interleukin-8 by David, Ralf, Machova, Zuzana, Beck-Sickinger, Annette G

“…Human interleukin 8 (hIL-8), a neutrophil-activating and chemotactic cytokine, is known to play an important role in the pathogenesis of a large number of…”
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Antibodies to the protein core of the small cell lung cancer workshop antigen cluster‐w4 and to the leucocyte workshop antigen CD24 recognize the same short protein sequence leucine‐alanine‐proline by WEBER, E., LEHMANN, H. P., BECK‐SICKINGER, A. G., WAWRZYNCZAK, E. J., WAIBEL, R., FOLKERS, G., STAHEL, R. A.

“…SUMMARY We recently described the identity of the small cell lung cancer (SCLC) cluster‐w4 antigen and the human B cell differentiation marker CD24, a…”
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Manipulating Y receptor subtype activation of short neuropeptide Y analogs by introducing carbaboranes by Hofmann, S, Frank, R, Hey-Hawkins, E, Beck-Sickinger, A.G, Schmidt, P

“…Abstract Short selective neuropeptide Y (NPY) analogs are highly attractive because of their facile synthesis. Based on the reduced-size NPY analog [Pro30 ,…”
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Physiology: Does gut hormone PYY3-36 decrease food intake in rodents? by Tschop, M, Castaneda, T. R, Joost, H. G, Thone-Reineke, C, Ortmann, S, Klaus, S, Hagan, M. M, Chandler, P. C, Oswald, K. D, Benoit, S. C, Seeley, R. J, Kinzig, K. P, Moran, T. H, Beck-Sickinger, A. G, Koglin, N, Rodgers, R. J, Blundell, J. E, Ishii, Y, Beattie, A. H, Holch, P, Allison, D. B, Raun, K, Madsen, K, Wulff, B. S, Stidsen, C. E, Birringer, M, Kreuzer, O. J, Schindler, M, Arndt, K, Rudolf, K, Mark, M, Deng, X. Y, Withcomb, D. C, Halem, H, Taylor, J, Dong, J, Datta, R, Culler, M, Craney, S, Flora, D, Smiley, D, Heiman, M. L

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Radiometal targeted tumor diagnosis and therapy with peptide hormones by Zwanziger, D, Beck-Sickinger, A G

“…Radiometal labeled peptide hormones are promising tools for a new generation of radiopharmaceuticals, because their receptors frequently are overexpressed in…”
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A fast and inexpensive method for N-terminal fluorescein-labeling of peptides by Weber, Peter J.A, Bader, Jürgen E, Folkers, Gerd, Beck-Sickinger, Annette G

“…A new method has been developed to synthesize fluorescein labeled peptides, compounds of increasing importance in bioorganic chemistry, cell biology,…”
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From Micromolar to Nanomolar Affinity:  A Systematic Approach To Identify the Binding Site of CGRP at the Human Calcitonin Gene-Related Peptide 1 Receptor by Rist, Beate, Entzeroth, Michael, Beck-Sickinger, Annette G

“…CGRP Y0-28-37 is known as a selective CGRP1 receptor antagonist. In order to elucidate the essential requirements for its receptor interaction, we performed a…”
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The selective neuropeptide Y Y5 agonist [cPP1–7,NPY19–23,Ala31,Aib32,Gln34]hPP differently modulates emotional processes and body weight in the rat by Morales-Medina, J.C., Dominguez-Lopez, S., Gobbi, G., Beck-Sickinger, A.G., Quirion, R.

“…The neuropeptide Y (NPY) has been suggested to act as a major regulator of emotional processes and body weight. The full spectrum of biological effects of this…”
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ESAG 6 and 7 products of Trypanosoma brucei form a transferrin binding protein complex by Steverding, D, Stierhof, Y D, Chaudhri, M, Ligtenberg, M, Schell, D, Beck-Sickinger, A G, Overath, P

“…In Trypanosoma brucei, the gene for the expressed variant surface glycoprotein (VSG) is preceded by a series of open reading frames designated expression site…”
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