Search Results - "Beck, Katy E."

Isolation of prion with BSE properties from farmed goat by Spiropoulos, John, Lockey, Richard, Sallis, Rosemary E, Terry, Linda A, Thorne, Leigh, Holder, Thomas M, Beck, Katy E, Simmons, Marion M

“…Transmissible spongiform encephalopathies are fatal neurodegenerative diseases that include variant Creutzfeldt-Jakob disease in humans, scrapie in small…”
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Strain typing of classical scrapie by transgenic mouse bioassay using protein misfolding cyclic amplification to replace primary passage by Beck, Katy E, Thorne, Leigh, Lockey, Richard, Vickery, Christopher M, Terry, Linda A, Bujdoso, Raymond, Spiropoulos, John

“…According to traditional murine bioassay methodology, prions must be serially passaged within a new host before a stable phenotype, and therefore a strain, can…”
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Assessing the Susceptibility of Transgenic Mice Overexpressing Deer Prion Protein to Bovine Spongiform Encephalopathy by Vickery, Christopher M, Lockey, Richard, Holder, Thomas M, Thorne, Leigh, Beck, Katy E, Wilson, Christina, Denyer, Margaret, Sheehan, John, Marsh, Sarah, Webb, Paul R, Dexter, Ian, Norman, Angela, Popescu, Emma, Schneider, Amanda, Holden, Paul, Griffiths, Peter C, Plater, Jane M, Dagleish, Mark P, Martin, Stuart, Telling, Glenn C, Simmons, Marion M, Spiropoulos, John

“…Classifications Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Lesion Profiling at Primary Isolation in RIII Mice is Insufficient in Distinguishing BSE from Classical Scrapie by Beck, Katy E., Chaplin, Melanie, Stack, Michael, Sallis, Rosemary E., Simonini, Sarah, Lockey, Richard, Spiropoulos, John

“…Primary isolation of bovine spongiform encephalopathy (BSE) in RIII mice generates a lesion profile believed to be reproducible and distinct from that produced…”
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The interpretation of disease phenotypes to identify TSE strains following murine bioassay: characterisation of classical scrapie by Beck, Katy E, Vickery, Christopher M, Lockey, Richard, Holder, Thomas, Thorne, Leigh, Terry, Linda A, Denyer, Margaret, Webb, Paul, Simmons, Marion M, Spiropoulos, John

“…Mouse bioassay can be readily employed for strain typing of naturally occurring transmissible spongiform encephalopathy cases. Classical scrapie strains have…”
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Use of Murine Bioassay to Resolve Ovine Transmissible Spongiform Encephalopathy Cases Showing a Bovine Spongiform Encephalopathy Molecular Profile by Beck, Katy E., Sallis, Rosemary E., Lockey, Richard, Vickery, Christopher M., Béringue, Vincent, Laude, Hubert, Holder, Thomas M., Thorne, Leigh, Terry, Linda A., Tout, Anna C., Jayasena, Dhanushka, Griffiths, Peter C., Cawthraw, Saira, Ellis, Richard, Balkema-Buschmann, Anne, Groschup, Martin H., Simmons, Marion M., Spiropoulos, John

“…Two cases of unusual transmissible spongiform encephalopathy (TSE) were diagnosed on the same farm in ARQ/ARQ PrP sheep showing attributes of both bovine…”
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The interpretation of disease phenotypes to identify TSE strains in mice: characterisation of BSE using PrPSc distribution patterns in the brain by Corda, Erica, Beck, Katy E, Sallis, Rosemary E, Vickery, Christopher M, Denyer, Margaret, Webb, Paul R, Bellworthy, Susan J, Spencer, Yvonne I, Simmons, Marion M, Spiropoulos, John

“…In individual animals affected by transmissible spongiform encephalopathies, different disease phenotypes can be identified which are attributed to different…”
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The role of tissue transglutaminase in 1-methyl-4-phenylpyridinium (MPP +)-induced toxicity in differentiated human SH-SY5Y neuroblastoma cells by Beck, Katy E., De Girolamo, Luigi A., Griffin, Martin, Billett, E. Ellen

“…Tissue transglutaminase (TG2) can induce post-translational modification of proteins, resulting in protein cross-linking or incorporation of polyamines into…”
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L-BSE experimentally transmitted to sheep presents as a unique disease phenotype by Simmons, Marion M, Chaplin, Melanie J, Konold, Timm, Casalone, Cristina, Beck, Katy E, Thorne, Leigh, Everitt, Sharon, Floyd, Tobias, Clifford, Derek, Spiropoulos, John

“…Apart from prion protein genotype, the factors determining the host range and susceptiblity for specific transmissible spongiform encephalopathy agents remain…”
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Inactivation of H‐type and L‐type bovine spongiform encephalopathy following recommended autoclave decontamination procedures by Chapman, Gail E., Lockey, Richard, Beck, Katy E., Vickery, Chris, Arnold, Mark, Thorne, Leigh, Thorne, Jemma K., Walker, Sarah R., Keulen, Lucien, Casalone, Cristina, Griffiths, Peter C., Simmons, Marion M., Terry, Linda A., Spiropoulos, John

“…The resistance of H‐type and L‐type BSE prions to autoclaving under EU regulation conditions for specified risk material is unknown. We employed transgenic…”
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Incomplete inactivation of atypical scrapie following recommended autoclave decontamination procedures by Spiropoulos, John, Lockey, Richard, Beck, Katy E., Vickery, Chris, Holder, Thomas M., Thorne, Leigh, Arnold, Mark, Andreoletti, Olivier, Simmons, Marion M., Terry, Linda A.

“…Prions are highly resistant to the decontamination procedures normally used to inactivate conventional pathogens. This is a challenging problem not only in the…”
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Infectious titres of sheep scrapie and bovine spongiform encephalopathy agents cannot be accurately predicted from quantitative laboratory test results by GONZALEZ, Lorenzo, THORNE, Leigh, JEFFREY, Martin, MARTIN, Stuart, SPIROPOULOS, John, BECK, Katy E, LOCKEY, Richard W, VICKERY, Christopher M, HOLDER, Thomas, TERRY, Linda

“…It is widely accepted that abnormal forms of the prion protein (PrP) are the best surrogate marker for the infectious agent of prion diseases and, in practice,…”
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Selection of Distinct Strain Phenotypes in Mice Infected by Ovine Natural Scrapie Isolates Similar to CH1641 Experimental Scrapie by Vulin, Johann, Beck, Katy E, Bencsik, Anna, Lakhdar, Latefa, Spiropoulos, John, Baron, Thierry

“…ABSTRACTA few cases of transmissible spongiform encephalopathies in sheep have been described in France in which the protease-resistant prion protein (PrP)…”
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Comparison of the peak exercise response measured by the ramp and 1-min step cycle exercise protocols in patients with exertional dyspnea by Revill, Sue M, Beck, Katy E, Morgan, Mike D L

“…To compare the peak exercise response and determine the limits of agreement between the ramp and the 1-min step cycle protocols in a representative population…”
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Ovine PrP Genotype is Linked With Lesion Profile and Immunohistochemistry Patterns After Primary Transmission of Classical Scrapie to Wild-Type Mice by Beck, Katy E, Sallis, Rosemary E, Lockey, Richard, Simmons, Marion M, Spiropoulos, John

“…It is currently believed that primary transmission of classical scrapie to wild-type mice is inefficient and characterized by low attack rates and variable…”
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Disease characteristics of bovine spongiform encephalopathy following inoculation into mice via three different routes by Vickery, Christopher M., Beck, Katy E., Simmons, Marion M., Hawkins, Stephen A. C., Spiropoulos, John

“…Summary Mouse‐adapted transmissible spongiform encephalopathy (TSE) strains are routinely distinguished based on reproducible disease characteristics in a…”
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Assessment of the direct and indirect effects of MPP⁺ and dopamine on the human proteasome: implications for Parkinson's disease aetiology by Caneda-Ferrón, Begoña, De Girolamo, Luigi A, Costa, Teresa, Beck, Katy E, Layfield, Robert, Billett, E. Ellen

“…Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson's disease (PD), linked recently to…”
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The cysteine string protein multimeric complex by Swayne, Leigh Anne, Beck, Katy E., Braun, Janice E.A.

“…Cysteine string protein (CSPα) is a member of the cellular folding machinery that is located on regulated secretory vesicles. We have previously shown that…”
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Rdj2, a J protein family member, interacts with cellular prion PrP(C) by Beck, Katy E, Kay, Jason G, Braun, Janice E A

“…PrP(C) is a glycosylphosphatidylinositol (GPI) anchored glycoprotein of unknown function. Misfolding of normal cellular PrP(C) to the pathogenic PrP(Sc) is the…”
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RDJ2 (DNAJA2) Chaperones Neural G Protein Signaling Pathways by Rosales-Hernandez, Alma, Beck, Katy E., Zhao, Xiaoxi, Braun, Andrew P., Braun, Janice E. A.

“…A number of structurally divergent proteins with J domains, called J proteins, interact with and activate the ATPase of Hsp70s, thereby harnessing the ATPase…”
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