Search Results - "Beck, Heike"

Cx43 Promotes Endothelial Cell Migration and Angiogenesis via the Tyrosine Phosphatase SHP-2 by Mannell, Hanna, Kameritsch, Petra, Beck, Heike, Pfeifer, Alexander, Pohl, Ulrich, Pogoda, Kristin

“…The gap junction protein connexin 43 (Cx43) is associated with increased cell migration and to related changes of the actin cytoskeleton, which is mediated via…”
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Angiopoietin-2-induced blood–brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling by Gurnik, Stefanie, Devraj, Kavi, Macas, Jadranka, Yamaji, Maiko, Starke, Julia, Scholz, Alexander, Sommer, Kathleen, Di Tacchio, Mariangela, Vutukuri, Rajkumar, Beck, Heike, Mittelbronn, Michel, Foerch, Christian, Pfeilschifter, Waltraud, Liebner, Stefan, Peters, Kevin G., Plate, Karl H., Reiss, Yvonne

“…The homeostasis of the central nervous system is maintained by the blood–brain barrier (BBB). Angiopoietins (Ang-1/Ang-2) act as antagonizing molecules to…”
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Combined Deficiency in Glutathione Peroxidase 4 and Vitamin E Causes Multiorgan Thrombus Formation and Early Death in Mice by Wortmann, Markus, Schneider, Manuela, Pircher, Joachim, Hellfritsch, Juliane, Aichler, Michaela, Vegi, Naidu, Kölle, Pirkko, Kuhlencordt, Peter, Walch, Axel, Pohl, Ulrich, Bornkamm, Georg W, Conrad, Marcus, Beck, Heike

“…RATIONALE:Growing evidence indicates that oxidative stress contributes markedly to endothelial dysfunction. The selenoenzyme glutathione peroxidase 4 (Gpx4) is…”
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The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity by Kameritsch, Petra, Singer, Miriam, Nuernbergk, Christoph, Rios, Natalia, Reyes, Aníbal M., Schmidt, Kjestine, Kirsch, Julian, Schneider, Holger, Müller, Susanna, Pogoda, Kristin, Cui, Ruicen, Kirchner, Thomas, de Wit, Cor, Lange-Sperandio, Bärbel, Pohl, Ulrich, Conrad, Marcus, Radi, Rafael, Beck, Heike

“…The mitochondrial thioredoxin/peroxiredoxin system encompasses NADPH, thioredoxin reductase 2 (TrxR2), thioredoxin 2, and peroxiredoxins 3 and 5 (Prx3 and…”
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Dopaminergic neurons of system xc–‐deficient mice are highly protected against 6‐hydroxydopamine‐induced toxicity by Massie, Ann, Schallier, Anneleen, Kim, Seong Woong, Fernando, Ruani, Kobayashi, Sho, Beck, Heike, Bundel, Dimitri De, Vermoesen, Katia, Bannai, Shiro, Smolders, Ilse, Conrad, Marcus, Plesnila, Nikolaus, Sato, Hideyo, Michotte, Yvette

“…ABSTRACT Malfunctioning of system xc–, responsible for exchanging intracellular glutamate for extracellular cystine, can cause oxidative stress and…”
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Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation by PANKAJ KUMAR MANDAL, SCHNEIDER, Manuela, KÖLLE, Pirkko, KUHLENCORDT, Peter, FÖRSTER, Heidi, BECK, Heike, BORNKAMM, Georg W, CONRAD, Marcus

“…Tumor cells generate substantial amounts of reactive oxygen species (ROS), engendering the need to maintain high levels of antioxidants such as thioredoxin…”
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Endothelial Dysfunction, and A Prothrombotic, Proinflammatory Phenotype Is Caused by Loss of Mitochondrial Thioredoxin Reductase in Endothelium by Kirsch, Julian, Schneider, Holger, Pagel, Judith-Irina, Rehberg, Markus, Singer, Miriam, Hellfritsch, Juliane, Chillo, Omary, Schubert, Kai Michael, Qiu, Jiehua, Pogoda, Kristin, Kameritsch, Petra, Uhl, Bernd, Pircher, Joachim, Deindl, Elisabeth, Müller, Susanna, Kirchner, Thomas, Pohl, Ulrich, Conrad, Marcus, Beck, Heike

“…OBJECTIVE—Although the investigation on the importance of mitochondria-derived reactive oxygen species (ROS) in endothelial function has been gaining momentum,…”
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Extratubular Polymerized Uromodulin Induces Leukocyte Recruitment and Inflammation In Vivo by Immler, Roland, Lange-Sperandio, Bärbel, Steffen, Tobias, Beck, Heike, Rohwedder, Ina, Roth, Jonas, Napoli, Matteo, Hupel, Georg, Pfister, Frederik, Popper, Bastian, Uhl, Bernd, Mannell, Hanna, Reichel, Christoph A, Vielhauer, Volker, Scherberich, Jürgen, Sperandio, Markus, Pruenster, Monika

“…Uromodulin (UMOD) is produced and secreted by tubular epithelial cells. Secreted UMOD polymerizes (pUMOD) in the tubular lumen, where it regulates salt…”
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Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis by Hellfritsch, Juliane, Kirsch, Julian, Schneider, Manuela, Fluege, Tamara, Wortmann, Markus, Frijhoff, Jeroen, Dagnell, Markus, Fey, Theres, Esposito, Irene, Kölle, Pirkko, Pogoda, Kristin, Angeli, José Pedro Friedmann, Ingold, Irina, Kuhlencordt, Peter, Östman, Arne, Pohl, Ulrich, Conrad, Marcus, Beck, Heike

“…Mitochondrial thioredoxin reductase (Txnrd2) is a central player in the control of mitochondrial hydrogen peroxide (H2O2) abundance by serving as a direct…”
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Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function by Conrad, Marcus, Jakupoglu, Cemile, Moreno, Stéphanie G., Lippl, Stefanie, Banjac, Ana, Schneider, Manuela, Beck, Heike, Hatzopoulos, Antonis K., Just, Ursula, Sinowatz, Fred, Schmahl, Wolfgang, Chien, Kenneth R., Wurst, Wolfgang, Bornkamm, Georg W., Brielmeier, Markus

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Absence of Glutathione Peroxidase 4 Affects Tumor Angiogenesis through Increased 12/15-Lipoxygenase Activity by Schneider, Manuela, Wortmann, Markus, Mandal, Pankaj Kumar, Arpornchayanon, Warangkana, Jannasch, Katharina, Alves, Frauke, Strieth, Sebastian, Conrad, Marcus, Beck, Heike

“…The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert…”
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The Role of Bradykinin B1 and B2 Receptors for Secondary Brain Damage after Traumatic Brain Injury in Mice by Trabold, Raimund, Erös, Christian, Zweckberger, Klaus, Relton, Jane, Beck, Heike, Nussberger, Juerg, Müller-Esterl, Werner, Bader, Michael, Whalley, Eric, Plesnila, Nikolaus

“…Inflammatory mechanisms are known to contribute to the pathophysiology of traumatic brain injury (TBI). Since bradykinin is one of the first mediators…”
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The role of thioredoxin reductases in brain development by Soerensen, Jonna, Jakupoglu, Cemile, Beck, Heike, Förster, Heidi, Schmidt, Jörg, Schmahl, Wolfgang, Schweizer, Ulrich, Conrad, Marcus, Brielmeier, Markus

“…The thioredoxin-dependent system is an essential regulator of cellular redox balance. Since oxidative stress has been linked with neurodegenerative disease, we…”
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Direct Stimulation of Adult Neural Stem Cells In Vitro and Neurogenesis In Vivo by Vascular Endothelial Growth Factor by Schänzer, Anne, Wachs, Frank-Peter, Wilhelm, Daniel, Acker, Till, Cooper-Kuhn, Christiana, Beck, Heike, Winkler, Jürgen, Aigner, Ludwig, Plate, Karl H., Kuhn, H. Georg

“…Hypoxia as well as global and focal ischemia are strong activators of neurogenesis in the adult mammalian central nervous system. Here we show that the…”
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Egr-1 Regulates Expression of the Glial Scar Component Phosphacan in Astrocytes after Experimental Stroke by Beck, Heike, Semisch, Matthias, Culmsee, Carsten, Plesnila, Nikolaus, Hatzopoulos, Antonis K

“…Ischemic brain injury causes tissue damage and neuronal death. The deficits can often be permanent because adult neurons fail to regenerate. One barrier to…”
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Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor by Raab, Sabine, Beck, Heike, Gaumann, Andreas, Yüce, Ali, Gerber, Hans-Peter, Plate, Karl, Hammes, Hans-Peter, Ferrara, Napoleone, Breier, Georg

“…Vascular endothelial growth factor (VEGF) is essential for the differentiation of the primitive embryonic vascular system and has been implicated in the…”
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Expression of Angiopoietin-1, Angiopoietin-2, and Tie Receptors after Middle Cerebral Artery Occlusion in the Rat by Beck, Heike, Acker, Till, Wiessner, Christoph, Allegrini, Peter R., Plate, Karl H.

“…Vascular endothelial growth factor (VEGF), a key regulator of vasculogenesis and embryonic angiogenesis, was recently found to be up-regulated in an animal…”
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Participation of Bone Marrow-Derived Cells in Long-Term Repair Processes After Experimental Stroke by Beck, Heike, Voswinckel, Robert, Wagner, Shawn, Ziegelhoeffer, Tibor, Heil, Matthias, Helisch, Armin, Schaper, Wolfgang, Acker, Till, Hatzopoulos, Antonis K., Plate, Karl H.

“…Bone marrow-derived cells participate in remodeling processes of many ischemia-associated diseases, which has raised hopes for the use of bone marrow as a…”
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Angiogenesis after cerebral ischemia by Beck, Heike, Plate, Karl H.

“…Though the vascular system of the adult brain is extremely stable under normal baseline conditions, endothelial cells start to proliferate in response to brain…”
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice by Friedmann Angeli, Jose Pedro, Schneider, Manuela, Proneth, Bettina, Tyurina, Yulia Y., Tyurin, Vladimir A., Hammond, Victoria J., Herbach, Nadja, Aichler, Michaela, Walch, Axel, Eggenhofer, Elke, Basavarajappa, Devaraj, Rådmark, Olof, Kobayashi, Sho, Seibt, Tobias, Beck, Heike, Neff, Frauke, Esposito, Irene, Wanke, Rüdiger, Förster, Heidi, Yefremova, Olena, Heinrichmeyer, Marc, Bornkamm, Georg W., Geissler, Edward K., Thomas, Stephen B., Stockwell, Brent R., O’Donnell, Valerie B., Kagan, Valerian E., Schick, Joel A., Conrad, Marcus

“…Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour types, and in engineered cells overexpressing oncogenic RAS…”
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