Search Results - "Beck, H"

PLA2R and THSD7A: Disparate Paths to the Same Disease? by Beck, Jr, Laurence H

“…The phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) are the two major autoantigens in primary membranous nephropathy…”
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Satellite Remote Sensing for Water Resources Management: Potential for Supporting Sustainable Development in Data‐Poor Regions by Sheffield, J., Wood, E. F., Pan, M., Beck, H., Coccia, G., Serrat‐Capdevila, A., Verbist, K.

“…Water resources management (WRM) for sustainable development presents many challenges in areas with sparse in situ monitoring networks. The exponential growth…”
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Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations by Guarnerio, Jlenia, Bezzi, Marco, Jeong, Jong Cheol, Paffenholz, Stella V., Berry, Kelsey, Naldini, Matteo M., Lo-Coco, Francesco, Tay, Yvonne, Beck, Andrew H., Pandolfi, Pier Paolo

“…Chromosomal translocations encode oncogenic fusion proteins that have been proven to be causally involved in tumorigenesis. Our understanding of whether such…”
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Testing Dark Decays of Baryons in Neutron Stars by Baym, Gordon, Beck, D H, Geltenbort, Peter, Shelton, Jessie

“…The observation of neutron stars with masses greater than one solar mass places severe demands on any exotic neutron decay mode that could explain the…”
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Membranous nephropathy: from models to man by Beck, Jr, Laurence H, Salant, David J

“…As recently as 2002, most cases of primary membranous nephropathy (MN), a relatively common cause of nephrotic syndrome in adults, were considered idiopathic…”
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Membranous Nephropathy: A Journey From Bench to Bedside by Francis, Jean M., MD, Beck, Laurence H., MD, PhD, Salant, David J., MD

“…Lessons from an animal model that faithfully resembles human membranous nephropathy (MN) have informed our understanding of the pathogenesis of this…”
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Quantity Versus Quality of Anti–Phospholipase A2 Receptor 1 Autoantibodies in the Assessment of Clinical Outcome in Membranous Nephropathy: The Debate Continues by Beck, Laurence H.

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Membranous Nephropathy: Core Curriculum 2021 by Alsharhan, Loulwa, Beck, Laurence H.

“…The understanding and management of membranous nephropathy, a common cause of nephrotic syndrome that is more frequently encountered in adults than in…”
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The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy by Scherz-Shouval, Ruth, Santagata, Sandro, Mendillo, Marc L., Sholl, Lynette M., Ben-Aharon, Irit, Beck, Andrew H., Dias-Santagata, Dora, Koeva, Martina, Stemmer, Salomon M., Whitesell, Luke, Lindquist, Susan

“…Stromal cells within the tumor microenvironment are essential for tumor progression and metastasis. Surprisingly little is known about the factors that drive…”
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Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology by Watts, Andrew J B, Keller, Keith H, Lerner, Gabriel, Rosales, Ivy, Collins, A Bernard, Sekulic, Miroslav, Waikar, Sushrut S, Chandraker, Anil, Riella, Leonardo V, Alexander, Mariam P, Troost, Jonathan P, Chen, Junbo, Fermin, Damian, Yee, Jennifer L, Sampson, Matthew G, Beck, Jr, Laurence H, Henderson, Joel M, Greka, Anna, Rennke, Helmut G, Weins, Astrid

“…Failure of the glomerular filtration barrier, primarily by loss of slit diaphragm architecture, underlies nephrotic syndrome in minimal change disease. The…”
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Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy by Tomas, Nicola M, Beck, Laurence H, Meyer-Schwesinger, Catherine, Seitz-Polski, Barbara, Ma, Hong, Zahner, Gunther, Dolla, Guillaume, Hoxha, Elion, Helmchen, Udo, Dabert-Gay, Anne-Sophie, Debayle, Delphine, Merchant, Michael, Klein, Jon, Salant, David J, Stahl, Rolf A.K, Lambeau, Gérard

“…Idiopathic membranous nephropathy is associated with autoantibodies against the phospholipase A2 receptor (PLA2R1) in about 70% of patients. This study…”
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SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression by Gan, Wenjian, Dai, Xiangpeng, Lunardi, Andrea, Li, Zhen, Inuzuka, Hiroyuki, Liu, Pengda, Varmeh, Shoreh, Zhang, Jinfang, Cheng, Liang, Sun, Yin, Asara, John M., Beck, Andrew H., Huang, Jiaoti, Pandolfi, Pier Paolo, Wei, Wenyi

“…The ERG gene is fused to TMPRSS2 in approximately 50% of prostate cancers (PrCa), resulting in its overexpression. However, whether this is the sole mechanism…”
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Anti-Phospholipase A2 Receptor Antibody in Membranous Nephropathy by WEISONG QIN, BECK, Laurence H, CAIHONG ZENG, ZHAOHONG CHEN, SHIJUN LI, KE ZUO, SALANT, David J, ZHIHONG LIU

“…The M-type phospholipase A2 receptor (PLA2R) is a target autoantigen in adult idiopathic membranous nephropathy (MN), but the prevalence of autoantibodies…”
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M-Type Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy by Beck, Laurence H, Beck, David M, Bonegio, Ramon G.B, Lambeau, Gérard, Powell, David W, Cummins, Timothy D, Klein, Jon B, Salant, David J

“…In this study of patients with membranous nephropathy, serum samples from 70% of patients with idiopathic, but not secondary, membranous nephropathy were found…”
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An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy by Hoxha, Elion, Beck, Jr, Laurence H, Wiech, Thorsten, Tomas, Nicola M, Probst, Christian, Mindorf, Swantje, Meyer-Schwesinger, Catherine, Zahner, Gunther, Stahl, Phillip R, Schöpper, Ruth, Panzer, Ulf, Harendza, Sigrid, Helmchen, Udo, Salant, David J, Stahl, Rolf A K

“…Thrombospondin type 1 domain-containing 7A (THSD7A) is a target antigen identified in adult membranous nephropathy (MN) along with the major antigen…”
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The latest model has just arrived! A new experimental mouse model of PLA2R1-associated membranous nephropathy by Beck, Jr, Laurence H

“…Much akin to the explosion in number of known target antigens in membranous nephropathy, there has been a rapid expansion in the availability of animal models…”
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A Machine Learning Approach Enables Quantitative Measurement of Liver Histology and Disease Monitoring in NASH by Taylor‐Weiner, Amaro, Pokkalla, Harsha, Han, Ling, Jia, Catherine, Huss, Ryan, Chung, Chuhan, Elliott, Hunter, Glass, Benjamin, Pethia, Kishalve, Carrasco‐Zevallos, Oscar, Shukla, Chinmay, Khettry, Urmila, Najarian, Robert, Taliano, Ross, Subramanian, G. Mani, Myers, Robert P., Wapinski, Ilan, Khosla, Aditya, Resnick, Murray, Montalto, Michael C., Anstee, Quentin M., Wong, Vincent Wai‐Sun, Trauner, Michael, Lawitz, Eric J., Harrison, Stephen A., Okanoue, Takeshi, Romero‐Gomez, Manuel, Goodman, Zachary, Loomba, Rohit, Beck, Andrew H., Younossi, Zobair M.

“…Background and Aims Manual histological assessment is currently the accepted standard for diagnosing and monitoring disease progression in NASH, but is limited…”
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Membranous nephropathy: diagnosis, treatment, and monitoring in the post-PLA2R era by Safar-Boueri, Luisa, Piya, Albina, Beck, Laurence H., Ayalon, Rivka

“…Membranous nephropathy (MN) is an immune complex-mediated cause of the nephrotic syndrome that can occur in all age groups, from infants to the very elderly…”
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A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity by Grabiner, Brian C, Nardi, Valentina, Birsoy, Kıvanc, Possemato, Richard, Shen, Kuang, Sinha, Sumi, Jordan, Alexander, Beck, Andrew H, Sabatini, David M

“…Genes encoding components of the PI3K-AKT-mTOR signaling axis are frequently mutated in cancer, but few mutations have been characterized in MTOR, the gene…”
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Human-interpretable image features derived from densely mapped cancer pathology slides predict diverse molecular phenotypes by Diao, James A., Wang, Jason K., Chui, Wan Fung, Mountain, Victoria, Gullapally, Sai Chowdary, Srinivasan, Ramprakash, Mitchell, Richard N., Glass, Benjamin, Hoffman, Sara, Rao, Sudha K., Maheshwari, Chirag, Lahiri, Abhik, Prakash, Aaditya, McLoughlin, Ryan, Kerner, Jennifer K., Resnick, Murray B., Montalto, Michael C., Khosla, Aditya, Wapinski, Ilan N., Beck, Andrew H., Elliott, Hunter L., Taylor-Weiner, Amaro

“…Computational methods have made substantial progress in improving the accuracy and throughput of pathology workflows for diagnostic, prognostic, and genomic…”
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