Search Results - "Beck, Florian"

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment by Guo, Qiang, Lehmer, Carina, Martínez-Sánchez, Antonio, Rudack, Till, Beck, Florian, Hartmann, Hannelore, Pérez-Berlanga, Manuela, Frottin, Frédéric, Hipp, Mark S., Hartl, F. Ulrich, Edbauer, Dieter, Baumeister, Wolfgang, Fernández-Busnadiego, Rubén

“…Protein aggregation and dysfunction of the ubiquitin-proteasome system are hallmarks of many neurodegenerative diseases. Here, we address the elusive link…”
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High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from the Covid-19 severe acute respiratory syndrome coronavirus 2 by Zinzula, Luca, Basquin, Jerome, Bohn, Stefan, Beck, Florian, Klumpe, Sven, Pfeifer, Günter, Nagy, István, Bracher, Andreas, Hartl, F. Ulrich, Baumeister, Wolfgang

“…Unprecedented by number of casualties and socio-economic burden occurring worldwide, the coronavirus disease 2019 (Covid-19) pandemic caused by the severe…”
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Structure of the human 26S proteasome at a resolution of 3.9 Å by Schweitzer, Andreas, Aufderheide, Antje, Rudack, Till, Beck, Florian, Pfeifer, Günter, Plitzko, Jürgen M., Sakata, Eri, Schulten, Klaus, Förster, Friedrich, Baumeister, Wolfgang

“…Protein degradation in eukaryotic cells is performed by the Ubiquitin-Proteasome System (UPS). The 26S proteasome holocomplex consists of a core particle (CP)…”
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In situ structural analysis reveals membrane shape transitions during autophagosome formation by Bieber, Anna, Capitanio, Cristina, Erdmann, Philipp S, Fiedler, Fabian, Beck, Florian, Lee, Chia-Wei, Li, Delong, Hummer, Gerhard, Schulman, Brenda A, Baumeister, Wolfgang, Wilfling, Florian

“…Autophagosomes are unique organelles that form de novo as double-membrane vesicles engulfing cytosolic material for destruction. Their biogenesis involves…”
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Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach by Lasker, Keren, Förster, Friedrich, Bohn, Stefan, Walzthoeni, Thomas, Villa, Elizabeth, Unverdorben, Pia, Beck, Florian, Aebersold, Ruedi, Sali, Andrej, Baumeister, Wolfgang

“…The 26S proteasome is at the executive end of the ubiquitin-proteasome pathway for the controlled degradation of intracellular proteins. While the structure of…”
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The Architecture of Traveling Actin Waves Revealed by Cryo-Electron Tomography by Jasnin, Marion, Beck, Florian, Ecke, Mary, Fukuda, Yoshiyuki, Martinez-Sanchez, Antonio, Baumeister, Wolfgang, Gerisch, Günther

“…Actin waves are dynamic supramolecular structures involved in cell migration, cytokinesis, adhesion, and neurogenesis. Although wave-like propagation of actin…”
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In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli by Erdmann, Philipp S., Hou, Zhen, Klumpe, Sven, Khavnekar, Sagar, Beck, Florian, Wilfling, Florian, Plitzko, Jürgen M., Baumeister, Wolfgang

“…Ribosomes comprise a large (LSU) and a small subunit (SSU) which are synthesized independently in the nucleolus before being exported into the cytoplasm, where…”
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Structure of the 26S proteasome with ATP-γS bound provides insights into the mechanism of nucleotide-dependent substrate translocation by Śledź, Paweł, Unverdorben, Pia, Beck, Florian, Pfeifer, Günter, Schweitzer, Andreas, Förster, Friedrich, Baumeister, Wolfgang

“…The 26S proteasome is a 2.5-MDa, ATP-dependent multisubunit proteolytic complex that processively destroys proteins carrying a degradation signal. The…”
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Direct visualization of degradation microcompartments at the ER membrane by Albert, Sahradha, Wietrzynski, Wojciech, Lee, Chia-Wei, Schaffer, Miroslava, Beck, Florian, Schuller, Jan M., Salomé, Patrice A., Plitzko, Jürgen M., Baumeister, Wolfgang, Engel, Benjamin D.

“…To promote the biochemical reactions of life, cells can compartmentalize molecular interaction partners together within separated non–membrane-bound regions…”
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Near-atomic resolution structural model of the yeast 26S proteasome by Beck, Florian, Unverdorben, Pia, Bohn, Stefan, Schweitzer, Andreas, Pfeifer, Günter, Sakata, Eri, Nickell, Stephan, Plitzko, Jürgen M., Villa, Elizabeth, Baumeister, Wolfgang, Förster, Friedrich

“…The 26S proteasome operates at the executive end of the ubiquitinproteasome pathway. Here, we present a cryo-EM structure of the Saccharomyces cerevisiae 26S…”
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Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome by Unverdorben, Pia, Beck, Florian, Śledź, Pawel, Schweitzer, Andreas, Pfeifer, Günter, Plitzko, Jürgen M., Baumeister, Wolfgang, Förster, Friedrich

“…The 26S proteasome is a 2.5 MDa molecular machine that executes the degradation of substrates of the ubiquitin–proteasome pathway. The molecular architecture…”
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Volumetric macromolecule identification in cryo-electron tomograms using capsule networks by Hajarolasvadi, Noushin, Sunkara, Vikram, Khavnekar, Sagar, Beck, Florian, Brandt, Robert, Baum, Daniel

“…Abstract Background Despite recent advances in cellular cryo-electron tomography (CET), developing automated tools for macromolecule identification in…”
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Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating by Eisele, Markus R., Reed, Randi G., Rudack, Till, Schweitzer, Andreas, Beck, Florian, Nagy, Istvan, Pfeifer, Günter, Plitzko, Jürgen M., Baumeister, Wolfgang, Tomko, Robert J., Sakata, Eri

“…The proteasome is the central protease for intracellular protein breakdown. Coordinated binding and hydrolysis of ATP by the six proteasomal ATPase subunits…”
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Structural characterization of the interaction of Ubp6 with the 26S proteasome by Aufderheide, Antje, Florian Beck, Florian Stengel, Michaela Hartwig, Andreas Schweitzer, Günter Pfeifer, Alfred L. Goldberg, Eri Sakata, Wolfgang Baumeister, Friedrich Füörster

“…In eukaryotic cells the 26S proteasome is responsible for the regulated degradation of intracellular proteins. The function of this large macromolecular…”
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Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition by Beck, Florian, Geiger, Jörg, Gambaryan, Stepan, Solari, Fiorella A., Dell'Aica, Margherita, Loroch, Stefan, Mattheij, Nadine J., Mindukshev, Igor, Pötz, Oliver, Jurk, Kerstin, Burkhart, Julia M., Fufezan, Christian, Heemskerk, Johan W.M., Walter, Ulrich, Zahedi, René P., Sickmann, Albert

“…Adenosine diphosphate (ADP) enhances platelet activation by virtually any other stimulant to complete aggregation. It binds specifically to the…”
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An Empirical Investigation Into Deep and Shallow Rule Learning by Beck, Florian, Fürnkranz, Johannes

“…Inductive rule learning is arguably among the most traditional paradigms in machine learning. Although we have seen considerable progress over the years in…”
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Timeframe of socket cortication after tooth extraction: A retrospective radiographic study by Bertl, Kristina, Kukla, Edmund Benjamin, Albugami, Rajaa, Beck, Florian, Gahleitner, André, Stavropoulos, Andreas

“…Objectives To assess the timeframe between tooth extraction and radiographically detectable socket cortication in humans. Methods Two hundred and fifty…”
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Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution by Bohn, Stefan, Beck, Florian, Sakata, Eri, Walzthoeni, Thomas, Beck, Martin, Aebersold, Ruedi, Förster, Friedrich, Baumeister, Wolfgang, Nickell, Stephan

“…The structure of the 26S proteasome from Schizosaccharomyces pombe has been determined to a resolution of 9.1 Å by cryoelectron microscopy and single particle…”
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Correlative microscopy: Bridging the gap between fluorescence light microscopy and cryo-electron tomography by Sartori, Anna, Gatz, Rudolf, Beck, Florian, Rigort, Alexander, Baumeister, Wolfgang, Plitzko, Juergen M.

“…Cryo-electron tomography of frozen-hydrated biological samples offers a means of studying large and complex cellular structures in three-dimensions and with…”
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Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy by Sakata, Eri, Bohn, Stefan, Mihalache, Oana, Kiss, Petra, Beck, Florian, Nagy, Istvan, Nickell, Stephan, Tanaka, Keiji, Saeki, Yasushi, Förster, Friedrich, Baumeister, Wolfgang

“…Two canonical subunits of the 26S proteasome, Rpn10 and Rpn13, function as ubiquitin (Ub) receptors. The mutual arrangement of these subunits—and all other…”
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