Search Results - "Bechberger, John F"

Involvement of the Cytoplasmic C-Terminal Domain of Connexin43 in Neuronal Migration by Cina, Cima, Maass, Karen, Theis, Martin, Willecke, Klaus, Bechberger, John F, Naus, Christian C

“…During brain development, young neurons closely associate with radial glial while migrating from the ventricular zone (VZ) to the cortical plate (CP) of the…”
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Role of gap junction protein connexin43 in astrogliosis induced by brain injury by Theodoric, Nicolas, Bechberger, John F, Naus, Christian C, Sin, Wun-Chey

“…Astrogliosis is a process that involves morphological and biochemical changes associated with astrocyte activation in response to cell damage in the brain. The…”
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Tumor-suppressive effects of pannexin 1 in C6 glioma cells by LAI, Charles P. K, BECHBERGER, John F, THOMPSON, Roger J, MACVICAR, Brian A, BRUZZONE, Roberto, NAUS, Christian C

“…Mammalian gap junction proteins, connexins, have long been implicated in tumor suppression. Recently, a novel family of proteins named pannexins has been…”
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Expression of connexins in embryonic mouse neocortical development by Cina, Cima, Bechberger, John F., Ozog, Mark A., Naus, Christian C.G.

“…During embryonic development, young neurons migrate from the ventricular zone to the cortical plate of the cerebral cortex. Disturbances in this neuronal…”
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The Connexin43 C-Terminal Region Mediates Neuroprotection During Stroke by Kozoriz, Michael G, Bechberger, John F, Bechberger, Geralyn R, Suen, Michael W.H, Moreno, Alonso P, Maass, Karen, Willecke, Klaus, Naus, Christian C

“…Connexin43 plays an important role in neuroprotection in experimental stroke models; reducing the expression of this gap junction protein in astrocytes…”
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Mammary gland specific knockdown of the physiological surge in Cx26 during lactation retains normal mammary gland development and function by Stewart, Michael K G, Plante, Isabelle, Bechberger, John F, Naus, Christian C, Laird, Dale W

“…Connexin26 (Cx26) is the major Cx protein expressed in the human mammary gland and is up-regulated during pregnancy while remaining elevated throughout…”
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Dose-dependent differential upregulation of CCN1/Cyr61 and CCN3/NOV by the gap junction protein Connexin43 in glioma cells by Sin, Wun Chey, Bechberger, John F., Rushlow, Walter J., Naus, Christian C.

“…Gap junctions form channels that allow exchange of materials between cells and are composed of transmembrane protein subunits called connexins. While connexins…”
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Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke by Freitas-Andrade, Moises, Wang, Nan, Bechberger, John F, De Bock, Marijke, Lampe, Paul D, Leybaert, Luc, Naus, Christian C

“…Connexin43 (Cx43) function is influenced by kinases that phosphorylate specific serine sites located near its C-terminus. Stroke is a powerful inducer of…”
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Changes in Neuronal Migration in Neocortex of Connexin43 Null Mutant Mice by FUSHIKI, SHINJI, VELAZQUEZ, JOSE LUIS PEREZ, ZHANG, LIANG, BECHBERGER, JOHN F, CARLEN, PETER L, NAUS, CHRISTIAN C. G

“…To identify a neural phenotype in connexin43 null mutant mice, electrophysiological properties, intercellular communication and neuronal migration were studied…”
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Pannexin1 knockout and blockade reduces ischemic stroke injury in female, but not in male mice by Freitas-Andrade, Moises, Bechberger, John F, MacVicar, Brian A, Viau, Victor, Naus, Christian C

“…The membrane channel Pannexin 1 (Panx1) mediates apoptotic and inflammatory signaling cascades in injured neurons, responses previously shown to be sexually…”
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Podoplanin: A Marker for Reactive Gliosis in Gliomas and Brain Injury by Kolar, Kushal, Freitas-Andrade, Moises, Bechberger, John F, Krishnan, Harini, Goldberg, Gary S, Naus, Christian C, Sin, Wun Chey

“…ABSTRACTReactive astrogliosis is associated with many pathologic processes in the central nervous system, including gliomas. The glycoprotein podoplanin (PDPN)…”
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Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and Src activity by ALEXANDER, David B, ICHIKAWA, Hitoshi, BECHBERGER, John F, VALIUNAS, Virginijus, OHKI, Misao, NAUS, Christian C. G, KUNIMOTO, Takehiko, TSUDA, Hiroyuki, MILLER, W. Todd, GOLDBERG, Gary S

“…The growth of many types of cancer cells can be controlled by surrounding normal cells. However, mechanisms underlying this phenomenon have not been defined…”
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Pannexin 2 protein expression is not restricted to the CNS by Le Vasseur, Maxence, Lelowski, Jonathan, Bechberger, John F, Sin, Wun-Chey, Naus, Christian C

“…Pannexins (Panx) are proteins homologous to the invertebrate gap junction proteins called innexins (Inx) and are traditionally described as transmembrane…”
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Comorbid Aβ toxicity and stroke: hippocampal atrophy, pathology, and cognitive deficit by Amtul, Zareen, Nikolova, Simona, Gao, Lulu, Keeley, Robin J, Bechberger, John F, Fisher, Alicia L, Bartha, Robert, Munoz, David G, McDonald, Robert J, Naus, Christian C, Wojtowicz, J. Martin, Hachinski, Vladimir, Cechetto, David F

“…Abstract Numerous clinical and epidemiological reports indicate that patients with history of vascular illness such as stroke are more likely to develop…”
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Matrix‐assisted laser desorption/ionization imaging mass spectrometry of intraperitoneally injected danegaptide (ZP1609) for treatment of stroke‐reperfusion injury in mice by Wang, Jasmine S.H., Freitas‐Andrade, Moises, Bechberger, John F., Naus, Christian C., Yeung, Ken K.‐C., Whitehead, Shawn N.

“…Rationale This work focuses on direct matrix‐assisted laser desorption/ionization imaging mass spectrometry (MALDI‐IMS) detection of intraperitoneally…”
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The C-terminal domain of connexin43 modulates cartilage structure via chondrocyte phenotypic changes by Gago-Fuentes, Raquel, Bechberger, John F, Varela-Eirin, Marta, Varela-Vazquez, Adrian, Acea, Benigno, Fonseca, Eduardo, Naus, Christian C, Mayan, Maria D

“…Chondrocytes in cartilage and bone cells population express connexin43 (Cx43) and gap junction intercellular communication (GJIC) is essential to synchronize…”
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Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer by Stewart, Michael K G, Bechberger, John F, Welch, Ian, Naus, Christian C, Laird, Dale W

“…Down-regulation of the gap junction protein connexin26 (Cx26) is an early event following breast cancer onset and has led to Cx26 being classically described…”
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Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia by Kozoriz, Michael G., Lai, Simon, Vega, José L., Sáez, Juan C., Sin, Wun Chey, Bechberger, John F., Naus, Christian C.

“…Oculodentodigital dysplasia (ODDD) is a rare autosomal dominant disease that results in visible developmental anomalies of the limbs, face, eyes and teeth…”
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CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression by Fu, Christine T, Bechberger, John F, Ozog, Mark A, Perbal, Bernard, Naus, Christian C

“…Many tumor cells exhibit aberrant gap junctional intercellular communication, which can be restored by transfection with connexin genes. We have previously…”
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Genistein and quercetin increase connexin43 and suppress growth of breast cancer cells by Conklin, Chris M.J., Bechberger, John F., MacFabe, Derrick, Guthrie, Najla, Kurowska, Elzbieta M., Naus, Christian C.

“…Connexin proteins form gap junctions, which permit direct exchange of cytoplasmic contents between neighboring cells. Evidence indicates that gap junctional…”
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