Search Results - "Bechara, Chérine"

Cell‐penetrating peptides: 20 years later, where do we stand? by Bechara, Chérine, Sagan, Sandrine

“…Twenty years ago, the discovery of peptides able to cross cellular membranes launched a novel field in molecular delivery based on these non‐invasive vectors,…”
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Different Modes of Lipid Binding to Membrane Proteins Probed by Mass Spectrometry by Bechara, Chérine, Robinson, Carol V

“…The realization that the lipid environment is crucial for maintaining the structure and function of membrane proteins prompts new methods to understand lipid…”
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A subset of annular lipids is linked to the flippase activity of an ABC transporter by Bechara, Chérine, Nöll, Anne, Morgner, Nina, Degiacomi, Matteo T., Tampé, Robert, Robinson, Carol V.

“…Lipids are critical components of membranes that could affect the properties of membrane proteins, yet the precise compositions of lipids surrounding…”
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Structural insights into adiponectin receptors suggest ceramidase activity by Vasiliauskaité-Brooks, Ieva, Sounier, Remy, Rochaix, Pascal, Bellot, Gaëtan, Fortier, Mathieu, Hoh, François, De Colibus, Luigi, Bechara, Chérine, Saied, Essa M., Arenz, Christoph, Leyrat, Cédric, Granier, Sébastien

“…Structures of the adiponectin receptors ADIPOR1 and ADIPOR2 combined with molecular dynamics simulations and enzymatic assays suggest that both receptors have…”
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Tryptophan within basic peptide sequences triggers glycosaminoglycan‐dependent endocytosis by Bechara, Chérine, Pallerla, Manjula, Zaltsman, Yefim, Burlina, Fabienne, Alves, Isabel D., Lequin, Olivier, Sagan, Sandrine

“…Deciphering the structural requirements and mechanisms for internalization of cell‐penetrating peptides (CPPs) is required to improve their delivery…”
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Massive glycosaminoglycan-dependent entry of Trp-containing cell-penetrating peptides induced by exogenous sphingomyelinase or cholesterol depletion by Bechara, Chérine, Pallerla, Manjula, Burlina, Fabienne, Illien, Françoise, Cribier, Sophie, Sagan, Sandrine

“…Among non-invasive cell delivery strategies, cell-penetrating peptide (CPP) vectors represent interesting new tools. To get fundamental knowledge about the…”
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The TOPOVIBL meiotic DSB formation protein: new insights from its biochemical and structural characterization by Diagouraga, Boubou, Tambones, Izabella, Carivenc, Coralie, Bechara, Chérine, Nadal, Marc, de Massy, Bernard, le Maire, Albane, Robert, Thomas

“…Abstract The TOPOVIL complex catalyzes the formation of DNA double strand breaks (DSB) that initiate meiotic homologous recombination, an essential step for…”
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Small AntiMicrobial Peptide With in Vivo Activity Against Sepsis by Boullet, Héloise, Bentot, Fayçal, Hequet, Arnaud, Ganem-Elbaz, Carine, Bechara, Chérine, Pacreau, Emeline, Launay, Pierre, Sagan, Sandrine, Jolivalt, Claude, Lacombe, Claire, Moumné, Roba, Karoyan, Philippe

“…Antimicrobial peptides (AMPs) are considered as potential therapeutic sources of future antibiotics because of their broad-spectrum activities and alternative…”
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MALDI-TOF Mass Spectrometry Analysis of Amphipol-Trapped Membrane Proteins by Bechara, Chérine, Bolbach, Gérard, Bazzaco, Paola, Sharma, K. Shivaji, Durand, Grégory, Popot, Jean-Luc, Zito, Francesca, Sagan, Sandrine

“…Amphipols (APols) are amphipathic polymers with the ability to substitute detergents to keep membrane proteins (MPs) soluble and functional in aqueous…”
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Toxoplasma gondii chromosomal passenger complex is essential for the organization of a functional mitotic spindle: a prerequisite for productive endodyogeny by Berry, Laurence, Chen, Chun-Ti, Francia, Maria E., Guerin, Amandine, Graindorge, Arnault, Saliou, Jean-Michel, Grandmougin, Maurane, Wein, Sharon, Bechara, Chérine, Morlon-Guyot, Juliette, Bordat, Yann, Gubbels, Marc-Jan, Lebrun, Maryse, Dubremetz, Jean-François, Daher, Wassim

“…The phylum Apicomplexa encompasses deadly pathogens such as malaria and Cryptosporidium . Apicomplexa cell division is mechanistically divergent from that of…”
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Molecular partners for interaction and cell internalization of cell-penetrating peptides: how identical are they? by Walrant, Astrid, Bechara, Chérine, Alves, Isabel D, Sagan, Sandrine

“…Cell-penetrating peptides are short basic peptide sequences that might display amphipathic properties. These positively charged peptides internalize into all…”
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Small Molecule Inhibitors of Disulfide Bond Formation by the Bacterial DsbA–DsbB Dual Enzyme System by Halili, Maria A, Bachu, Prabhakar, Lindahl, Fredrik, Bechara, Chérine, Mohanty, Biswaranjan, Reid, Robert C, Scanlon, Martin J, Robinson, Carol V, Fairlie, David P, Martin, Jennifer L

“…The DsbA:DsbB redox machinery catalyzes disulfide bond formation in secreted proteins and is required for bacterial virulence factor assembly. Both enzymes…”
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Self-assembling mini cell-penetrating peptides enter by both direct translocation and glycosaminoglycan-dependent endocytosis by Bode, Saskia A, Thévenin, Marion, Bechara, Chérine, Sagan, Sandrine, Bregant, Sarah, Lavielle, Solange, Chassaing, Gérard, Burlina, Fabienne

“…A small library of cell-penetrating peptides (CPPs) containing a minimized cationic domain and a lipophilic domain of different size was studied. CPPs that…”
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Homeoproteins and homeoprotein-derived peptides: going in and out by Sagan, Sandrine, Burlina, Fabienne, Alves, Isabel D, Bechara, Chérine, Dupont, Edmond, Joliot, Alain

“…Since the initial evidence that antennapedia homeobox can cross cell membranes and internalize into cells, numerous peptides with similar translocation…”
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Flexible Stoichiometry and Asymmetry of the PIDDosome Core Complex by Heteronuclear NMR Spectroscopy and Mass Spectrometry by Nematollahi, Lily A., Garza-Garcia, Acely, Bechara, Chérine, Esposito, Diego, Morgner, Nina, Robinson, Carol V., Driscoll, Paul C.

“…Homotypic death domain (DD)–DD interactions are important in the assembly of oligomeric signaling complexes such as the PIDDosome that acts as a platform for…”
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Is there anybody in there? On the mechanisms of wall crossing of cell penetrating peptides by Alves, Isabel D, Walrant, Astrid, Bechara, Chérine, Sagan, Sandrine

“…Cell penetrating peptides (CPPs) belong to the large family of membrane active peptides that comprises antimicrobial and viral fusion peptides with whom they…”
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Study of CPP Mechanisms by Mass Spectrometry by Sagan, Sandrine, Bechara, Chérine, Burlina, Fabienne

“…Studying the mechanisms of entry of cell-penetrating peptides (CPPs) requires reliable methods to measure their cellular uptake efficiency, monitor their…”
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Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex by Gruszczyk, Jakub, Grandvuillemin, Loïc, Lai-Kee-Him, Josephine, Paloni, Matteo, Savva, Christos G., Germain, Pierre, Grimaldi, Marina, Boulahtouf, Abdelhay, Kwong, Hok-Sau, Bous, Julien, Ancelin, Aurélie, Bechara, Cherine, Barducci, Alessandro, Balaguer, Patrick, Bourguet, William

“…The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates a broad spectrum of (patho)physiological processes in response to…”
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High-resolution mass spectrometry of small molecules bound to membrane proteins by Gault, Joseph, Donlan, Joseph A C, Liko, Idlir, Hopper, Jonathan T S, Gupta, Kallol, Housden, Nicholas G, Struwe, Weston B, Marty, Michael T, Mize, Todd, Bechara, Cherine, Zhu, Ya, Wu, Beili, Kleanthous, Colin, Belov, Mikhail, Damoc, Eugen, Makarov, Alexander, Robinson, Carol V

“…A high-resolution, Orbitrap-based, native mass spectrometry approach allows the direct characterization of lipid, peptide and drug binding to intact membrane…”
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Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins by Lambey, Paul, Otun, Omolade, Cong, Xiaojing, Hoh, François, Brunel, Luc, Verdié, Pascal, Grison, Claire M, Peysson, Fanny, Jeannot, Sylvain, Durroux, Thierry, Bechara, Cherine, Granier, Sébastien, Leyrat, Cédric

“…(SA) leukocidin ED (LukED) belongs to a family of bicomponent pore forming toxins that play important roles in SA immune evasion and nutrient acquisition…”
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