Effect of solubilizers on the androgenic activity of Basella alba L. (Basellaceae) in adult male rats
Article info Article History : Received: 11 October 2015 Revised: 22 December 2016 Accepted: 23 February 2017 ePublished: 13 April 2017 Keywords: * Basella alba * Solubilizer * Androgenic activity * Male rat Abstract Purpose: Solubilizers play an important role in dissolution of pharmacological ingr...
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| Published in: | Advanced pharmaceutical bulletin Vol. 7; no. 1; pp. 103 - 108 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Tabriz
Tabriz University of Medical Sciences
01-04-2017
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Article info Article History : Received: 11 October 2015 Revised: 22 December 2016 Accepted: 23 February 2017 ePublished: 13 April 2017 Keywords: * Basella alba * Solubilizer * Androgenic activity * Male rat Abstract Purpose: Solubilizers play an important role in dissolution of pharmacological ingredients and should properly dissolve the active principle(s) while preserving its activities. Introduction Basella alba is a green leafy vegetable used as medicinal plant in folk medicine for treatment of male reproductive dysfunctions in West Region of Cameroon.1 Previous scientific studies showed that the active principles of B. alba were concentrated in the methanol fraction.2,3 Indeed, the stimulatory effect of the methanol extract of B. alba (MEBa) on testosterone release has been demonstrated in Leydig cells and male rats.2,4,5 The MEBa increased fecundity of rats exposed to flutamide in utero and alleviated maneb-induced deleterious effects on male reproductive function.6,7 Its antioxidant activity has been demonstrated using testicular homogenates. B. alba has also been shown to exhibit anti-inflammatory, hypocholesterolemic and antiatherosclerotic potetials.8-10 This plant is consumed as vegetable in other parts of the world including India, and phytochemical studies have revealed that it contains substantial amounts of antioxidant compounds such as ascorbic acid, carotenoids and phenolics.11-13 Consumption of the plant as food suggests that it may be safe, and the reported androgenic and antioxidant effects favor its use for treatment of male reproductive disorders attributed to androgen deficiency. Solubilizers are used to modify the polarity of water to allow an increase in the solubility of a nonpolar... |
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| ISSN: | 2228-5881 2251-7308 |
| DOI: | 10.15171/apb.2017.013 |