Search Results - "Bebernitz, Gregory"

Investigation of Functionally Liver Selective Glucokinase Activators for the Treatment of Type 2 Diabetes by Bebernitz, Gregory R, Beaulieu, Valerie, Dale, Bethany A, Deacon, Richard, Duttaroy, Alokesh, Gao, Jiaping, Grondine, Melissa S, Gupta, Ramesh C, Kakmak, Mesut, Kavana, Michael, Kirman, Louise C, Liang, Jinsheng, Maniara, Wieslawa M, Munshi, Siralee, Nadkarni, Sunil S, Schuster, Herbert F, Stams, Travis, St. Denny, Irene, Taslimi, Paul M, Vash, Brian, Caplan, Shari L

“…Type 2 diabetes is a polygenic disease which afflicts nearly 200 million people worldwide and is expected to increase to near epidemic levels over the next…”
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Avoidance of the Ames test liability for aryl–amines via computation by McCarren, Patrick, Bebernitz, Gregory R., Gedeck, Peter, Glowienke, Susanne, Grondine, Melissa S., Kirman, Louise C., Klickstein, Jacob, Schuster, Herbert F., Whitehead, Lewis

“…Aryl–amines are commonly used synthons in modern drug discovery, however a minority of these chemical templates have the potential to cause toxicity through…”
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The Effect of 1,3-Diaryl-[1H]-pyrazole-4-acetamides on Glucose Utilization in ob/ob Mice by Bebernitz, Gregory R, Argentieri, Greg, Battle, Beverly, Brennan, Christine, Balkan, Bork, Burkey, Bryan F, Eckhardt, Michele, Gao, Jiaping, Kapa, Prasad, Strohschein, Robert J, Schuster, Herbert F, Wilson, Mary, Xu, David D

“…This article provides evidence of a new class of compounds, 1,3-diaryl-[1H]-pyrazole-4-acetamides, initially identified from their ability to increase glucose…”
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The impact of fatty acid oxidation on energy utilization: targets and therapy by Bebernitz, Gregory R, Schuster, Herbert F

“…Utilization of fat as a long-term energy storage vehicle is crucial for the maintenance of cellular metabolism and is under intricate and many times redundant…”
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Anilides of (R)-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase by Bebernitz, Gregory R, Aicher, Thomas D, Stanton, James L, Gao, Jiaping, Shetty, Suraj S, Knorr, Douglas C, Strohschein, Robert J, Tan, Jennifer, Brand, Leonard J, Liu, Charles, Wang, Wei H, Vinluan, Christine C, Kaplan, Emma L, Dragland, Carol J, DelGrande, Dominick, Islam, Amin, Lozito, Robert J, Liu, Xilin, Maniara, Wieslawa M, Mann, William R

“…The optimization of a series of anilide derivatives of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase…”
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Discovery of a brain-sparing GIRK1/4 inhibitor for pharmacological cardioversion of atrial fibrillation by Peukert, Stefan, Gulgeze Efthymiou, Hatice Belgin, Mo, Ruowei, Peng, Yunshan, Ma, Fupeng, Barbe, Guillaume, Bebernitz, Gregory, Fridrich, Cary, Buono, Chiara, Williams, Eric T., Daniels, Thomas, Li, Lisha, Zhang, Xia, Adachi, Yuichiro, Abe, Mie, Taggart, Andrew K.P.

“…[Display omitted] Atrial fibrillation (AF) is the most common cardiac arrhythmia, and a significant risk factor for ischemic stroke and heart failure. Marketed…”
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Reduction in Glucose Levels in STZ Diabetic Rats by 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid:  A Prodrug Approach for Targeting the Liver by Bebernitz, Gregory R, Dain, Jeremy G, Deems, Rhonda O, Otero, Dario A, Simpson, W. Ronald, Strohschein, Robert J

“…The overproduction of glucose by the liver in NIDDM patients markedly contributes to their fasting hyperglycemia and is a direct consequence of the increased…”
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Reduction in Glucose Levels in STZ Diabetic Rats by 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid:  A Prodrug Approach for Targeting the Liver by Bebernitz, Gregory R, Dain, Jeremy G, Deems, Rhonda O, Otero, Dario A, Simpson, W. Ronald, Strohschein, Robert J

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Hypoglycemic Prodrugs of 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid by Aicher, Thomas D, Bebernitz, Gregory R, Bell, Philip A, Brand, Leonard J, Dain, Jeremy G, Deems, Rhonda, Fillers, William S, Foley, James E, Knorr, Douglas C, Nadelson, Jeffrey, Otero, Dario A, Simpson, Ronald, Strohschein, Robert J, Young, Douglas A

“…SAH 51-641 (1) is a potent hypoglycemic agent, which acts by inhibiting hepatic gluconeogenesis. It is a prodrug of 4-(2,2-dimethyl-1-oxopropyl)benzoic acid…”
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Hepatic glycogen cycling contributes to glucose lowering effects of the glucokinase activator LCZ960 by Laurent, Didier, Yerby, Brittany, Zhang, Bailin, Chen, Xiao-Hui, Gounarides, John, Zhang, JieL, Gao, Jiaping, Bebernitz, Gregory, Duttaroy, Alokesh

“…Glucokinase (GK) acts as a glucose sensor by facilitating glucose phosphorylation into glucose-6-phosphate (G6P) in the liver and pancreas, the two key target…”
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BACE1/2 INHIBITION DOES NOT REGULATE PANCREATIC BETA CELL FUNCTION AND MASS IN MICE by O'Donnell, Peter, Neumann, Ulf, Pietropaolo, Michael, Fleming, Michael, Chen, Xinyu, Wang, Xiurong, Nettleton, David, Bebernitz, Gregory, Kunjathoor, Vidya

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P2‐059: BACE1/2 INHIBITION DOES NOT REGULATE PANCREATIC BETA CELL FUNCTION AND MASS IN MICE by O'Donnell, Peter, Neumann, Ulf, Pietropaolo, Michael, Fleming, Michael, Chen, Xinyu, Wang, Xiurong, Nettleton, David, Bebernitz, Gregory, Kunjathoor, Vidya

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(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase by Aicher, Thomas D, Anderson, Robert C, Bebernitz, Gregory R, Coppola, Gary M, Jewell, Charles F, Knorr, Douglas C, Liu, Charles, Sperbeck, Donald M, Brand, Leonard J, Strohschein, Robert J, Gao, Jiaping, Vinluan, Christine C, Shetty, Suraj S, Dragland, Carol, Kaplan, Emma L, DelGrande, Dominick, Islam, Amin, Liu, Xilin, Lozito, Robert J, Maniara, Wieslawa M, Walter, R. Erik, Mann, William R

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( R )-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase by Aicher, Thomas D., Anderson, Robert C., Bebernitz, Gregory R., Coppola, Gary M., Jewell, Charles F., Knorr, Douglas C., Liu, Charles, Sperbeck, Donald M., Brand, Leonard J., Strohschein, Robert J., Gao, Jiaping, Vinluan, Christine C., Shetty, Suraj S., Dragland, Carol, Kaplan, Emma L., DelGrande, Dominick, Islam, Amin, Liu, Xilin, Lozito, Robert J., Maniara, Wieslawa M., Walter, R. Erik, Mann, William R.

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