Search Results - "Bebenek, Anna"

Fidelity consequences of the impaired interaction between DNA polymerase epsilon and the GINS complex by Garbacz, Marta, Araki, Hiroyuki, Flis, Krzysztof, Bebenek, Anna, Zawada, Anna E., Jonczyk, Piotr, Makiela-Dzbenska, Karolina, Fijalkowska, Iwona J.

“…•The dpb2-100 allele encodes the mutant form of Dpb2p, the noncatalytic subunit of Pol ɛ.•It does not change the biochemical properties of DNA Pol ɛ…”
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Fidelity of DNA replication—a matter of proofreading by Bębenek, Anna, Ziuzia-Graczyk, Izabela

“…DNA that is transmitted to daughter cells must be accurately duplicated to maintain genetic integrity and to promote genetic continuity. A major function of…”
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A remote palm domain residue of RB69 DNA polymerase is critical for enzyme activity and influences the conformation of the active site by Jacewicz, Agata, Trzemecka, Anna, Guja, Kip E, Plochocka, Danuta, Yakubovskaya, Elena, Bebenek, Anna, Garcia-Diaz, Miguel

“…Non-conserved amino acids that are far removed from the active site can sometimes have an unexpected effect on enzyme catalysis. We have investigated the…”
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Clusters of Mutations from Transient Hypermutability by Drake, John W., Bebenek, Anna, Kissling, Grace E., Peddada, Shyamal, Hanawalt, Philip C.

“…Collections of mutants usually contain more mutants bearing multiple mutations than expected from the mutant frequency and a random distribution of mutations…”
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Interacting Fidelity Defects in the Replicative DNA Polymerase of Bacteriophage RB69 by Bebenek, Anna, Dressman, Holly Kloos, Carver, Geraldine T., Ng, San-san, Petrov, Vasiliy, Yang, Guangwei, Konigsberg, William H., Karam, Jim D., Drake, John W.

“…The DNA polymerases (gp43s) of the related bacteriophages T4 and RB69 are B family (polymerase α class) enzymes that determine the fidelity of phage DNA…”
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Varying thermodynamic conditions as a new way to tune the molecular order in glassy itraconazole by Heczko, Dawid, Kamińska, Ewa, Tarnacka, Magdalena, Jurkiewicz, Karolina, Dulski, Mateusz, Bębenek, Anna, Garbacz, Grzegorz, Kamiński, Kamil, Paluch, Marian

“…In this paper, comprehensive calorimetric, structural, inter- and intramolecular dynamics measurements with the use of Differential Scanning Calorimetry (DSC),…”
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Dissecting the Fidelity of Bacteriophage RB69 DNA Polymerase: Site-Specific Modulation of Fidelity by Polymerase Accessory Proteins by Bebenek, Anna, Carver, Geraldine T, Dressman, Holly Kloos, Kadyrov, Farid A, Haseman, Joseph K, Petrov, Vasiliy, Konigsberg, William H, Karam, Jim D, Drake, John W

“…Bacteriophage RB69 encodes a replicative B-family DNA polymerase (RB69 gp43) with an associated proofreading 3' exonuclease. Crystal structures have been…”
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DNA replication fidelity by Bebenek, Anna

“…DNA replication fidelity plays fundamental role in faithful transmission of genetic material during cell division and during transfer of genetic material from…”
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Reversal of a Mutator Activity by a Nearby Fidelity-Neutral Substitution in the RB69 DNA Polymerase Binding Pocket by Trzemecka, Anna, Jacewicz, Agata, Carver, Geraldine T., Drake, John W., Bebenek, Anna

“…Phage RB69 B-family DNA polymerase is responsible for the overall high fidelity of RB69 DNA synthesis. Fidelity is compromised when conserved Tyr567, one of…”
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Different Behaviors In Vivo of Mutations in the β Hairpin Loop of the DNA Polymerases of the Closely Related Phages T4 and RB69 by Trzemecka, Anna, Płochocka, Danuta, Bebenek, Anna

“…The T4 and RB69 DNA replicative polymerases are members of the B family and are highly similar. Both replicate DNA with high fidelity and employ the same…”
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Prokaryotic primases - structure and function by Ziuzia-Graczyk, Izabela, Bębenek, Anna

“…Primases are responsible for the synthesis of a short oligo RNA, which serves as primer for DNA polymerase. Primases play an essential role in the initiation…”
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A Remote Palm Domain Residue of RB69 DNA Polymerase Is Critical for Enzyme Activity and Influences the Conformation of the Active Site: e76700 by Jacewicz, Agata, Trzemecka, Anna, Guja, Kip E, Plochocka, Danuta, Yakubovskaya, Elena, Bebenek, Anna, Garcia-Diaz, Miguel

“…Non-conserved amino acids that are far removed from the active site can sometimes have an unexpected effect on enzyme catalysis. We have investigated the…”
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The L561A Substitution in the Nascent Base-Pair Binding Pocket of RB69 DNA Polymerase Reduces Base Discrimination by Zhang, Hong, Rhee, Chanu, Bebenek, Anna, Drake, John W, Wang, Jimin, Konigsberg, William

“…Several variants of RB69 DNA polymerase (RB69 pol) with single-site replacements in the nascent base-pair binding pocket are less discriminating with respect…”
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The Roles of Tyr391 and Tyr619 in RB69 DNA Polymerase Replication Fidelity by Jacewicz, Agata, Makiela, Karolina, Kierzek, Andrzej, Drake, John W., Bebenek, Anna

“…In the family-B DNA polymerase of bacteriophage RB69, the conserved aromatic palm-subdomain residues Tyr391 and Tyr619 interact with the last primer–template…”
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Processivity Clamp gp45 and ssDNA-Binding-Protein gp32 Modulate the Fidelity of Bacteriophage RB69 DNA Polymerase in a Sequence-Specific Manner, Sometimes Enhancing and Sometimes Compromising Accuracy by Bebenek, Anna, Carver, Geraldine T, Kadyrov, Farid A, Kissling, Grace E, Drake, John W

“…Numerous studies of the impact of accessory proteins upon the fidelity of DNA synthesis have provided a complex and sometimes discordant picture. We previously…”
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Processivity Clamp gp45 and ssDNA-Binding-Protein gp32 Modulate the Fidelity of Bacteriophage RB69 DNA Polymerase in a Sequence-Specific Manner, Sometimes Enhancing and Sometimes Compromising Accuracy by Bebenek, Anna, Carver, Geraldine T, Kadyrov, Farid A, Kissling, Grace E, Drake, John W

“…Numerous studies of the impact of accessory proteins upon the fidelity of DNA synthesis have provided a complex and sometimes discordant picture. We previously…”
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Bacteriophage T4 rnh (RNase H) Null Mutations: Effects on Spontaneous Mutation and Epistatic Interaction withrII Mutations by Anna Bebenek, Leslie A. Smith, John W. Drake

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The isfA mutation specifically inhibits the SOS-dependent mutagenic pathway and does not selectively affect any particular base substitution by Felczak, Magdalena, Bebenek, Anna, Pietrzykowska, Irena

“…We have previously described a new mutation in Escherichia coli, isfA, which causes inhibition of SOS mutagenesis (UV-induced in rec+ and spontaneous in…”
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Bacteriophage T4 rnh (RNase H) null mutations: effects on spontaneous mutation and epistatic interaction with rII mutations by Bebenek, A, Smith, L A, Drake, J W

“…The bacteriophage T4 rnh gene encodes T4 RNase H, a relative of a family of flap endonucleases. T4 rnh null mutations reduce burst sizes, increase sensitivity…”
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A new mutation in Escherichia coli K12, isfA, which is responsible for inhibition of SOS functions by Bebenek, A, Pietrzykowska, I

“…A new mutation in Escherichia coli K12, isfA, is described, which causes inhibition of SOS functions. The mutation, discovered in a delta polA+ mutant, is…”
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