Search Results - "Bebel, Aleksandra"

A novel DNA primase-helicase pair encoded by SCCmec elements by Bebel, Aleksandra, Walsh, Melissa A, Mir-Sanchis, Ignacio, Rice, Phoebe A

“…Mobile genetic elements (MGEs) are a rich source of new enzymes, and conversely, understanding the activities of MGE-encoded proteins can elucidate MGE…”
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Mechanistic and Structural Insights on Difluoromethyl-1,3,4-oxadiazole Inhibitors of HDAC6 by Cellupica, Edoardo, Gaiassi, Aureliano, Rocchio, Ilaria, Rovelli, Grazia, Pomarico, Roberta, Sandrone, Giovanni, Caprini, Gianluca, Cordella, Paola, Cukier, Cyprian, Fossati, Gianluca, Marchini, Mattia, Bebel, Aleksandra, Airoldi, Cristina, Palmioli, Alessandro, Stevenazzi, Andrea, Steinkühler, Christian, Vergani, Barbara

“…Histone deacetylase 6 (HDAC6) is increasingly recognized for its potential in targeted disease therapy. This study delves into the mechanistic and structural…”
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Structural snapshots of Xer recombination reveal activation by synaptic complex remodeling and DNA bending by Bebel, Aleksandra, Karaca, Ezgi, Kumar, Banushree, Stark, W Marshall, Barabas, Orsolya

“…Bacterial Xer site-specific recombinases play an essential genome maintenance role by unlinking chromosome multimers, but their mechanism of action has…”
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Transposase-DNA Complex Structures Reveal Mechanisms for Conjugative Transposition of Antibiotic Resistance by Rubio-Cosials, Anna, Schulz, Eike C., Lambertsen, Lotte, Smyshlyaev, Georgy, Rojas-Cordova, Carlos, Forslund, Kristoffer, Karaca, Ezgi, Bebel, Aleksandra, Bork, Peer, Barabas, Orsolya

“…Conjugative transposition drives the emergence of multidrug resistance in diverse bacterial pathogens, yet the mechanisms are poorly characterized. The Tn1549…”
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Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals by Kuusisto, Kirsi M, Bebel, Aleksandra, Vihinen, Mauno, Schleutker, Johanna, Sallinen, Satu-Leena

“…Two major high-penetrance breast cancer genes, BRCA1 and BRCA2, are responsible for approximately 20% of hereditary breast cancer (HBC) cases in Finland…”
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Targeting IS608 transposon integration to highly specific sequences by structure-based transposon engineering by Morero, Natalia Rosalía, Zuliani, Cecilia, Kumar, Banushree, Bebel, Aleksandra, Okamoto, Sachi, Guynet, Catherine, Hickman, Alison Burgess, Chandler, Michael, Dyda, Fred, Barabas, Orsolya

“…Abstract Transposable elements are efficient DNA carriers and thus important tools for transgenesis and insertional mutagenesis. However, their poor target…”
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A novel DNA primase-helicase pair encoded by SCC mec elements by Bebel, Aleksandra, Walsh, Melissa A, Mir-Sanchis, Ignacio, Rice, Phoebe A

“…Mobile genetic elements (MGEs) are a rich source of new enzymes, and conversely, understanding the activities of MGE-encoded proteins can elucidate MGE…”
Get full text

Mechanistic insights into xer recombination and conjugative transposition in helicobacter pylori by Bebel, Aleksandra

“…Site-specific recombinases of the Xer family are essential in most bacteria with circular chromosomes for the resolution of chromosome dimers arising after…”
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