Search Results - "Beazely, Michael A."

Differential Effects of Endocannabinoids on Amyloid-Beta Aggregation and Toxicity by Khavandi, Marzie, Rao, Praveen P N, Beazely, Michael A

“…The regulation and metabolism of the endocannabinoid system has received extensive attention for their potential neuroprotective effect in neurodegenerative…”
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Activation of Pannexin-1 Hemichannels Augments Aberrant Bursting in the Hippocampus by Thompson, Roger J, Jackson, Michael F, Olah, Michelle E, Rungta, Ravi L, Hines, Dustin J, Beazely, Michael A, MacDonald, John F, MacVicar, Brian A

“…Pannexin-1 (Px1) is expressed at postsynaptic sites in pyramidal neurons, suggesting that these hemichannels contribute to dendritic signals associated with…”
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What Is Known about Community Pharmacy-Based Take-Home Naloxone Programs and Program Interventions? A Scoping Review by Cid, Ashley, Daskalakis, George, Grindrod, Kelly, Beazely, Michael A

“…A variety of new sources describing community pharmacy-based take-home naloxone (THN) programs have emerged recently in the literature. There is a need to…”
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Adapting the Opening Minds Stigma Scale for Healthcare Providers to Measure Opioid-Related Stigma by Cid, Ashley, Patten, Alec, Beazely, Michael A, Grindrod, Kelly

“…The opioid crisis in Canada continues to cause a devastating number of deaths. Community-based naloxone programs have been identified as one of the solutions…”
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Association Between Opioid-Related Mortality and History of Surgical Procedure: A Population-Based Case-Control Study by Alsabbagh, Mhd Wasem, Beazely, Michael A, Spasik, Leona

“…This study examined whether there is an association between opioid-related mortality and surgical procedures. A case-control study design using deceased…”
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Preclinical development and ocular biodistribution of gemini-DNA nanoparticles after intravitreal and topical administration: Towards non-invasive glaucoma gene therapy by Alqawlaq, Samih, MSc, Sivak, Jeremy M., PhD, Huzil, J. Torin, PhD, Ivanova, Marina V., MSc, Flanagan, John G., PhD, Beazely, Michael A., PhD, Foldvari, Marianna, PhD

“…Abstract Gene therapy could offer improvement in the treatment of glaucoma compared to the current standard of lowering intraocular pressure. We have developed…”
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Search for lithium isotope effects in neuronal HT22 cells by Livingstone, James D., Gingras, Michel J.P., Leonenko, Zoya, Beazely, Michael A.

“…Lithium has been used as a treatment for bipolar disorder for over half a century, but there has thus far been no clinical differentiation made between the two…”
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Investigating Community Pharmacy Take Home Naloxone Dispensing during COVID-19: The Impact of One Public Health Crisis on Another by Daskalakis, George, Cid, Ashley, Grindrod, Kelly, Beazely, Michael A.

“…A recent report found that the number of opioid-related deaths in Ontario in the first 15 weeks of the COVID-19 pandemic was 38.2% higher than in the 15 weeks…”
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Postsynaptic Clustering and Activation of Pyk2 by PSD-95 by Bartos, Jason A, Ulrich, Jason D, Li, Hongbin, Beazely, Michael A, Chen, Yucui, MacDonald, John F, Hell, Johannes W

“…The tyrosine kinase Pyk2 plays a unique role in intracellular signal transduction by linking Ca(2+) influx to tyrosine phosphorylation, but the molecular…”
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Reactive oxygen species are required for 5-HT-induced transactivation of neuronal platelet-derived growth factor and TrkB receptors, but not for ERK1/2 activation by Kruk, Jeff S, Vasefi, Maryam S, Heikkila, John J, Beazely, Michael A

“…High concentrations of reactive oxygen species (ROS) induce cellular damage, however at lower concentrations ROS act as intracellular second messengers. In…”
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5-HT7 receptor activation promotes an increase in TrkB receptor expression and phosphorylation by Samarajeewa, Anshula, Goldemann, Lolita, Vasefi, Maryam S, Ahmed, Nawaz, Gondora, Nyasha, Khanderia, Chandni, Mielke, John G, Beazely, Michael A

“…The serotonin (5-HT) type 7 receptor is expressed throughout the CNS including the cortex and hippocampus. We have previously demonstrated that the application…”
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The effects of heat and freeze-thaw cycling on naloxone stability by Lai, Dulcie, Pham, Amy Trinh, Nekkar Rao, Praveen P, Beazely, Michael A

“…The availability of take home naloxone (THN) was increased for Canadians in 2016, including access to kits via pharmacies. Unlike typical over-the-counter…”
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Platelet-derived Growth Factor Selectively Inhibits NR2B-containing N-Methyl-D-aspartate Receptors in CA1 Hippocampal Neurons by Beazely, Michael A., Lim, Aeni, Li, Hongbin, Trepanier, Catherine, Chen, XuanMao, Sidhu, Bikram, MacDonald, John F.

“…Platelet-derived growth factor (PDGF) β receptor activation inhibits N-methyl-d-aspartate (NMDA)-evoked currents in hippocampal and cortical neurons via the…”
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Acute 5-HT7 receptor activation increases NMDA-evoked currents and differentially alters NMDA receptor subunit phosphorylation and trafficking in hippocampal neurons by Vasefi, Maryam S, Yang, Kai, Li, Jerry, Kruk, Jeff S, Heikkila, John J, Jackson, Michael F, MacDonald, John F, Beazely, Michael A

“…N-methyl-D-aspartate (NMDA) receptors are regulated by several G protein-coupled receptors (GPCRs) as well as receptor tyrosine kinases. Serotonin (5-HT) type…”
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Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission by Yang, Kai, Trepanier, Catherine H., Li, Hongbin, Beazely, Michael A., Lerner, Ethan A., Jackson, Michael F., MacDonald, John F.

“…Vasoactive intestinal peptide (VIP) is a 28‐amino acid peptide, which belongs to a superfamily of structurally related peptide hormones including pituitary…”
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Drug–Drug Interaction of the Sodium Glucose Co-Transporter 2 Inhibitors with Statins and Myopathy: A Disproportionality Analysis Using Adverse Events Reporting Data by Alkabbani, Wajd, Pelletier, Ryan, Beazely, Michael A., Labib, Youssef, Quan, Breanna, Gamble, John-Michael

“…Introduction An increased risk of myopathy due to a potential interaction between sodium glucose co-transporter-2 inhibitors (SGLT-2i) and HMG-CoA reductase…”
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D2‐class dopamine receptor inhibition of NMDA currents in prefrontal cortical neurons is platelet‐derived growth factor receptor‐dependent by Beazely, Michael A., Tong, Andrew, Wei, Wen‐Li, Van Tol, Hubert, Sidhu, Bikram, MacDonald, John F.

“…NMDA receptor function is modulated by both G‐protein‐coupled receptors and receptor tyrosine kinases. In acutely isolated rat hippocampal neurons, direct…”
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Data on acylglycerophosphate acyltransferase 4 (AGPAT4) during murine embryogenesis and in embryo-derived cultured primary neurons and glia by Bradley, Ryan M., Mardian, Emily B., Marvyn, Phillip M., Vasefi, Maryam S., Beazely, Michael A., Mielke, John G., Duncan, Robin E.

“…Whole mouse embryos at three developmental timepoints, embryonic (E) day E10.5, E14.5, and E18.5, were analyzed for Agpat4 mRNA expression. Primary cortical…”
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Chronic early-life social isolation affects NMDA and TrkB receptor expression in a sex-specific manner by Gondora, Nyasha, Pople, Christopher B., Tandon, Gorvie, Robinson, Morgan, Solomon, Eden, Beazely, Michael A., Mielke, John G.

“…•Chronic early-life social isolation (CELSI) uniquely alters plasticity proteins.•CELSI increases TrkB expression in the HP and PFC of male, but not female,…”
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Protein kinase C and epidermal growth factor stimulation of Raf1 potentiates adenylyl cyclase type 6 activation in intact cells by Beazely, Michael A, Alan, Jamie K, Watts, Val J

“…Adenylyl cyclase type 6 (AC6) activity is inhibited by protein kinase C (PKC) in vitro; however, in intact cells, PKC activation does not inhibit the activity…”
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