Search Results - "Beavo, Joseph A."

Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use by Bender, Andrew T, Beavo, Joseph A

“…Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels of the second messengers, cAMP and cGMP, by controlling their rates…”
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Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy by Percival, Justin M, Whitehead, Nicholas P, Adams, Marvin E, Adamo, Candace M, Beavo, Joseph A, Froehner, Stanley C

“…Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy caused by mutations in the dystrophin gene. Loss of dystrophin initiates a…”
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Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy by Adamo, Candace M., Dai, Dao-Fu, Percival, Justin M., Minami, Elina, Willis, Monte S., Patrucco, Enrico, Froehner, Stanley C., Beavo, Joseph A.

“…Duchenne muscular dystrophy (DMD) is a progressive and fatal genetic disorder of muscle degeneration. Patients with DMD lack expression of the protein…”
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The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland by Tsai, Li-Chun Lisa, Shimizu-Albergine, Masami, Beavo, Joseph A

“…The functions of the phosphodiesterase 8B (PDE8) family of phosphodiesterases have been largely unexplored because of the unavailability of selective…”
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Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis by Patrucco, Enrico, Domes, Katrin, Sbroggió, Mauro, Blaich, Anne, Schlossmann, Jens, Desch, Matthias, Rybalkin, Sergei D, Beavo, Joseph A, Lukowski, Robert, Hofmann, Franz

“…Conflicting results have been reported for the roles of cGMP and cGMP-dependent protein kinase I (cGKI) in various pathological conditions leading to cardiac…”
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Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes by Lukowski, Robert, Rybalkin, Sergei D, Loga, Florian, Leiss, Veronika, Beavo, Joseph A, Hofmann, Franz

“…It has been suggested that cGMP kinase I (cGKI) dampens cardiac hypertrophy. We have compared the effect of isoproterenol (ISO) and transverse aortic…”
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Role of Ca2+/Calmodulin–Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy by Miller, Clint L, Oikawa, Masayoshi, Cai, Yujun, Wojtovich, Andrew P, Nagel, David J, Xu, Xiangbin, Xu, Haodong, Florio, Vince, Rybalkin, Sergei D, Beavo, Joseph A, Chen, Yiu-Fai, Li, Jian-Dong, Blaxall, Burns C, Abe, Jun-ichi, Yan, Chen

“…RATIONALE:Cyclic nucleotide phosphodiesterases (PDEs) through the degradation of cGMP play critical roles in maintaining cardiomyocyte homeostasis…”
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Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function by Rybalkin, Sergei D, Yan, Chen, Bornfeldt, Karin E, Beavo, Joseph A

“…ABSTRACT—Cyclic GMP (cGMP) made in response to atrial natriuretic peptide (ANP) or nitric oxide (NO) is an important regulator of short-term changes in smooth…”
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Differential Regulation of Endothelial Cell Permeability by cGMP via Phosphodiesterases 2 and 3 by Surapisitchat, James, Jeon, Kye-Im, Yan, Chen, Beavo, Joseph A

“…Endothelial barrier dysfunction leading to increased permeability and vascular leakage is an underlying cause of several pathological conditions, including…”
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Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A by Vasta, Valeria, Shimizu-Albergine, Masami, Beavo, Joseph A

“…Leydig cells produce testosterone in the testes under the pulsatile control of pituitary luteinizing hormone (LH). cAMP is the intracellular messenger for LH…”
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Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions by Soderling, Scott H, Beavo, Joseph A

“…The past eighteen months have provided much progress in the cyclic nucleotide phosphodiesterase (PDE) field. Six new phosphodiesterase genes have been…”
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Hydrolysis Products of cAMP Analogs Cause Transformation of Trypanosoma Brucei from Slender to Stumpy-Like Forms by Laxman, Sunil, Riecherst, Aaron, Sadilek, Martin, Schwede, Frank, Beavo, Joseph A.

“…African sleeping sickness is a disease caused by Trypanosoma brucei. T. brucei proliferate rapidly in the mammalian bloodstream as long, slender forms, but at…”
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Phosphodiesterase-8A binds to and regulates Raf-1 kinase by Brown, Kim M, Day, Jon P, Huston, Elaine, Zimmermann, Bastian, Hampel, Kornelia, Christian, Frank, Romano, David, Terhzaz, Selim, Lee, Louisa C Y, Willis, Miranda J, Morton, David B, Beavo, Joseph A, Shimizu-Albergine, Masami, Davies, Shireen A, Kolch, Walter, Houslay, Miles D, Baillie, George S

“…V-raf-1 murine leukemia viral oncogene homolog 1 (Raf-1) is a key activator of the ERK pathway and is a target for cross-regulation of this pathway by the cAMP…”
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Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages by Hertz, Angie L, Bender, Andrew T, Smith, Kimberly C, Gilchrist, Mark, Amieux, Paul S, Aderem, Alan, Beavo, Joseph A

“…Macrophages are central mediators of the innate immune system that can be differentiated from monocytes upon exposure to cytokines. While increased cyclic…”
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A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition by Demirbas, Didem, Wyman, Arlene R, Shimizu-Albergine, Masami, Cakici, Ozgur, Beavo, Joseph A, Hoffman, Charles S

“…A cell-based high-throughput screen (HTS) was developed to detect phosphodiesterase 8 (PDE8) and PDE4/8 combination inhibitors. By replacing the…”
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The Two GAF Domains in Phosphodiesterase 2A Have Distinct Roles in Dimerization and in cGMP Binding by Martinez, Sergio E., Wu, Albert Y., Glavas, Natalie A., Tang, Xiao-Bo, Turley, Stewart, Wim G. J. Hol, Beavo, Joseph A.

“…Cyclic nucleotide phosphodiesterases (PDEs) regulate all pathways that use cGMP or cAMP as a second messenger. Five of the 11 PDE families have regulatory…”
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The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change by Martinez, Sergio E., Heikaus, Clemens C., Klevit, Rachel E., Beavo, Joseph A.

“…The photoreceptor phosphodiesterase (PDE6) regulates the intracellular levels of the second messenger cGMP in the outer segments of cone and rod photoreceptor…”
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Regulation of cGMP-specific Phosphodiesterase (PDE5) Phosphorylation in Smooth Muscle Cells by Rybalkin, Sergei D., Rybalkina, Irina G., Feil, Robert, Hofmann, Franz, Beavo, Joseph A.

“…Nitric oxide and endogenous nitrovasodilators regulate smooth muscle tone by elevation of cGMP and activation of cyclic GMP-dependent protein kinase (PKG). The…”
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Isolation and Characterization of a Dual-Substrate Phosphodiesterase Gene Family: PDE10A by Soderling, Scott H., Bayuga, Sharon J., Beavo, Joseph A.

“…We report here the cloning, expression, and characterization of a dual-substrate, cAMP and cGMP, cyclic nucleotide phosphodiesterase (PDE) from mouse. This PDE…”
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Rosiglitazone Inhibits Acyl-CoA Synthetase Activity and Fatty Acid Partitioning to Diacylglycerol and Triacylglycerol via a Peroxisome Proliferator–Activated Receptor-γ–Independent Mechanism in Human Arterial Smooth Muscle Cells and Macrophages by ASKARI, Bardia, KANTER, Jenny E, SHERRID, Ashley M, GOLEJ, Deidre L, BENDER, Andrew T, LIU, Joey, HSUEH, Willa A, BEAVO, Joseph A, COLEMAN, Rosalind A, BORNFELDT, Karin E

“…Rosiglitazone Inhibits Acyl-CoA Synthetase Activity and Fatty Acid Partitioning to Diacylglycerol and Triacylglycerol via a Peroxisome Proliferator–Activated…”
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