Search Results - "Beavo, J. A."

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms by Beavo, J A

“…In the last few years there has been a veritable explosion of knowledge about cyclic nucleotide phosphodiesterases. In particular, the accumulating data…”
Get more information

Cloning and Characterization of a cAMP-Specific Cyclic Nucleotide Phosphodiesterase by Soderling, S. H., Bayuga, S. J., Beavo, J. A.

“…Cyclic nucleotide phosphodiesterases (PDEs) regulate intracellular levels of cAMP and cGMP by hydrolyzing them to their corresponding 5′monophosphates. We…”
Get full text

Inactivation of Pde8b enhances memory, motor performance, and protects against age‐induced motor coordination decay by Tsai, L.‐C. L., Chan, G. C.‐K., Nangle, S. N., Shimizu‐Albergine, M., Jones, G. L., Storm, D. R., Beavo, J. A., Zweifel, L. S.

“…Phosphodiesterase 8B is enriched in select brain regions and regulates learning, memory, and motor coordination. Phosphodiesterases (PDEs) are critical…”
Get full text

Cloning and Characterization of PDE7B, a cAMP-Specific Phosphodiesterase by Hetman, J. M., Soderling, S. H., Glavas, N. A., Beavo, J. A.

“…A member of the phosphodiesterase (PDE)7 family with high affinity and specificity for cAMP has been identified. Based on sequence homologies, we designate…”
Get full text

CD3- and CD28-Dependent Induction of PDE7 Required for T Cell Activation by Li, Linsong, Yee, Cassian, Beavo, Joseph A.

“…Costimulation of both the CD3 and CD28 receptors is essential for T cell activation. Induction of adenosine 3′,5′-monophosphate (cAMP)-specific…”
Get full text

Multiple cyclic nucleotide phosphodiesterases by Beavo, J A, Conti, M, Heaslip, R J

Get more information

Isolation and Characterization of a Dual-Substrate Phosphodiesterase Gene Family: PDE10A by Soderling, Scott H., Bayuga, Sharon J., Beavo, Joseph A.

“…We report here the cloning, expression, and characterization of a dual-substrate, cAMP and cGMP, cyclic nucleotide phosphodiesterase (PDE) from mouse. This PDE…”
Get full text

Regulation of adrenal steroidogenesis by the high-affinity phosphodiesterase 8 family by Tsai, L-C L, Beavo, J A

“…The main function of cyclic AMP phosphodiesterases (PDEs) is to degrade cAMP, a ubiquitous second messenger. Therefore, PDEs can function as prime regulators…”
Get more information

Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae by MICHAELI, T, BLOOM, T. J, MARTINS, T, LOUGHNEY, K, FERGUSON, K, RIGGS, M, RODGERS, L, BEAVO, J. A, WIGLER, M

“…We have established a highly sensitive functional screen for the isolation of cDNAs encoding cAMP phosphodiesterases (PDEs) by complementation of defects in a…”
Get full text

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors by Beavo, J A, Reifsnyder, D H

“…Primary sequence information has been reported for more than 15 different mammalian cyclic nucleotide phosphodiesterases. Moreover, recent observations suggest…”
Get more information

High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells by MacFarland, R T, Zelus, B D, Beavo, J A

“…An adrenal cGMP-stimulated phosphodiesterase (cGS-PDE) has been shown to mediate atrial natriuretic peptide (ANP)-induced reductions in aldosterone secretion…”
Get full text

Molecular Cloning and Characterization of a Calmodulin-Dependent Phosphodiesterase Enriched in Olfactory Sensory Neurons by Yan, Chen, Zhao, Allen Z., Bentley, J. Kelley, Loughney, Kate, Ferguson, Ken, Beavo, Joseph A.

“…The sensing of an odorant by an animal must be a rapid but transient process, requiring an instant response and also a speedy termination of the signal…”
Get full text

Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype by Rybalkin, S D, Bornfeldt, K E, Sonnenburg, W K, Rybalkina, I G, Kwak, K S, Hanson, K, Krebs, E G, Beavo, J A

“…The diversity among cyclic nucleotide phosphodiesterases provides multiple mechanisms for regulation of cAMP and cGMP in the cardiovascular system. Here we…”
Get full text

Characterization of a bovine cone photoreceptor phosphodiesterase purified by cyclic GMP-sepharose chromatography by Gillespie, P G, Beavo, J A

“…The biochemical bases for the differences in cone and rod photoreceptor physiology have not been thoroughly examined because of the difficulty in obtaining…”
Get full text

Stage and Cell-Specific Expression of Calmodulin-Dependent Phosphodiesterases in Mouse Testis by CHEN YAN, ZHAO, Allan Z, SONNENBURG, William K, BEAVO, Joseph A

“…Calcium and cyclic nucleotides are second messengers that regulate the development and functional activity of spermatozoa. Calcium/calmodulin-dependent…”
Get full text

Binding of the Delta Subunit to Rod Phosphodiesterase Catalytic Subunits Requires Methylated, Prenylated C-Termini of the Catalytic Subunits by Cook, Terry A, Ghomashchi, Farideh, Gelb, Michael H, Florio, Stephanie K, Beavo, Joseph A

“…PDE6 (type 6 phosphodiesterase) from rod outer segments consists of two types of catalytic subunits, alpha and beta; two inhibitory gamma subunits; and one or…”
Get full text

Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions by Soderling, Scott H, Beavo, Joseph A

“…The past eighteen months have provided much progress in the cyclic nucleotide phosphodiesterase (PDE) field. Six new phosphodiesterase genes have been…”
Get full text

Molecular cloning of a cDNA encoding the "61-kDa" calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms by SONNENBURG, W. K, SEGER, D, BEAVO, J. A

“…We have isolated a 2287-bp cDNA encoding the 61-kDa calmodulin-stimulated cyclic nucleotide phosphodiesterase (CaM PDE) from a bovine brain library. A large…”
Get full text

Molecular cloning of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase cDNA. Identification and distribution of isozyme variants by SONNENBURG, W. K, MULLANEY, P. J, BEAVO, J. A

“…We have cloned a 4.2-kilobase pair (kb) cDNA that encodes the cyclic GMP-stimulated phosphodiesterase (cGS PDE) from a bovine adrenal cortex library. The…”
Get full text

Phosphorylation-Dephosphorylation of Enzymes by Krebs, E G, Beavo, J A

Get full text