Search Results - "Beavil, Rebecca L"

Monitoring the systemic human memory B cell compartment of melanoma patients for anti-tumor IgG antibodies by Gilbert, Amy E, Karagiannis, Panagiotis, Dodev, Tihomir, Koers, Alexander, Lacy, Katie, Josephs, Debra H, Takhar, Pooja, Geh, Jenny L C, Healy, Ciaran, Harries, Mark, Acland, Katharine M, Rudman, Sarah M, Beavil, Rebecca L, Blower, Philip J, Beavil, Andrew J, Gould, Hannah J, Spicer, James, Nestle, Frank O, Karagiannis, Sophia N

“…Melanoma, a potentially lethal skin cancer, is widely thought to be immunogenic in nature. While there has been much focus on T cell-mediated immune responses,…”
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THE BIOLOGY OF IGE AND THE BASIS OF ALLERGIC DISEASE by Gould, Hannah J, Sutton, Brian J, Beavil, Andrew J, Beavil, Rebecca L, McCloskey, Natalie, Coker, Heather A, Fear, David, Smurthwaite, Lyn

“…Allergic individuals exposed to minute quantities of allergen experience an immediate response. Immediate hypersensitivity reflects the permanent sensitization…”
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Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor by Vester, Susan K, Davies, Anna M, Beavil, Rebecca L, Sandhar, Balraj S, Beavil, Andrew J, Gould, Hannah J, Sutton, Brian J, McDonnell, James M

“…We have previously produced a toolkit of antibodies, comprising recombinant human antibodies of all but one of the human isotypes, directed against the…”
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IgE Trimers Drive SPE-7 Cytokinergic Activity by Bax, Heather J., Bowen, Holly, Beavil, Rebecca L., Chung, Raymond, Ward, Malcolm, Davies, Anna M., Dodev, Tihomir S., McDonnell, James M., Beavil, Andrew J., Sutton, Brian J., Gould, Hannah J.

“…Degranulation of mast cells and basophils, with release of agents of the allergic response, ensues when multivalent antigens bind to and cross-link the cells’…”
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The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex by Bergeron, Julien R C, Huthoff, Hendrik, Veselkov, Dennis A, Beavil, Rebecca L, Simpson, Peter J, Matthews, Stephen J, Malim, Michael H, Sanderson, Mark R

“…The HIV-1 viral infectivity factor (Vif) protein recruits an E3 ubiquitin ligase complex, comprising the cellular proteins elongin B and C (EloBC), cullin 5…”
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Soluble CD23 Monomers Inhibit and Oligomers Stimulate IGE Synthesis in Human B Cells by McCloskey, Natalie, Hunt, James, Beavil, Rebecca L., Jutton, Mark R., Grundy, Gabrielle J., Girardi, Enrico, Fabiane, Stella M., Fear, David J., Conrad, Daniel H., Sutton, Brian J., Gould, Hannah J.

“…The low affinity IgE receptor, CD23, is implicated in IgE regulation and the pathogenesis of allergic disease. CD23 is a type II integral membrane protein,…”
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A Monomeric Chicken IgY Receptor Binds IgY with 2:1 Stoichiometry by Taylor, Alexander I., Beavil, Rebecca L., Sutton, Brian J., Calvert, Rosaleen A.

“…IgY is the principal serum antibody in birds and reptiles, and an IgY-like molecule was the evolutionary precursor of both mammalian IgG and IgE. A receptor…”
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Time-Resolved Fluorescence Anisotropy and Molecular Dynamics Analysis of a Novel GFP Homo-FRET Dimer by Teijeiro-Gonzalez, Yurema, Crnjar, Alessandro, Beavil, Andrew J., Beavil, Rebecca L., Nedbal, Jakub, Le Marois, Alix, Molteni, Carla, Suhling, Klaus

“…Förster resonance energy transfer (FRET) is a powerful tool to investigate the interaction between proteins in living cells. Fluorescence proteins, such as the…”
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The crystal structure of IgE Fc reveals an asymmetrically bent conformation by Sutton, Brian J, Wan, Tommy, Beavil, Rebecca L, Fabiane, Stella M, Beavil, Andrew J, Sohi, Maninder K, Keown, Maura, Young, Robert J, Henry, Alistair J, Owens, Ray J, Gould, Hannah J

“…The distinguishing structural feature of immunoglobulin E (IgE), the antibody responsible for allergic hypersensitivity, is the C epsilon 2 domain pair that…”
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FRET Sensor‐Modified Synthetic Hydrogels for Real‐Time Monitoring of Cell‐Derived Matrix Metalloproteinase Activity using Fluorescence Lifetime Imaging by Yan, Ziqian, Kavanagh, Thomas, da Silva Harrabi, Ricardo, Lust, Suzette T., Tang, Chunling, Beavil, Rebecca L., Müller, Manuel M., Beavil, Andrew J., Ameer‐Beg, Simon, da Silva, Ricardo M.P., Gentleman, Eileen

“…Matrix remodeling plays central roles in a range of physiological and pathological processes and is driven predominantly by the activity of matrix…”
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Crystal structures of the human IgD Fab reveal insights into CH1 domain diversity by Davies, Anna M., Beavil, Rebecca L., Barbolov, Momchil, Sandhar, Balraj S., Gould, Hannah J., Beavil, Andrew J., Sutton, Brian J., McDonnell, James M.

“…Antibodies of the IgD isotype remain the least well characterized of the mammalian immunoglobulin isotypes. Here we report three-dimensional structures for the…”
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Nucleolin acts as the receptor for C1QTNF4 and supports C1QTNF4-mediated innate immunity modulation by Vester, Susan K., Beavil, Rebecca L., Lynham, Steven, Beavil, Andrew J., Cunninghame Graham, Deborah S., McDonnell, James M., Vyse, Timothy J.

“…The C1q and TNF related 4 (C1QTNF4) protein is a structurally unique member of the C1QTNF family, a family of secreted proteins that have structural homology…”
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Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes by Sayers, Sophie R., Beavil, Rebecca L., Fine, Nicholas H. F., Huang, Guo C., Choudhary, Pratik, Pacholarz, Kamila J., Barran, Perdita E., Butterworth, Sam, Mills, Charlotte E., Cruickshank, J. Kennedy, Silvestre, Marta P., Poppitt, Sally D., McGill, Anne-Thea, Lavery, Gareth G., Hodson, David J., Caton, Paul W.

“…Aims/hypothesis Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular…”
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Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition by Mitropoulou, Alkistis N., Bowen, Holly, Dodev, Tihomir S., Davies, Anna M., Bax, Heather J., Beavil, Rebecca L., Beavil, Andrew J., Gould, Hannah J., James, Louisa K., Sutton, Brian J.

“…Antibodies classically bind antigens via their complementarity-determining regions, but an alternative mode of interaction involving V-domain framework regions…”
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Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody by Chen, Jiun-Bo, Ramadani, Faruk, Pang, Marie O. Y., Beavil, Rebecca L., Holdom, Mary D., Mitropoulou, Alkistis N., Beavil, Andrew J., Gould, Hannah J., Chang, Tse Wen, Sutton, Brian J., McDonnell, James M., Davies, Anna M.

“…Immunoglobulin E (IgE) antibodies play a central role in the allergic response: interaction with FcεRI on mast cells and basophils leads to immediate…”
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The effect of the adaptor protein Isd11 on the quaternary structure of the eukaryotic cysteine desulphurase Nfs1 by Teralı, Kerem, Beavil, Rebecca L., Pickersgill, Richard W., van der Giezen, Mark

“…•We have produced soluble yeast Nfs1 both alone and in complex with yeast Isd11.•Isd11 binds Nfs1 in a stoichiometric ratio of 1:1.•Nfs1 is a homodimer in the…”
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A fluorescent biosensor reveals conformational changes in human immunoglobulin E Fc: implications for mechanisms of receptor binding, inhibition, and allergen recognition by Hunt, James, Keeble, Anthony H, Dale, Robert E, Corbett, Melissa K, Beavil, Rebecca L, Levitt, James, Swann, Marcus J, Suhling, Klaus, Ameer-Beg, Simon, Sutton, Brian J, Beavil, Andrew J

“…IgE binding to its high affinity receptor FcεRI on mast cells and basophils is a key step in the mechanism of allergic disease and a target for therapeutic…”
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IgE-Antibody-Dependent Immunotherapy of Solid Tumors: Cytotoxic and Phagocytic Mechanisms of Eradication of Ovarian Cancer Cells by Karagiannis, Sophia N, Bracher, Marguerite G, Hunt, James, McCloskey, Natalie, Beavil, Rebecca L, Beavil, Andrew J, Fear, David J, Thompson, Richard G, East, Nicholas, Burke, Frances, Moore, Robert J, Dombrowicz, David D, Balkwill, Frances R, Gould, Hannah J

“…Abs have a paramount place in the treatment of certain, mainly lymphoid, malignancies, although tumors of nonhemopoietic origin have proved more refractory…”
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The structure of human CD23 and its interactions with IgE and CD21 by Hibbert, Richard G, Teriete, Peter, Grundy, Gabrielle J, Beavil, Rebecca L, Reljic, Rajko, Holers, V Michael, Hannan, Jonathan P, Sutton, Brian J, Gould, Hannah J, McDonnell, James M

“…The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcepsilonRII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE,…”
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Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA by Hands-Taylor, Katherine L.D, Martino, Luigi, Tata, Renée, Babon, Jeffrey J, Bui, Tam T, Drake, Alex F, Beavil, Rebecca L, Pruijn, Ger J.M, Brown, Paul R, Conte, Maria R

“…Rpp20 and Rpp25 are two key subunits of the human endoribonucleases RNase P and MRP. Formation of an Rpp20-Rpp25 complex is critical for enzyme function and…”
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