Search Results - "Beavil, R L"

Regulation of IgE Production Requires Oligomerization of CD23 by Kilmon, Michelle A, Ghirlando, Rodolfo, Strub, Marie-Paule, Beavil, Rebecca L, Gould, Hannah J, Conrad, Daniel H

“…Here we describe the production of a rabbit polyclonal Ab (RAS1) raised against the stalk of murine CD23. RAS1 inhibits release of CD23 from the surface of…”
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THE BIOLOGY OF IGE AND THE BASIS OF ALLERGIC DISEASE by Gould, Hannah J, Sutton, Brian J, Beavil, Andrew J, Beavil, Rebecca L, McCloskey, Natalie, Coker, Heather A, Fear, David, Smurthwaite, Lyn

“…Allergic individuals exposed to minute quantities of allergen experience an immediate response. Immediate hypersensitivity reflects the permanent sensitization…”
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CD23/Fc epsilon RII and its soluble fragments can form oligomers on the cell surface and in solution by Beavil, R L, Graber, P, Aubonney, N, Bonnefoy, J Y, Gould, H J

“…Human CD23 (also known as Fc epsilon RII) is a 45,000 MW glycoprotein with homology to C-type animal lectins. It is involved in B-cell differentiation and IgE…”
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The crystal structure of IgE Fc reveals an asymmetrically bent conformation by Sutton, Brian J, Wan, Tommy, Beavil, Rebecca L, Fabiane, Stella M, Beavil, Andrew J, Sohi, Maninder K, Keown, Maura, Young, Robert J, Henry, Alistair J, Owens, Ray J, Gould, Hannah J

“…The distinguishing structural feature of immunoglobulin E (IgE), the antibody responsible for allergic hypersensitivity, is the C epsilon 2 domain pair that…”
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Structural basis of the IgE-Fc epsilon RI interaction by Beavil, A J, Beavil, R L, Chan, C M, Cook, J P, Gould, H J, Henry, A J, Owens, R J, Shi, J, Sutton, B J, Young, R J

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Automated hydrodynamic modelling of a complex between a human IgE fragment (Fc epsilon 3-4) and the IgE high affinity receptor Fc epsilon RI alpha-chain by Beavil, A J, Beavil, R L

“…The binding of IgE to its high affinity receptor Fc epsilon RI plays an important role in the allergic response. The interaction between soluble Fc epsilon RI…”
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Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble by Yiu, C.-P. Benny, Beavil, Rebecca L., Chan, H.Y. Edwin

“…Dribble (DBE) is an essential protein in Drosophila that belongs to the evolutionarily conserved Krr1p protein family. Proteins in this family are localised in…”
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Cleavage of the low-affinity receptor for human IgE (CD23) by a mite cysteine protease: nature of the cleaved fragment in relation to the structure and function of CD23 by Schulz, O, Sutton, B J, Beavil, R L, Shi, J, Sewell, H F, Gould, H J, Laing, P, Shakib, F

“…Der p I, a cysteine protease representing a major allergen of the house dust mite Dermatophagoides pteronyssinus, has recently been shown to cleave CD23 from…”
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Interaction of the low-affinity receptor CD23/Fc epsilon RII lectin domain with the Fc epsilon 3-4 fragment of human immunoglobulin E by Shi, Jianguo, Ghirlando, R, Beavil, R L, Beavil, A J, Keown, M B, Young, R J, Owens, R J, Sutton, B J, Gould, HJ

“…CD23/Fc epsilon RII, the low-affinity receptor for IgE, is a multifunctional protein of importance in blood cell development and the immune system. We have…”
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IgE isotype determination: epsilon-germline gene transcription, DNA recombination and B-cell differentiation by Gould, H J, Beavil, R L, Vercelli, D

“…Immunoglobulin class switching is the process which determines whether a B-cell secretes antibodies of the IgM, IgG, IgA or IgE class (or isotype). IgE is the…”
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Mutagenesis Within Human FcεRIα Differentially Affects Human and Murine IgE Binding by Mackay, Graham A., Hulett, Mark D., Cook, Justin P. D., Trist, Halina M., Henry, Alistair J., McDonnell, James M., Beavil, Andrew J., Beavil, Rebecca L., Sutton, Brian J., Hogarth, P. Mark, Gould, Hannah J.

“…Soluble fragments of the α-chain of FcεRI, the high-affinity receptor for IgE, compete with membrane-bound receptors for IgE and may thus provide a means to…”
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Inhibition of IgE-receptor interactions by Sutton, B J, Beavil, R L, Beavil, A J

“…Immunoglobulin E plays a central role in allergic disease and, as our understanding of the network of interactions between IgE and its receptors improves, new…”
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Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells by Karagiannis, Sophia N., Bracher, Marguerite G., Beavil, Rebecca L., Beavil, Andrew J., Hunt, James, McCloskey, Natalie, Thompson, Richard G., East, Nicholas, Burke, Frances, Sutton, Brian J., Dombrowicz, David, Balkwill, Frances R., Gould, Hannah J.

“…Antibodies directed against tumor-associated antigens are emerging as effective treatments for a number of cancers, although the mechanism(s) of action for…”
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sub(L)-Methionine Sulfoximine, but Not Phosphinothricin, Is a Substrate for an Acetyltransferase (Gene PA4866) from Pseudomonas aeruginosa: Structural and Functional Studies by Davies, A M, Tata, R, Beavil, R L, Sutton, B J, Brown, PR

“…The gene PA4866 from Pseudomonas aemginosa is documented in the Pseudomonas genome database as encoding a 172 amino acid hypothetical acetyltransferase. We and…”
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The structure of human CD23 and its interactions with IgE and CD21 by Hibbert, Richard G, Teriete, Peter, Grundy, Gabrielle J, Beavil, Rebecca L, Reljic, Rajko, Holers, V Michael, Hannan, Jonathan P, Sutton, Brian J, Gould, Hannah J, McDonnell, James M

“…The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcepsilonRII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE,…”
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lgE isotype determination:  -germline gene transcription, DNA recombination and B-cell differentiation by Gould, H. J, Beavil, R. L, Vercelli, D.

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Automated hydrodynamic modelling of a complex between a human IgE fragment (FcÂ3-4) and the IgE high affinity receptor FcÂRI ⋅-chain by Beavil, A. J., Beavil, R. L.

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Inhibition of lgE-receptor interactions by Sutton, Brain J, Beavil, Rebecca L, Beavil, Andrew J

“…Immunoglobulin E plays a central role in allergic disease and, as our undrestanding of the network of interactions between lgE and its receptors impproves, new…”
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Interaction of the low-affinity receptor CD23/Fc epsilonRII lectin domain with the Fc epsilon3-4 fragment of human immunoglobulin E by Shi, J, Ghirlando, R, Beavil, R L, Beavil, A J, Keown, M B, Young, R J, Owens, R J, Sutton, B J, Gould, H J

“…CD23/Fc epsilonRII, the low-affinity receptor for IgE, is a multifunctional protein of importance in blood cell development and the immune system. We have…”
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The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha by McDonnell, J M, Calvert, R, Beavil, R L, Beavil, A J, Henry, A J, Sutton, B J, Gould, H J, Cowburn, D

“…The stability of the complex between IgE and its high-affinity receptor, FcepsilonRI, on mast cells is a critical factor in the allergic response. The long…”
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