Search Results - "Beavers, David L."

Mutation E169K in Junctophilin-2 Causes Atrial Fibrillation Due to Impaired RyR2 Stabilization by Beavers, David L., BS, Wang, Wei, PhD, Ather, Sameer, MD, PhD, Voigt, Niels, MD, Garbino, Alejandro, MD, PhD, Dixit, Sayali S., PhD, Landstrom, Andrew P., MD, PhD, Li, Na, PhD, Wang, Qiongling, PhD, Olivotto, Iacopo, MD, Dobrev, Dobromir, MD, Ackerman, Michael J., MD, PhD, Wehrens, Xander H.T., MD, PhD

“…Objectives This study sought to study the role of junctophilin-2 (JPH2) in atrial fibrillation (AF). Background JPH2 is believed to have an important role in…”
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Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases by Beavers, David L, Landstrom, Andrew P, Chiang, David Y, Wehrens, Xander H T

“…Cardiomyocytes rely on a highly specialized subcellular architecture to maintain normal cardiac function. In a little over a decade, junctophilin-2 (JPH2) has…”
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The junctophilin family of proteins: from bench to bedside by Landstrom, Andrew P, Beavers, David L, Wehrens, Xander H.T

“…Highlights • Junctophilins are a conserved family of proteins found in all excitable cells. • Junctophilins maintain subcellular architecture and calcium…”
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Loss of MicroRNA-106b-25 Cluster Promotes Atrial Fibrillation by Enhancing Ryanodine Receptor Type-2 Expression and Calcium Release by Chiang, David Y, Kongchan, Natee, Beavers, David L, Alsina, Katherina M, Voigt, Niels, Neilson, Joel R, Jakob, Heinz, Martin, James F, Dobrev, Dobromir, Wehrens, Xander H.T, Li, Na

“…BACKGROUND—Enhanced sarcoplasmic reticulum Ca-leak via ryanodine receptor type-2 (RyR2) contributes to the pathogenesis of atrial fibrillation (AF). Recent…”
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Alterations in the Interactome of Serine/Threonine Protein Phosphatase Type-1 in Atrial Fibrillation Patients by Chiang, David Y., PhD, Lebesgue, Nicolas, MSc, Beavers, David L., PhD, Alsina, Katherina M., BA, Damen, J. Mirjam A., BSc, Voigt, Niels, MD, Dobrev, Dobromir, MD, Wehrens, Xander H.T., MD, PhD, Scholten, Arjen, PhD

“…Abstract Background Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, yet current pharmacological treatments are limited…”
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Wearables in Sports Cardiology by Beavers, David L., Chung, Eugene H.

“…The expanding array and adoption of consumer health wearables is creating a new dynamic to the patient–health-care provider relationship. Providers are…”
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Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release by Reynolds, Julia O., Quick, Ann P., Wang, Qiongling, Beavers, David L., Philippen, Leonne E., Showell, Jordan, Barreto-Torres, Giselle, Thuerauf, Donna J., Doroudgar, Shirin, Glembotski, Christopher C., Wehrens, Xander H.T.

“…Junctophilin-2 (JPH2) is the primary structural protein for the coupling of transverse (T)-tubule associated cardiac L-type Ca channels and type-2 ryanodine…”
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Diagnosis, significance, and management of ventricular thrombi in patients referred for VT ablation by Beavers, David L., Ghannam, Michael, Liang, Jackson, Cochet, Hubert, Attili, Anil, Sharaf‐Dabbagh, Ghaith, Latchamsetty, Rakesh, Jongnarangsin, Krit, Morady, Fred, Bogun, Frank

“…Introduction In patients with structural heart disease presenting with ventricular tachycardia (VT), detection of ventricular thrombi and subsequent management…”
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Junctophilin-2 is necessary for T-tubule maturation during mouse heart development by Reynolds, Julia O, Chiang, David Y, Wang, Wei, Beavers, David L, Dixit, Sayali S, Skapura, Darlene G, Landstrom, Andrew P, Song, Long-Sheng, Ackerman, Michael J, Wehrens, Xander H T

“…Transverse tubules (TTs) provide the basic subcellular structures that facilitate excitation-contraction (EC) coupling, the essential process that underlies…”
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Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome by McCauley, Mark D, Wang, Tiannan, Mike, Elise, Herrera, Jose, Beavers, David L, Huang, Teng-Wei, Ward, Christopher S, Skinner, Steven, Percy, Alan K, Glaze, Daniel G, Wehrens, Xander H T, Neul, Jeffrey L

“…Rett syndrome is a neurodevelopmental disorder typically caused by mutations in methyl-CpG-binding protein 2 (MECP2) in which 26% of deaths are sudden and of…”
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Novel Junctophilin-2 Mutation A405S Is Associated With Basal Septal Hypertrophy and Diastolic Dysfunction by Quick, Ann P., BA, Landstrom, Andrew P., MD, PhD, Wang, Qiongling, PhD, Beavers, David L., MD, PhD, Reynolds, Julia O., BS, Barreto-Torres, Giselle, PhD, Tran, Viet, MD, Showell, Jordan, BS, Philippen, Leonne E., MSc, Morris, Shaine A., MD, MPH, Skapura, Darlene, BS, Bos, J. Martijn, MD, Pedersen, Steen E., PhD, Pautler, Robia G., PhD, Ackerman, Michael J., MD, PhD, Wehrens, Xander H.T., MD, PhD

“…Visual Abstract…”
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Abstract 35: Pseudo-knockin Mice Expressing JPH2-A399S Develop Cardiac Hypertrophy by Magnetic Resonance Imaging by Quick, Ann P, Beavers, David L, Showell, Jordan, Philippen, Leonne E, Landstrom, Andrew P, Morris, Shaine A, Pautler, Robia G, Wehrens, Xander H

“…Abstract only Background: Dysfunctional intracellular Ca2+ handling has been implicated in adverse cardiac remodeling leading to hypertrophy and failure…”
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Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca 2 + release by Reynolds, Julia O, Quick, Ann P, Wang, Qiongling, Beavers, David L, Philippen, Leonne E, Showell, Jordan, Barreto-Torres, Giselle, Theurauf, Donna J, Doroudgar, Shirin, Glembotski, Christopher C, Wehrens, Xander H.T

“…Abstract Background Junctophilin-2 (JPH2) is the primary structural protein for coupling of transverse (T)-tubule associated cardiac L-type Ca channels and…”
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