Search Results - "Beaumier, P. L."

Cure of Human Carcinoma Xenografts by a Single Dose of Pretargeted Yttrium-90 with Negligible Toxicity by Axworthy, D. B., Reno, J. M., Hylarides, M. D., Mallett, R. W., Theodore, L. J., Gustavson, L. M., F.-M. Su, Hobson, L. J., Beaumier, P. L., Fritzberg, A. R.

“…A covalent conjugate (NR-LU-10/SA) was prepared between streptavidin (SA) and NR-LU-10, a mAb that binds an antigen expressed on the surface of most human…”
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Specific and Stable Labeling of Antibodies with Technetium-99m with a Diamide Dithiolate Chelating Agent by Fritzberg, Alan R., Abrams, Paul G., Beaumier, Paul L., Kasina, Sudhakar, Morgan, A. Charles, Rao, T. N., Reno, John M., Sanderson, James A., Srinivasan, A., Wilbur, D. Scott, Vanderheyden, Jean-Luc

“…Technetium-99m labeling of antibodies has been suboptimal because of low affinity adventitious binding, nonspecific labeling, and loss of immunoreactivity. The…”
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Antitumor Effects of L6, an IgG2a Antibody that Reacts with Most Human Carcinomas by Hellström, Ingegerd, Beaumier, Paul L., Hellström, Karl Erik

“…Mouse monoclonal antibody L6 (IgG2a sub-type) recognizes a ganglioside antigen expressed at the surface of cells from human non-small-cell lung carcinomas,…”
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Use of I-131 labeled, murine Fab against a high molecular weight antigen of human melanoma: preliminary experience by Larson, S M, Carrasquillo, J A, McGuffin, R W, Krohn, K A, Ferens, J M, Hill, L D, Beaumier, P L, Reynolds, J C, Hellström, K E, Hellström, I

“…High molecular weight antigen (HMWA) is a tumor-associated proteoglycan of human malignant melanoma. I-131 labeled Fab fragments of these specific antibodies…”
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Rhenium-186-Labeled Chimeric Antibody NR-LU-13: Pharmacokinetics, Biodistribution and Immunogenicity Relative to Murine Analog NR-LU-10 by Weiden, Paul L, Breitz, Hazel B, Seiler, Christine A, Bjorn, Michael J, Ratliff, Barbara A, Mallett, Robert, Beaumier, Paul L, Appelbaum, Janet W, Fritzberg, Alan R, Salk, Darrell

“…A mouse-human chimeric monoclonal antibody (NR-LU-13), with the same pancarcinoma antigen recognition site as a previously studied murine monoclonal antibody…”
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Hepatic Uptake and Degradation of Unilamellar Sphingomyelin/Cholesterol Liposomes: A Kinetic Study by Hwang, Karl J., Luk, Kuen-Fai S., Beaumier, Paul L.

“…The kinetics of hepatic uptake and degradation of sphingomyelin/cholesterol (2:1, M/M) small unilamellar liposomes were investigated in a BALB/c mouse. The…”
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Uptake of small liposomes by non-reticuloendothelial tissues by Hwang, K J, Padki, M M, Chow, D D, Essien, H E, Lai, J Y, Beaumier, P L

“…The distribution of liposomes within the intravascular space and the extent to which they escape into extravascular space strongly impact on the application of…”
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Preliminary Studies of Monoclonal Antibody Lymphoscintigraphy in Malignant Melanoma by Nelp, W.B, Eary, J.F, Jones, R.F, Hellstrom, K.E, Hellstrom, I, Beaumier, P.L, Krohn, K.A

“…Lymphoscintigraphy was performed at 3 and 20 hr following subcutaneous injection of 131I anti-melanoma antibody (Fab) in 11 patients who had surgical resection…”
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Development and Biologic Evaluation of a Kit for Preformed Chelate Technetium-99m Radiolabeling of an Antibody Fab Fragment Using a Diamide Dimercaptide Chelating Agent by Kasina, Sudhakar, Rao, Tripuraneni N, Srinivasan, Ananthachari, Sanderson, James A, Fitzner, Jeffrey N, Reno, John M, Beaumier, Paul L, Fritzberg, Alan R

“…A kit has been developed for 99mTc antibody radiolabeling via defined chemistry using an N2S2 diamide dimercaptide bifunctional chelating agent and the…”
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High-Level Iodination of Monoclonal Antibody Fragments for Radiotherapy by Ferens, John M, Krohn, Kenneth A, Beaumier, Paul L, Brown, Joseph P, Hellstrom, Ingegerd, Hellstrom, Karl Erik, Carrasquillo, Jorge A, Larson, Steven M

“…Two different murine monoclonal antibody Fab fragments specific for p97, a melanoma-associated antigen, were labeled with I-131 at high activity levels without…”
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Clinical Optimization of Pretargeted Radioimmunotherapy with Antibody-Streptavidin Conjugate and 90Y-DOTA-Biotin by Breitz, Hazel B, Weiden, Paul L, Beaumier, Paul L, Axworthy, Donald B, Seiler, Chris, Su, Fu-Min, Graves, Scott, Bryan, Kyle, Reno, John M

“…Pretargeted radioimmunotherapy (PRIT) was evaluated using an antibody-streptavidin conjugate, followed by a biotin-galactose-human serum albumin clearing agent…”
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Dosimetry of Rhenium-186-Labeled Monoclonal Antibodies: Methods, Prediction from Technetium-99m-Labeled Antibodies and Results of Phase I Trials by Breitz, Hazel B, Fisher, Darrell R, Weiden, Paul L, Durham, James S, Ratliff, Barbara A, Bjorn, Michael J, Beaumier, Paul L, Abrams, Paul G

“…Rhenium-186 is a beta-emitting radionuclide that has been studied for applications in radioimmunotherapy. Its 137 keV gamma photon is ideal for imaging the…”
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Kinetic evidences of enhancing interaction of small liposomes with hepatic parenchymal cells mediated by large liposomes blockade by Hwang, K J, Beaumier, P L

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Simplified Preformed Chelate Protein Radiolabeling with Technetium-99m Mercaptoacetamidoadipoylglycylglycine (N3S-Adipate) by Kasina, Sudhakar, Sanderson, James A, Fitzner, Jeffrey N, Srinivasan, Ananthachari, Rao, Tripuraneni N, Hobson, Lori J, Reno, John M, Axworthy, Donald B, Beaumier, Paul L, Fritzberg, Alan R

“…A simplified kiet has been developed for 99mTc protein radiolabeling using an N3S triamide mercaptide bifunctional chelating agent and the preformed chelate…”
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Targeted proteins for diagnostic imaging: does chemistry make a difference? by Fritzberg, A R, Beaumier, P L

“…The Oyen et al. study is valuable in that it systematically evaluates several of the factors involved in radiolabeled protein uptake and retention in…”
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Optimal antibody-radionuclide combinations for clinical radioimmunotherapy: a predictive model based on mouse pharmacokinetics by Yorke, E D, Beaumier, P L, Wessels, B W, Fritzberg, A R, Morgan, Jr, A C

“…A theoretical comparison was made of radioimmunotherapy (RIT) dosimetry estimates for eight radionuclides (90Y, 105Rh, 131I, 153Sm, 186Re, 188Re, 198Au, 211At)…”
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An Efficient Method for Loading Indium-111 into Liposomes Using Acetylacetone by Beaumier, Paul L, Hwang, Karl J

“…The efficient loading of high levels of In-111 into the inner aqueous compartment of liposomes can be achieved using a water-soluble lipophilic chelate,…”
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Effect of liposome dose on the elimination of small unilamellar sphingomyelin/cholesterol vesicles from the circulation by Beaumier, P L, Hwang, K J, Slattery, J T

“…The effect of the liposome dose of bovine brain sphingomyelin/cholesterol (2/1; mol/mol) small unilamellar vesicles (mean diameter 187 42A) on the rate of…”
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Immunoreactivity Assay for Labeled Anti-Melanoma Monoclonal Antibodies by Beaumier, Paul L, Neuzil, Dan, Yang, Hsin M, Noll, Elisabeth A, Kishore, Raj, Eary, Janet F, Krohn, Kenneth A, Nelp, Wil B, Hellstrom, Karl Erik, Hellstrom, Ingegerd

“…A convenient, rapid, and reproducible assay was developed to evaluate the immunoreactivity of radiolabeled monoclonal antibodies against three different human…”
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186Re radioimmunotherapy of small cell lung carcinoma xenografts in nude mice by BEAUMIER, P. L, VENKATESAN, P, VANDERHEYDEN, J.-L, BURGUA, W. D, KUNZ, L. L, FRITZBERG, A. R, ABRAMS, P. G, MORGAN, A. C

“…A 186Re-labeled monoclonal antibody (MAb), NR-LU-10, was used for the radioimmunotherapy of a subcutaneous human small cell lung carcinoma xenograft, SHT-1, in…”
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