Search Results - "Beaudoin, Jennifer A."

Diversity-Oriented Synthesis Probe Targets Plasmodium falciparum Cytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors by Lukens, Amanda K., Heidebrecht, Richard W., Mulrooney, Carol, Beaudoin, Jennifer A., Comer, Eamon, Duvall, Jeremy R., Fitzgerald, Mark E., Masi, Daniela, Galinsky, Kevin, Scherer, Christina A., Palmer, Michelle, Munoz, Benito, Foley, Michael, Schreiber, Stuart L., Wiegand, Roger C., Wirth, Dyann F.

“…Background. The emergence and spread of drug resistance to current antimalarial therapies remains a pressing concern, escalating the need for compounds that…”
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Diversity-Oriented Synthesis-Facilitated Medicinal Chemistry: Toward the Development of Novel Antimalarial Agents by Comer, Eamon, Beaudoin, Jennifer A, Kato, Nobutaka, Fitzgerald, Mark E, Heidebrecht, Richard W, Lee, Maurice duPont, Masi, Daniela, Mercier, Marion, Mulrooney, Carol, Muncipinto, Giovanni, Rowley, Ann, Crespo-Llado, Keila, Serrano, Adelfa E, Lukens, Amanda K, Wiegand, Roger C, Wirth, Dyann F, Palmer, Michelle A, Foley, Michael A, Munoz, Benito, Scherer, Christina A, Duvall, Jeremy R, Schreiber, Stuart L

“…Here, we describe medicinal chemistry that was accelerated by a diversity-oriented synthesis (DOS) pathway, and in vivo studies of our previously reported…”
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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria by Heidebrecht, Richard W, Mulrooney, Carol, Austin, Christopher P, Barker, Robert H, Beaudoin, Jennifer A, Cheng, Ken Chih-Chien, Comer, Eamon, Dandapani, Sivaraman, Dick, Justin, Duvall, Jeremy R, Ekland, Eric H, Fidock, David A, Fitzgerald, Mark E, Foley, Michael, Guha, Rajarshi, Hinkson, Paul, Kramer, Martin, Lukens, Amanda K, Masi, Daniela, Marcaurelle, Lisa A, Su, Xin-Zhuan, Thomas, Craig J, Weïwer, Michel, Wiegand, Roger C, Wirth, Dyann, Xia, Menghang, Yuan, Jing, Zhao, Jinghua, Palmer, Michelle, Munoz, Benito, Schreiber, Stuart

“…Here, we describe the discovery of a novel antimalarial agent using phenotypic screening of Plasmodium falciparum asexual blood-stage parasites. Screening a…”
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Synthesis of a d-Ala-d-Ala peptide isostere via olefin cross-metathesis and evaluation of vancomycin binding by Quinn, Ryan K., Cianci, Amelia L., Beaudoin, Jennifer A., Sculimbrene, Bianca R.

“…The alkene peptide isostere for the d-Ala-d-Ala dipeptide was synthesized via a convergent approach utilizing olefin cross-metathesis. The new isostere was…”
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Synthesis of aD-Ala-D-Ala peptide isostere via olefin cross-metathesis and evaluation of vancomycin binding by QUINN, Ryan K, CIANCI, Amelia L, BEAUDOIN, Jennifer A, SCULIMBRENE, Bianca R

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