Search Results - "Beauchemin, Catherine A.A."

Impact of the H275Y and I223V Mutations in the Neuraminidase of the 2009 Pandemic Influenza Virus In Vitro and Evaluating Experimental Reproducibility by Paradis, Eric G, Pinilla, Lady Tatiana, Holder, Benjamin P, Abed, Yacine, Boivin, Guy, Beauchemin, Catherine A A

“…The 2009 pandemic H1N1 (H1N1pdm09) influenza virus is naturally susceptible to neuraminidase (NA) inhibitors, but mutations in the NA protein can cause…”
Get full text

Neuraminidase inhibitors for treatment of human and avian strain influenza: A comparative modeling study by Dobrovolny, Hana M., Gieschke, Ronald, Davies, Brian E., Jumbe, Nelson L., Beauchemin, Catherine A.A.

“…Treatment of seasonal influenza viral infections using antivirals such as neuraminidase inhibitors (NAIs) has been proven effective if administered within 48h…”
Get full text

Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding SR-B1 by Fung, Karen Y.Y., Ho, Tse Wing Winnie, Xu, Zizhen, Neculai, Dante, Beauchemin, Catherine A.A., Lee, Warren L., Fairn, Gregory D.

“…Atherosclerosis results from the deposition and oxidation of LDL and immune cell infiltration in the sub-arterial space leading to arterial occlusion. Studies…”
Get full text

Uncovering critical properties of the human respiratory syncytial virus by combining in vitro assays and in silico analyses by Beauchemin, Catherine A A, Kim, Young-In, Yu, Qin, Ciaramella, Giuseppe, DeVincenzo, John P

“…Many aspects of the respiratory syncytial virus (RSV) are still poorly understood. Yet these knowledge gaps have had and could continue to have adverse,…”
Get full text

Quantifying mechanistic traits of influenza viral dynamics using in vitro data by Yan, Ada W.C., Zhou, Jie, Beauchemin, Catherine A.A., Russell, Colin A., Barclay, Wendy S., Riley, Steven

“…When analysing in vitro data, growth kinetics of influenza virus strains are often compared by computing their growth rates, which are sometimes used as…”
Get full text

A conservation law for virus infection kinetics in vitro by Kakizoe, Yusuke, Morita, Satoru, Nakaoka, Shinji, Takeuchi, Yasuhiro, Sato, Kei, Miura, Tomoyuki, Beauchemin, Catherine A A, Iwami, Shingo

“…Conservation laws are among the most important properties of a physical system, but are not commonplace in biology. We derived a conservation law from the…”
Get full text

I222V Neuraminidase Mutation Has a Compensatory Role in Replication of an Oseltamivir-Resistant Influenza Virus A/H3N2 E119V Mutant by Simon, Philippe, Holder, Benjamin P, Bouhy, Xavier, Abed, Yacine, Beauchemin, Catherine A.A, Boivin, Guy

“…Oseltamivir-resistant A/H3N2 influenza isolates with or without the E119V and I222V neuraminidase (NA) mutations were recovered from an immunocompromised…”
Get full text

Progress and trends in mathematical modelling of influenza A virus infections by Handel, Andreas, Liao, Laura E., Beauchemin, Catherine A.A.

“…Mathematical modelling of influenza A virus infection has seen increased use over the last several years. Models applied to both in vitro and in vivo data have…”
Get full text

Exploring associations between viral titer measurements and disease outcomes in ferrets inoculated with 125 contemporary influenza A viruses by Kieran, Troy J, Sun, Xiangjie, Maines, Taronna R, Beauchemin, Catherine A A, Belser, Jessica A

“…As use of the ferret model to study influenza A virus (IAV) pathogenicity increases, periodic assessment of data generated in this model is warranted, to…”
Get full text

A review of mathematical models of influenza A infections within a host or cell culture: lessons learned and challenges ahead by Beauchemin, Catherine A A, Handel, Andreas

“…Most mathematical models used to study the dynamics of influenza A have thus far focused on the between-host population level, with the aim to inform public…”
Get full text

Duration of SHIV production by infected cells is not exponentially distributed: Implications for estimates of infection parameters and antiviral efficacy by Beauchemin, Catherine A. A., Miura, Tomoyuki, Iwami, Shingo

“…The duration of the eclipse phase, from cell infection to the production and release of the first virion progeny, immediately followed by the virus-production…”
Get full text

A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract by Quirouette, Christian, Younis, Nada P, Reddy, Micaela B, Beauchemin, Catherine A A

“…Within the human respiratory tract (HRT), virus diffuses through the periciliary fluid (PCF) bathing the epithelium. But virus also undergoes advection: as the…”
Get full text

Agent-based modeling of host–pathogen systems: The successes and challenges by Bauer, Amy L., Beauchemin, Catherine A.A., Perelson, Alan S.

“…Agent-based models have been employed to describe numerous processes in immunology. Simulations based on these types of models have been used to enhance our…”
Get full text

Utility of Human In Vitro Data in Risk Assessments of Influenza A Virus Using the Ferret Model by Creager, Hannah M, Kieran, Troy J, Zeng, Hui, Sun, Xiangjie, Pulit-Penaloza, Joanna A, Holmes, Katie E, Johnson, Anders F, Tumpey, Terrence M, Maines, Taronna R, Beauchemin, Catherine A A, Belser, Jessica A

“…As influenza A viruses (IAV) continue to cross species barriers and cause human infection, the establishment of risk assessment rubrics has improved pandemic…”
Get full text

The Maximum Energy of Shock-accelerated Electrons in a Microturbulent Magnetic Field by Warren, Donald C., Beauchemin, Catherine A. A., Barkov, Maxim V., Nagataki, Shigehiro

“…Abstract Relativistic shocks propagating into a medium with low magnetization are generated and sustained by small-scale but very strong magnetic field…”
Get full text

Modelling the emergence of influenza drug resistance: The roles of surface proteins, the immune response and antiviral mechanisms by Dobrovolny, Hana M, Beauchemin, Catherine A A

“…The emergence of influenza drug resistance has become of particular interest as current planning for an influenza pandemic involves using massive amounts of…”
Get full text

Assessing mathematical models of influenza infections using features of the immune response by Dobrovolny, Hana M, Reddy, Micaela B, Kamal, Mohamed A, Rayner, Craig R, Beauchemin, Catherine A A

“…The role of the host immune response in determining the severity and duration of an influenza infection is still unclear. In order to identify severity factors…”
Get full text

Time to revisit the endpoint dilution assay and to replace the TCID50 as a measure of a virus sample's infection concentration by Cresta, Daniel, Warren, Donald C, Quirouette, Christian, Smith, Amanda P, Lane, Lindey C, Smith, Amber M, Beauchemin, Catherine A A

“…The endpoint dilution assay's output, the 50% infectious dose (ID50), is calculated using the Reed-Muench or Spearman-Kärber mathematical approximations, which…”
Get full text

The effect of random virus failure following cell entry on infection outcome and the success of antiviral therapy by Quirouette, Christian, Cresta, Daniel, Li, Jizhou, Wilkie, Kathleen P., Liang, Haozhao, Beauchemin, Catherine A. A.

“…A virus infection can be initiated with very few or even a single infectious virion, and as such can become extinct, i.e. stochastically fail to take hold or…”
Get full text

A method to determine the duration of the eclipse phase for in vitro infection with a highly pathogenic SHIV strain by Kakizoe, Yusuke, Nakaoka, Shinji, Beauchemin, Catherine A. A., Morita, Satoru, Mori, Hiromi, Igarashi, Tatsuhiko, Aihara, Kazuyuki, Miura, Tomoyuki, Iwami, Shingo

“…The time elapsed between successful cell infection and the start of virus production is called the eclipse phase. Its duration is specific to each virus strain…”
Get full text