Search Results - "Beau, Fabrice"

A Selective Matrix Metalloproteinase-12 Inhibitor Retards Atherosclerotic Plaque Development in Apolipoprotein E–Knockout Mice by Johnson, Jason L, Devel, Laurent, Czarny, Bertrand, George, Sarah J, Jackson, Christopher L, Rogakos, Vassilis, Beau, Fabrice, Yiotakis, Athanasios, Newby, Andrew C, Dive, Vincent

“…OBJECTIVE—Matrix metalloproteinase (MMP)-12 has been implicated in plaque progression and instability and is also amenable to selective inhibition. In this…”
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In Vivo Imaging of MMP‐13 Activity Using a Specific Polymer‐FRET Peptide Conjugate Detects Early Osteoarthritis and Inhibitor Efficacy by Duro‐Castano, Aroa, Lim, Ngee Han, Tranchant, Isabelle, Amoura, Mehdi, Beau, Fabrice, Wieland, Heike, Kingler, Otmar, Herrmann, Matthias, Nazaré, Marc, Plettenburg, Oliver, Dive, Vincent, Vicent, María J., Nagase, Hideaki

“…Imaging early molecular changes in osteoarthritic (OA) joints is instrumental for the development of disease‐modifying drugs. To this end, a fluorescent…”
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Third generation of matrix metalloprotease inhibitors: Gain in selectivity by targeting the depth of the S1′ cavity by Devel, Laurent, Czarny, Bertrand, Beau, Fabrice, Georgiadis, Dimitris, Stura, Enrico, Dive, Vincent

“…Following the disappointment of clinical trials with early broad-spectrum synthetic inhibitors of matrix metalloproteases (MMPs), the field is now resurging…”
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Biodistribution of Nanostructured Lipid Carriers in Mice Atherosclerotic Model by Devel, Laurent, Almer, Gunter, Cabella, Claudia, Beau, Fabrice, Bernes, Mylène, Oliva, Paolo, Navarro, Fabrice, Prassl, Ruth, Mangge, Harald, Texier, Isabelle

“…Atherosclerosis is a major cardiovascular disease worldwide, that could benefit from innovative nanomedicine imaging tools and treatments. In this perspective,…”
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Development of Selective Inhibitors and Substrate of Matrix Metalloproteinase-12 by Devel, Laurent, Rogakos, Vassilis, David, Arnaud, Makaritis, Anastasios, Beau, Fabrice, Cuniasse, Philippe, Yiotakis, Athanasios, Dive, Vincent

“…Four phosphinic peptide libraries with compounds having the general formula p-Br-Ph-(PO2-CH2)-Xaa′-Yaa′-Zaa′-NH2 have been prepared and screened against 10…”
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Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2 by Mores, Andreas, Matziari, Magdalini, Beau, Fabrice, Cuniasse, Philippe, Yiotakis, Athanasios, Dive, Vincent

“…Angiotensin-converting enzyme 2 (ACE2), a recently identified human homologue of angiotensin-converting enzyme, is a zinc metallocarboxypeptidase which may…”
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High throughput screening identifies disulfide isomerase DsbC as a very efficient partner for recombinant expression of small disulfide-rich proteins in E. coli by Nozach, Hervé, Fruchart-Gaillard, Carole, Fenaille, François, Beau, Fabrice, Ramos, Oscar Henrique Pereira, Douzi, Badreddine, Saez, Natalie J, Moutiez, Mireille, Servent, Denis, Gondry, Muriel, Thaï, Robert, Cuniasse, Philippe, Vincentelli, Renaud, Dive, Vincent

“…Disulfide-rich proteins or DRPs are versatile bioactive compounds that encompass a wide variety of pharmacological, therapeutic, and/or biotechnological…”
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Inhibitors of BMP‐1/tolloid‐like proteinases: efficacy, selectivity and cellular toxicity by Talantikite, Maya, Lécorché, Pascaline, Beau, Fabrice, Damour, Odile, Becker‐Pauly, Christoph, Ho, Wen‐Bin, Dive, Vincent, Vadon‐Le Goff, Sandrine, Moali, Catherine

“…BMP‐1/tolloid‐like proteinases belong to the astacin family of human metalloproteinases, together with meprins and ovastacin. They represent promising targets…”
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Grafting of functional motifs onto protein scaffolds identified by PDB screening – an efficient route to design optimizable protein binders by Tlatli, Rym, Nozach, Hervé, Collet, Guillaume, Beau, Fabrice, Vera, Laura, Stura, Enrico, Dive, Vincent, Cuniasse, Philippe

“…Artificial miniproteins that are able to target catalytic sites of matrix metalloproteinases (MMPs) were designed using a functional motif‐grafting approach…”
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Evaluation of P1'-Diversified Phosphinic Peptides Leads to the Development of Highly Selective Inhibitors of MMP-11 by Matziari, Magdalini, Beau, Fabrice, Cuniasse, Philippe, Dive, Vincent, Yiotakis, Athanasios

“…Phosphinic peptides were previously reported to be potent inhibitors of several matrixins (MMPs). To identify more selective inhibitors of MMP-11, a matrixin…”
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Detection of Matrix Metalloproteinase Active Forms in Complex Proteomes: Evaluation of Affinity versus Photoaffinity Capture by Bregant, Sarah, Huillet, Céline, Devel, Laurent, Dabert-Gay, Anne-Sophie, Beau, Fabrice, Thai, Robert, Czarny, Bertrand, Yiotakis, Athanasios, Dive, Vincent

“…Various attempts to detect matrix metalloproteinase (MMP) active forms from complex proteomes, based on the use of specific photoactivatable affinity probes,…”
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Molecular Determinants of Matrix Metalloproteinase-12 Covalent Modification by a Photoaffinity Probe by Dabert-Gay, Anne-Sophie, Czarny, Bertrand, Devel, Laurent, Beau, Fabrice, Lajeunesse, Evelyne, Bregant, Sarah, Thai, Robert, Yiotakis, Athanasios, Dive, Vincent

“…Mass spectroscopy, microsequencing, and site-directed mutagenesis studies have been performed to identify in human matrix metalloelastase (hMMP-12) residues…”
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Zinc–Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity by Rouanet-Mehouas, Cecile, Czarny, Bertrand, Beau, Fabrice, Cassar-Lajeunesse, Evelyne, Stura, Enrico A, Dive, Vincent, Devel, Laurent

“…The most exploited strategy to develop potent zinc–metalloprotease inhibitors relies on a core zinc chelator and a peptidic or nonpeptidic scaffold that…”
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Covalent labeling of Matrix Metalloproteases with affinity-based probes containing tuned reactive N-acyl-N-alkyl sulfonamide cleavable linkers by Devel, Laurent, Malgorn, Carole, Tohon, Regis-William, Launay, Marie, Patiniotis, Konstantinos, Sejalon-Cipolla, Mylène, Beau, Fabrice, Thai, Robert, Bruyat, Pierrick, Bonino, Annabelle, Bregant, Sarah, Subra, Gilles, Cantel, Sonia, Georgiadis, Dimitris

“…Original covalent probes with an N-acyl-N-alkyl sulfonamide cleavable linker were developed to target a broad set of human Matrix Metalloproteases (MMPs). The…”
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Covalent labeling of Matrix Metalloproteases with affinity‐based probes containing tuned reactive N‐acyl‐N‐alkyl sulfonamide cleavable linkers by Devel, Laurent, Malgorn, Carole, Tohon, Regis-William, Launay, Marie, Patiniotis, Konstantinos, Sejalon-Cipolla, Mylène, Beau, Fabrice, Thai, Robert, Bruyat, Pierrick, Bonino, Annabelle, Bregant, Sarah, Subra, Gilles, Cantel, Sonia, Georgiadis, Dimitris

“…Original covalent probes with an N‐acyl‐N‐alkyl sulfonamide cleavable linker were developed to target a broad set of human Matrix Metalloproteases (MMPs). The…”
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First evidence that emerging pinnatoxin-G, a contaminant of shellfish, reaches the brain and crosses the placental barrier by Servent, Denis, Malgorn, Carole, Bernes, Mylène, Gil, Sophie, Simasotchi, Christelle, Hérard, Anne-Sophie, Delzescaux, Thierry, Thai, Robert, Barbe, Peggy, Keck, Mathilde, Beau, Fabrice, Zakarian, Armen, Dive, Vincent, Molgó, Jordi

“…Massive proliferation of some toxic marine dinoflagellates is responsible for the occurrence of harmful algal blooms and the contamination of fish and…”
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Correlative radioimaging and mass spectrometry imaging: a powerful combination to study 14 C-graphene oxide in vivo biodistribution by Cazier, Hélène, Malgorn, Carole, Georgin, Dominique, Fresneau, Nathalie, Beau, Fabrice, Kostarelos, Kostas, Bussy, Cyrill, Campidelli, Stéphane, Pinault, Mathieu, Mayne-L'Hermite, Martine, Taran, Frédéric, Junot, Christophe, Fenaille, François, Sallustrau, Antoine, Colsch, Benoit

“…Research on graphene based nanomaterials has flourished in the last decade due their unique properties and emerging socio-economic impact. In the context of…”
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Monitoring In Vivo Performances of Protein–Drug Conjugates Using Site-Selective Dual Radiolabeling and Ex Vivo Digital Imaging by Cahuzac, Héloïse, Sallustrau, Antoine, Malgorn, Carole, Beau, Fabrice, Barbe, Peggy, Babin, Victor, Dubois, Steven, Palazzolo, Alberto, Thai, Robert, Correia, Isabelle, Lee, Ki Baek, Garcia-Argote, Sébastien, Lequin, Olivier, Keck, Mathilde, Nozach, Hervé, Feuillastre, Sophie, Ge, Xin, Pieters, Gregory, Audisio, Davide, Devel, Laurent

“…In preclinical models, the development and optimization of protein–drug conjugates require accurate determination of the plasma and tissue profiles of both the…”
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Ligand‐Directed Modification of Active Matrix Metalloproteases: Activity‐based Probes with no Photolabile Group by Kaminska, Monika, Bruyat, Pierrick, Malgorn, Carole, Doladilhe, Marion, Cassar‐Lajeunesse, Evelyne, Fruchart Gaillard, Carole, De Souza, Mélissa, Beau, Fabrice, Thai, Robert, Correia, Isabelle, Galat, Andrzej, Georgiadis, Dimitris, Lequin, Olivier, Dive, Vincent, Bregant, Sarah, Devel, Laurent

“…Activity‐based probes enable discrimination between the active enzyme and its inactive or inactivated counterparts. Since metalloproteases catalysis is…”
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Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease by Ciolek, Justyna, Reinfrank, Helen, Quinton, Loïc, Viengchareun, Say, Stura, Enrico A., Vera, Laura, Sigismeau, Sabrina, Mouillac, Bernard, Orcel, Hélène, Peigneur, Steve, Tytgat, Jan, Droctové, Laura, Beau, Fabrice, Nevoux, Jerome, Lombès, Marc, Mourier, Gilles, De Pauw, Edwin, Servent, Denis, Mendre, Christiane, Witzgall, Ralph, Gilles, Nicolas

“…Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and death in children and adults. Lowering cAMP in cystic tissues through…”
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