Search Results - "Beattie, Kylie A"

Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment by Dutta, Sara, Chang, Kelly C, Beattie, Kylie A, Sheng, Jiansong, Tran, Phu N, Wu, Wendy W, Wu, Min, Strauss, David G, Colatsky, Thomas, Li, Zhihua

“…Drug-induced Torsade-de-Pointes (TdP) has been responsible for the withdrawal of many drugs from the market and is therefore of major concern to global…”
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Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment by Chang, Kelly C, Dutta, Sara, Mirams, Gary R, Beattie, Kylie A, Sheng, Jiansong, Tran, Phu N, Wu, Min, Wu, Wendy W, Colatsky, Thomas, Strauss, David G, Li, Zhihua

“…The Comprehensive Proarrhythmia Assay (CiPA) is a global initiative intended to improve drug proarrhythmia risk assessment using a new paradigm of mechanistic…”
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Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19 by Delaunois, Annie, Abernathy, Matthew, Anderson, Warren D., Beattie, Kylie A., Chaudhary, Khuram W., Coulot, Julie, Gryshkova, Vitalina, Hebeisen, Simon, Holbrook, Mark, Kramer, James, Kuryshev, Yuri, Leishman, Derek, Lushbough, Isabel, Passini, Elisa, Redfern, Will S., Rodriguez, Blanca, Rossman, Eric I., Trovato, Cristian, Wu, Caiyun, Valentin, Jean‐Pierre

“…We applied a set of in silico and in vitro assays, compliant with the Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm, to assess the risk of…”
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A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity by Gall, Louis, Jardi, Ferran, Lammens, Lieve, Piñero, Janet, Souza, Terezinha M, Rodrigues, Daniela, Jennen, Danyel G J, de Kok, Theo M, Coyle, Luke, Chung, Seung-Wook, Ferreira, Sofia, Jo, Heeseung, Beattie, Kylie A, Kelly, Colette, Duckworth, Carrie A, Pritchard, D Mark, Pin, Carmen

“…We have built a quantitative systems toxicology modeling framework focused on the early prediction of oncotherapeutic-induced clinical intestinal adverse…”
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Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge by Beattie, Kylie A., Luscombe, Chris, Williams, Geoff, Munoz-Muriedas, Jordi, Gavaghan, David J., Cui, Yi, Mirams, Gary R.

“…Drugs that prolong the QT interval on the electrocardiogram present a major safety concern for pharmaceutical companies and regulatory agencies. Despite a…”
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Four Ways to Fit an Ion Channel Model by Clerx, Michael, Beattie, Kylie A., Gavaghan, David J., Mirams, Gary R.

“…Mathematical models of ionic currents are used to study the electrophysiology of the heart, brain, gut, and several other organs. Increasingly, these models…”
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Corrigendum: Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment by Dutta, Sara, Chang, Kelly C, Beattie, Kylie A, Sheng, Jiansong, Tran, Phu N, Wu, Wendy W, Wu, Min, Strauss, David G, Colatsky, Thomas, Li, Zhihua

“…[This corrects the article on p. 616 in vol. 8, PMID: 28878692.]…”
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Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence by Lei, Chon Lok, Clerx, Michael, Beattie, Kylie A., Melgari, Dario, Hancox, Jules C., Gavaghan, David J., Polonchuk, Liudmila, Wang, Ken, Mirams, Gary R.

“…Ion channel behavior can depend strongly on temperature, with faster kinetics at physiological temperatures leading to considerable changes in currents…”
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Considering discrepancy when calibrating a mechanistic electrophysiology model by Lei, Chon Lok, Ghosh, Sanmitra, Whittaker, Dominic G, Aboelkassem, Yasser, Beattie, Kylie A, Cantwell, Chris D, Delhaas, Tammo, Houston, Charles, Novaes, Gustavo Montes, Panfilov, Alexander V, Pathmanathan, Pras, Riabiz, Marina, Dos Santos, Rodrigo Weber, Walmsley, John, Worden, Keith, Mirams, Gary R, Wilkinson, Richard D

“…Uncertainty quantification (UQ) is a vital step in using mathematical models and simulations to take decisions. The field of cardiac simulation has begun to…”
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Prediction of inotropic effect based on calcium transients in human iPSC-derived cardiomyocytes and machine learning by Yang, Hongbin, Obrezanova, Olga, Pointon, Amy, Stebbeds, Will, Francis, Jo, Beattie, Kylie A., Clements, Peter, Harvey, James S., Smith, Graham F., Bender, Andreas

“…Functional changes to cardiomyocytes are undesirable during drug discovery and identifying the inotropic effects of compounds is hence necessary to decrease…”
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Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics by Beattie, Kylie A., Hill, Adam P., Bardenet, Rémi, Cui, Yi, Vandenberg, Jamie I., Gavaghan, David J., Boer, Teun P., Mirams, Gary R.

“…Key points Ion current kinetics are commonly represented by current–voltage relationships, time constant–voltage relationships and subsequently mathematical…”
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Endeavours made by trade associations, pharmaceutical companies and regulators in the replacement, reduction and refinement of animal experimentation in safety testing of pharmaceuticals by Harrell, Andrew W., Reid, Kirsty, Vahle, John, Brouta, Frederic, Beilmann, Mario, Young, Graeme, Beattie, Kylie A., Valentin, Jean Pierre, Shaid, Shajahan, Brinck, Peter

“…Following the European Commission decision to develop a roadmap to phase out animal testing and the signing of the US Modernisation Act, there is additional…”
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Reproducible model development in the cardiac electrophysiology Web Lab by Daly, Aidan C., Clerx, Michael, Beattie, Kylie A., Cooper, Jonathan, Gavaghan, David J., Mirams, Gary R.

“…The modelling of the electrophysiology of cardiac cells is one of the most mature areas of systems biology. This extended concentration of research effort…”
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Quantitative systems toxicology modeling in pharmaceutical research and development: An industry-wide survey and selected case study examples by Beattie, Kylie A, Verma, Meghna, Brennan, Richard J, Clausznitzer, Diana, Damian, Valeriu, Leishman, Derek, Spilker, Mary E, Boras, Britton, Li, Zhenhong, Oziolor, Elias, Rieger, Theodore R, Sher, Anna

“…Quantitative systems toxicology (QST) models are increasingly being applied for predicting and understanding toxicity liabilities in pharmaceutical research…”
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Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning by Yang, Hongbin, Stebbeds, Will, Francis, Jo, Pointon, Amy, Obrezanova, Olga, Beattie, Kylie A., Clements, Peter, Harvey, James S., Smith, Graham F., Bender, Andreas

“…Human induced pluripotent stem cell-derived cardiomyocytes have been established to detect dynamic calcium transients by fast kinetic fluorescence assays that…”
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Sinusoidal Voltage Protocols for Rapid Characterisation of Ion Channel Kinetics by Beattie, Kylie A., Hill, Adam P., Bardenet, Remi, Cui, Yi, Vandenberg, Jamie I., Gavaghan, David J., de Boer, Teun P., Mirams, Gary R.

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Considering discrepancy when calibrating a mechanistic electrophysiology model by Lei, Chon Lok, Ghosh, Sanmitra, G. Whittaker, Dominic, Aboelkassem, Yasser, Beattie, Kylie A., Cantwell, Chris D., Delhaas, Tammo, Houston, Charles, Novaes, Gustavo Montes, Panfilov, Alexander V., Pathmanathan, Pras, Riabiz, Marina, dos Santos, Rodrigo Weber, Walmsley, John, Worden, Keith, Mirams, Gary R., D. Wilkinson, Richard

“…Uncertainty quantification (UQ) is a vital step in using mathematical models and simulations to take decisions. The field of cardiac simulation has begun to…”
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Mathematical Modelling of hERG Channel Kinetics Using Sinusoidal Voltage Protocols by Beattie, Kylie A., Bardenet, Remi, Louttit, James B., Vandenberg, Jamie I., Hill, Adam P., Gavaghan, David J., de Boer, Teun P., Mirams, Gary R.

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Considering discrepancy when calibrating a mechanistic electrophysiology model by Lei, Chon Lok, Ghosh, Sanmitra, Whittaker, Dominic G, Aboelkassem, Yasser, Beattie, Kylie A, Cantwell, Chris D, Delhaas, Tammo, Houston, Charles, Novaes, Gustavo Montes, Panfilov, Alexander V, Pathmanathan, Pras, Riabiz, Marina, Santos, Rodrigo Weber dos, Walmsley, John, Worden, Keith, Mirams, Gary R, Wilkinson, Richard D

“…Phil. Trans. R. Soc. A. 378 (2020): 20190349 Uncertainty quantification (UQ) is a vital step in using mathematical models and simulations to take decisions…”
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