Search Results - "Beaton, Graham"

Targeting toll-like receptor-4 (TLR4)—an emerging therapeutic target for persistent pain states by Bruno, Kelly, Woller, Sarah A., Miller, Yury I., Yaksh, Tony L., Wallace, Mark, Beaton, Graham, Chakravarthy, Krishnan

“…Toll-like receptors (TLRs) are a family of pattern recognition receptors that initiate signaling in innate and adaptive immune pathways. The highly conserved…”
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Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain by Navia-Pelaez, Juliana M, Choi, Soo-Ho, Dos Santos Aggum Capettini, Luciano, Xia, Yining, Gonen, Ayelet, Agatisa-Boyle, Colin, Delay, Lauriane, Gonçalves Dos Santos, Gilson, Catroli, Glaucilene F, Kim, Jungsu, Lu, Jenny W, Saylor, Benjamin, Winkels, Holger, Durant, Christopher P, Ghosheh, Yanal, Beaton, Graham, Ley, Klaus, Kufareva, Irina, Corr, Maripat, Yaksh, Tony L, Miller, Yury I

“…Neuroinflammation is a major component in the transition to and perpetuation of neuropathic pain states. Spinal neuroinflammation involves activation of TLR4,…”
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Characterization of Novel Selective H1-Antihistamines for Clinical Evaluation in the Treatment of Insomnia by Moree, Wilna J, Li, Bin-Feng, Jovic, Florence, Coon, Timothy, Yu, Jinghua, Gross, Raymond S, Tucci, Fabio, Marinkovic, Dragan, Zamani-Kord, Said, Malany, Siobhan, Bradbury, Margaret J, Hernandez, Lisa M, O’Brien, Zhihong, Wen, Jianyun, Wang, Hua, Hoare, Samuel R. J, Petroski, Robert E, Sacaan, Aida, Madan, Ajay, Crowe, Paul D, Beaton, Graham

“…Analogues of the known H1-antihistamine R-dimethindene were profiled as potential agents for the treatment of insomnia. Several highly selective compounds were…”
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A pharmacokinetic evaluation of five H1 antagonists after an oral and intravenous microdose to human subjects by Madan, Ajay, O'Brien, Zhihong, Wen, Jianyun, O'Brien, Chris, Farber, Robert H., Beaton, Graham, Crowe, Paul, Oosterhuis, Berend, Garner, R. Colin, Lappin, Graham, Bozigian, Haig P.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Human microdosing studies with novel drug candidates offer an opportunity to evaluate their pharmacokinetic (PK)…”
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Selectivity profiling of novel indene H1-antihistamines for the treatment of insomnia by LI, Bin-Feng, MOREE, Wilna J, HOARE, Samuel R. J, PETROSKI, Robert E, MADAN, Ajay, CROWE, Paul D, BEATON, Graham, JINGHUA YU, COON, Timothy, ZAMANI-KORD, Said, MALANY, Siobhan, JALALI, Kayvon, JIANYUN WEN, HUA WANG, CHUN YANG

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Novel benzothiophene H1-antihistamines for the treatment of insomnia by MOREE, Wilna J, JOVIC, Florence, HERNANDEZ, Lisa M, O'BRIEN, Zhihong, JIANYUN WEN, HUA WANG, HOARE, Samuel R. J, PETROSKI, Robert E, SACAAN, Aida, MADAN, Ajay, CROWE, Paul D, BEATON, Graham, COON, Timothy, JINGHUA YU, LI, Bin-Feng, TUCCI, Fabio C, MARINKOVIC, Dragan, GROSS, Raymond S, MALANY, Siobhan, BRADBURY, Margaret J

“…SAR of lead benzothiophene H(1)-antihistamine 2 was explored to identify backup candidates with suitable pharmacokinetic profiles for an insomnia program…”
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Al2O3 anchored silver and gold nanoparticles as accessible, stable, and re-usable catalysts by Beaton, Graham, Zacks, Joshua, Stamplecoskie, Kevin

“…Nanoparticles of silver and gold have become widely researched as homogeneous catalysts for organic transformations. Silver systems have shown promising…”
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Surgical Pain Modeling with an Operant Orofacial Pain Assessment Device (OPAD) by Friedman, Craig D, Caudle, Robert, Beaton, Graham

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Tuning the Functionalization of Graphite for Hydrovoltaic Power Generation by Kumar, Rahul, Kay, George, Beaton, Graham, Liu, Guojun, Stamplecoskie, Kevin

“…The recent discovery of hydrovoltaic devices for power generation has led to a rapid growth into new materials for harvesting energy specifically for this…”
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Influence of pKₐ on the biotransformation of indene H₁-antihistamines by CYP2D6 by Huang, Charles, Moree, Wilna J, Zamani-Kord, Said, Li, Bin-Feng, Tucci, Fabio C, Malany, Siobhan, Wen, Jianyun, Wang, Hua, Hoare, Samuel R.J, Yang, Chun, Madan, Ajay, Crowe, Paul D, Beaton, Graham

“…Structure–activity relationship studies were conducted to reduce CYP2D6-mediated metabolism in a series of indene H₁-antihistamines. Reductions in pKₐ via…”
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Su1527 LYSOPHOSPHATIDIC ACID RECEPTOR 1 ANTAGONIST (EPGN2154) IMPROVES MURINE NASH by Bhattacharjee, Jashdeep, Beaton, Graham, Ravula, Satheesh, Lee, Suk Joong, Warren, Mikako, Tucci, Fabio, Kohli, Rohit

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Silver Nanoparticle on Alumina Films Tailored for Surface-enhanced Raman Spectroscopy and Detection of Pesticides by Beaton, Graham, Bdour, Yazan, Escobedo, Carlos, Stamplecoskie, Kevin

“…Silver nanoparticles (AgNPs) have been widely investigated for their ability to enable surface-enhanced Raman scattering for chemical sensing. Despite many…”
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Therapeutic efficacy of α7 ligands after acute ischaemic stroke is linked to conductive states of α7 nicotinic ACh receptors by Gaidhani, Nikhil, Tucci, Fabio C., Kem, William R., Beaton, Graham, Uteshev, Victor V.

“…Background and Purpose Targeting α7 nicotinic ACh receptors (nAChRs) in neuroinflammatory disorders including acute ischaemic stroke holds significant…”
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Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state by Woller, Sarah A, Ravula, Satheesh B, Tucci, Fabio C, Beaton, Graham, Corr, Maripat, Rivkah Isseroff, R, Soulika, Athena M, Chigbrow, Marianne, Eddinger, Kelly A, Yaksh, Tony L

“…Highlights • TAK-242 prevents LPS evoked TNF release from RAW267.4 cells and male and female macrophages. • IV, IT, and IP TAK-242 administration prevents…”
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Abstract 1174: CT179 degrades the olig2 transcription factor in glioblastoma stem-like cells and prolongs survival by Alton, Gordon R., Beaton, Graham, Knowles, Susan, Stein, Gregory, Kesari, Santosh

“…Abstract Olig2 is a bHLH transcription factor that has been shown to be a key driver of glioblastoma (GBM) tumorigenesis. Olig2 is expressed in human…”
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Drug-Eluting Embolic Loaded with Tyrosine Kinase Inhibitor Targeted Therapies for Transarterial Chemoembolization in a VX2 Model by Abi-Jaoudeh, Nadine, Sadeghi, Ben, Javan, Hanna, Na, Jim, Beaton, Graham, Tucci, Fabio, Ravula, Satheesh, Imagawa, David K

“…Drug-eluting embolic transarterial chemoembolization (DEE-TACE) improves the overall survival of hepatocellular carcinoma (HCC), but the agents used are not…”
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Reduced AIBP expression in bronchial epithelial cells of asthmatic patients: Potential therapeutic target by Miller, Marina, Pham, Alexa K., Gonen, Ayelet, Navia‐Pelaez, Juliana M., Xia, Katherine, Park, Sungwoo, Osterman, Andrei L., Bacon, Kevin, Beaton, Graham, Kurten, Richard C., Broide, David H., Miller, Yury I.

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Abstract 3030: CT179: A novel small molecule Olig2 inhibitor for the treatment of glioblastoma by Alton, Gordon, Beaton, Graham, Knowles, Susan, Stein, Greg, Mukthavaam, Rajesh, Kesari, Santosh

“…Abstract Glioblastoma (GBM) is an orphan disease with a high unmet medical need. Despite optimal treatment, the median survival is only 12 to 15 months in GBM…”
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Synthesis of phosphorodithioate DNA by the H-phosphonothioate method by Seeberger, Peter H., Caruthers, Marvin H., Bankaitis-Davis, Danute, Beaton, Graham

“…A novel method for the efficientsynthesis phosphorodithioate DNA using H-phosphonothioate synthons is described. The 5′-DMT-nucleoside H-phosphonothioate…”
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EXTH-18. CT-179 SELECTIVELY TARGETS OLIG2-POSITIVE GLIOMA STEM CELLS AND DEMONSTRATES POTENT ANTI-TUMOR ACTIVITY IN GLIOBLASTOMA by Alton, Gordon, Beaton, Graham, Knowles, Susan, Guerrero, Adriana, Kesari, Santosh, Stein, Gregory

“…Olig2 is a lineage-specific bHLH transcription factor in normal brain development and has been shown to be a critical oncogene controlling the tumorigenesis,…”
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