Search Results - "Beasley, Debbie"

Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3 by Qin, Zhexue, Bagley, Jessamyn, Sukhova, Galina, Baur, Wendy E, Park, Ho-Jin, Beasley, Debbie, Libby, Peter, Zhang, Yali, Galper, Jonas B

“…Abstract Abdominal Aortic Aneurysm (AAA) is a major cause of mortality and morbidity in men over 65 years of age. Male apolipoprotein E knockout (ApoE−/− )…”
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Role of Toll-Like Receptor 4 in Intimal Foam Cell Accumulation in Apolipoprotein E–Deficient Mice by Higashimori, Mie, Tatro, Jeffrey B, Moore, Kathryn J, Mendelsohn, Michael E, Galper, Jonas B, Beasley, Debbie

“…OBJECTIVE—Atherosclerosis encompasses a conspicuously maladaptive inflammatory response that might involve innate immunity. Here, we compared the role of…”
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γδT cells are prevalent in the proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice by Vu, Duc M, Tai, Albert, Tatro, Jeffrey B, Karas, Richard H, Huber, Brigitte T, Beasley, Debbie

“…Unique innate immunity-linked γδT cells have been seen in early human artery lesions, but their role in lesion development has received little attention. Here…”
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Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling by Yang, Xin, Coriolan, Daniel, Murthy, Vanishree, Schultz, Kelly, Golenbock, Douglas T, Beasley, Debbie

“…Recent evidence supports a role of Toll-like receptor (TLR) signaling in the development of atherosclerotic lesions. In this study, we tested whether TLR4…”
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Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells by Yang, Xin, Murthy, Vanishree, Schultz, Kelly, Tatro, Jeffrey B, Fitzgerald, Katherine A, Beasley, Debbie

“…Inflammation plays a key role in atherogenesis, perhaps promoted by bacterial and viral products present within the artery wall. Vascular smooth muscle cells…”
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Abstract 18255: Inhibition of Toll-Like Receptor 4 Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation: Role of STAT3 by Zhang, Yali, Park, Ho-Jin, Beasley, Debbie, Galper, Jonas

“…Abstract only Abdominal aortic aneurysm (AAA) is a potentially life-threatening degenerative vascular disease that affects 6-9% of men over 65. Toll-like…”
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Simvastatin Inhibits Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-Knockout Mice: Possible Role of ERK by YALI ZHANG, NAGGAR, Jack C, WELZIG, C. Michael, BEASLEY, Debbie, MOULTON, Karen S, PARK, Ho-Jin, GALPER, Jonas B

“…Abdominal aortic aneurysm (AAA) is a life-threatening disease affecting almost 10% of the population over age 65. Generation of AAAs by infusion of angiotensin…”
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Angiotensin II‐Induced TLR4 Mediated Abdominal Aortic Aneurysm formation in ApoE‐/‐ mice is Dependent on STAT3 by zhang, yali, Qin, Zhexue, Bagley, Jessamyn, Beasley, Debbie, Park, Ho‐Jin, Galper, Jonas

“…Abstract only…”
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Abstract 122: STAT3 Mediates Toll-Like Receptor 4--Dependent Abdominal Aortic Aneurysm Formation in Angiotensin II--Treated ApoE-/- Mice by Qin, Zhexue, Park, Ho-Jin, Beasley, Debbie, Galper, Jonas, Zhang, Yali

“…Abstract only Abdominal aortic aneurysm (AAAs) is a life threatening disease and currently the only treatment is surgical or endovascular repair. Using an…”
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Endogenous interleukin-1 alpha promotes a proliferative and proinflammatory phenotype in human vascular smooth muscle cells by Schultz, Kelly, Murthy, Vanishree, Tatro, Jeffrey B, Beasley, Debbie

“…During vascular disease and following injury, vascular smooth muscle cells (VSMC) proliferate and produce inflammation-promoting cytokines and chemokines…”
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Chlamydia pneumoniae and Chlamydial Heat Shock Protein 60 Stimulate Proliferation of Human Vascular Smooth Muscle Cells via Toll-Like Receptor 4 and p44/p42 Mitogen-Activated Protein Kinase Activation by Sasu, Sebastian, LaVerda, David, Qureshi, Nilofer, Golenbock, Douglas T, Beasley, Debbie

“…ABSTRACT—An early component of atherogenesis is abnormal vascular smooth muscle cell (VSMC) proliferation. The presence of Chlamydia pneumoniae in many…”
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Abstract 66: TLR2 Signaling Protects Against Angiotensin II--Mediated AAA Formation in ApoE -/- Mice by Zhang, Yali, Park, Ho-Jin, Bagley, Jessamyn, Maganto-Garcia, Elena, Kyriakis, John, Beasley, Debbie, Lichtman, Andrew, Galper, Jonas B

“…Abstract only Abdominal aortic aneurysm (AAA) is a potentially life-threatening degenerative vascular disease that affects 6-9% of men over 65. Although…”
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Role of Toll‐like receptor 4 in early intimal foam cell accumulation in apolipoprotein E‐deficient mice by Beasley, Debbie, Higashimori, Mie, Tatro, Jeffrey B, Moore, Kathryn J, Mendelsohn, Michael E, Galper, Jonas B

“…Atherosclerosis involves a maladaptive inflammatory response that might involve innate immunity. Here we compared the role of Toll‐like receptor 4 (TLR4) vs…”
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Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms by Schultz, Kelly, Murthy, Vanishree, Tatro, Jeffrey B, Beasley, Debbie

“…Arterial O(2) levels are thought to modulate vascular smooth muscle cell (VSMC) proliferation and vascular remodeling, but the mechanisms involved are poorly…”
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Prolyl hydroxylase‐2 promotes growth factor‐induced vascular smooth muscle cell proliferation by repressing HIF‐1α expression by Beasley, Debbie, Schultz, Kelly, Murthy, Vanishree

“…Low oxygen tension is thought to stimulate excessive proliferation of vascular smooth muscle cells (VSMC) that contributes to pulmonary hypertension, but the…”
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Pathogenic roles of Toll‐like receptor 2 and intracellular bacteria in intimal hyperplasia in apolipoprotein E‐deficient mice by Beasley, Debbie, Celestin, Flore, Moore, Kathryn, Mendelsohn, Michael

“…Abstract only Atherosclerosis is an inflammatory disease, and recent evidence suggests that innate immunity may contribute to the inflammatory process. We…”
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Toll-Like Receptor 2 Mediates Persistent Chemokine Release by Chlamydia pneumoniae–Infected Vascular Smooth Muscle Cells by Yang, Xin, Coriolan, Daniel, Schultz, Kelly, Golenbock, Douglas T, Beasley, Debbie

“…OBJECTIVE—The intracellular bacterium Chlamydia pneumoniae is present in many atherosclerotic lesions, where it could promote inflammation. This study…”
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Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells by Schultz, Kelly, Fanburg, Barry L, Beasley, Debbie

“…Hypoxia is thought to be a stimulus for the excessive proliferation of vascular smooth muscle cells (VSMC) that contributes to pulmonary hypertension, but the…”
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gamma delta T Cells Are Prevalent in the Proximal Aorta and Drive Nascent Atherosclerotic Lesion Progression and Neutrophilia in Hypercholesterolemic Mice: e109416 by Vu, Duc M, Tai, Albert, Tatro, Jeffrey B, Karas, Richard H, Huber, Brigitte T, Beasley, Debbie

“…Unique innate immunity-linked gamma delta T cells have been seen in early human artery lesions, but their role in lesion development has received little…”
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COX-2 and cytosolic PLA2 mediate IL-1beta-induced cAMP production in human vascular smooth muscle cells by Beasley, D

“…Interleukin (IL)-1 is a potent vasodilator that causes prolonged induction of prostacyclin (PGI2) and cAMP synthesis in human vascular smooth muscle cells…”
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