Search Results - "Bearrows, Shelby C"

Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules by Parchure, Anup, Tian, Meng, Stalder, Danièle, Boyer, Cierra K, Bearrows, Shelby C, Rohli, Kristen E, Zhang, Jianchao, Rivera-Molina, Felix, Ramazanov, Bulat R, Mahata, Sushil K, Wang, Yanzhuang, Stephens, Samuel B, Gershlick, David C, von Blume, Julia

“…Insulin is synthesized by pancreatic β-cells and stored into secretory granules (SGs). SGs fuse with the plasma membrane in response to a stimulus and deliver…”
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Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells by Bearrows, Shelby C, Bauchle, Casey J, Becker, McKenzie, Haldeman, Jonathan M, Swaminathan, Svetha, Stephens, Samuel B

“…Chromogranin B (CgB, also known as CHGB) is abundantly expressed in dense core secretory granules of multiple endocrine tissues and has been suggested to…”
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Potent Activity of an Anti-ICAM1 Antibody-Drug Conjugate against Multiple Myeloma by Sherbenou, Daniel W, Su, Yang, Behrens, Christopher R, Aftab, Blake T, Perez de Acha, Olivia, Murnane, Megan, Bearrows, Shelby C, Hann, Byron C, Wolf, Jeffery L, Martin, Thomas G, Liu, Bin

“…New therapies have changed the outlook for patients with multiple myeloma, but novel agents are needed for patients who are refractory or relapsed on currently…”
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Exploiting Protein Translation Dependence in Multiple Myeloma with Omacetaxine-Based Therapy by Walker, Zachary J, Idler, Beau M, Davis, Lorraine N, Stevens, Brett M, VanWyngarden, Michael J, Ohlstrom, Denis, Bearrows, Shelby C, Hammes, Andrew, Smith, Clayton A, Jordan, Craig T, Mark, Tomer M, Forsberg, Peter A, Sherbenou, Daniel W

“…The prognosis of patients with multiple myeloma who are resistant to proteasome inhibitors, immunomodulatory drugs (IMiD), and daratumumab is extremely poor…”
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ER Redox Homeostasis Regulates Proinsulin Trafficking and Insulin Granule Formation in the Pancreatic Islet β-Cell by Rohli, Kristen E, Boyer, Cierra K, Bearrows, Shelby C, Moyer, Marshall R, Elison, Weston S, Bauchle, Casey J, Blom, Sandra E, Zhang, Jianchao, Wang, Yanzhuang, Stephens, Samuel B

“…Defects in the pancreatic β-cell's secretion system are well-described in type 2 diabetes (T2D) and include impaired proinsulin processing and a deficit in…”
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Broad Efficacy of the Translation Inhibitor Omacetaxine in Relapsed/Refractory Multiple Myeloma Samples by Walker, Zachary J, Idler, Beau M, VanWyngarden, Michael J, Stevens, Brett M., Bearrows, Shelby C, Davis, Lorraine N, Hammes, Andrew, Smith, Clayton, Jordan, Craig T, Mark, Tomer M, Forsberg, Peter A, Sherbenou, Daniel W

“…Introduction: The prognosis of patients with multiple myeloma (MM) who are resistant to proteasome inhibitors (PIs) and immunomodulatory drugs (IMiDs) is…”
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