Search Results - "Bearoff, Frank"

Biased Signaling Agonists Promote Distinct Phosphorylation and Conformational States of the Dopamine D3 Receptor by Nepal, Binod, Barnett, Jessica, Bearoff, Frank, Kortagere, Sandhya

“…Biased agonists of G-protein-coupled receptors (GPCRs) have emerged as promising selective modulators of signaling pathways by offering therapeutic advantages…”
Get full text

Apigenin Modulates Dendritic Cell Activities and Curbs Inflammation Via RelB Inhibition in the Context of Neuroinflammatory Diseases by Ginwala, Rashida, Bhavsar, Raina, Moore, Patrick, Bernui, Mariana, Singh, Narendra, Bearoff, Frank, Nagarkatti, Mitzi, Khan, Zafar K., Jain, Pooja

“…Neuroinflammation leads to tissue injury causing many of the clinical symptoms of Multiple Sclerosis, an autoimmune disorder of the central nervous system…”
Get full text

Novel EAAT2 activators improve motor and cognitive impairment in a transgenic model of Huntington's disease by Bhatnagar, Akanksha, Parmar, Visha, Barbieri, Nicholas, Bearoff, Frank, Elefant, Felice, Kortagere, Sandhya

“…Glutamate excitotoxicity is causal in striatal neurodegeneration underlying motor dysfunction and cognitive deficits in Huntington's disease (HD). Excitatory…”
Get full text

Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease by Guillermo M. Alexander, Terry D. Heiman-Patterson, Frank Bearoff, Roger B. Sher, Laura Hennessy, Shannon Terek, Nicole Caccavo, Gregory A. Cox, Vivek M. Philip, Elizabeth A. Blankenhorn

“…Amyotrophic lateral sclerosis (ALS) is the most common degenerative motor neuron disorder. Although most cases of ALS are sporadic, 5–10% of cases are…”
Get full text

Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease by Alexander, Guillermo M, Heiman-Patterson, Terry D, Bearoff, Frank, Sher, Roger B, Hennessy, Laura, Terek, Shannon, Caccavo, Nicole, Cox, Gregory A, Philip, Vivek M, Blankenhorn, Elizabeth A

“…Amyotrophic lateral sclerosis (ALS) is the most common degenerative motor neuron disorder. Although most cases of ALS are sporadic, 5-10% of cases are…”
Get full text

Identification of genetic determinants of the sexual dimorphism in CNS autoimmunity by Bearoff, Frank, Case, Laure K, Krementsov, Dimitry N, Wall, Emma H, Saligrama, Naresha, Blankenhorn, Elizabeth P, Teuscher, Cory

“…Multiple sclerosis (MS) is a debilitating chronic inflammatory disease of the nervous system that affects approximately 2.3 million individuals worldwide, with…”
Get full text

Multiple roles of β‐Arrestin2 in initiating and sustaining D3R‐mediated ERK1/2 phosphorylation by G protein‐biased and unbiased D3R agonists by Xu, Wei, Bearoff, Frank, Kortagere, Sandhya

“…β‐arrestins play key roles in both terminating G protein signaling and activating G protein‐independent signaling across many G protein coupled receptors…”
Get full text

G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2 by Xu, Wei, Bearoff, Frank, Kortagere, Sandhya

“…Dopamine D3 receptors (D3R) have a causal role in neurological and psychiatric disorders. We have developed a novel class of G-protein biased (GPB) signaling…”
Get full text

Aggregated alpha-synuclein transcriptionally activates pro-inflammatory canonical and non-canonical NF-κB signaling pathways in peripheral monocytic cells by Bearoff, Frank, Dhavale, Dhruva, Kotzbauer, Paul, Kortagere, Sandhya

“…Parkinson’s disease (PD) is a neurodegenerative disorder characterized by chronic neuroinflammation, loss of dopaminergic neurons in the substantia nigra, and…”
Get full text

Aggregated Alpha‐Synuclein Activates Pro‐Inflammatory NFKB Signaling Pathways Through TLR‐Dependent and Independent Mechanisms in Peripheral Monocytic Cells by Bearoff, Frank, Dhavale, Dhruva, Kotzbauer, Paul, Kortagere, Sandhya

“…Toll‐like receptors (TLRs) are pattern recognition molecules that induce inflammatory signaling cascades upon recognition of pathogen or damage associated…”
Get full text

PEGylation enables subcutaneously administered nanoparticles to induce antigen-specific immune tolerance by Li, Peter Y., Bearoff, Frank, Zhu, Pu, Fan, Zhiyuan, Zhu, Yucheng, Fan, Mingyue, Cort, Laura, Kambayashi, Taku, Blankenhorn, Elizabeth P., Cheng, Hao

“…The development of nanomaterials to induce antigen-specific immune tolerance has shown promise for treating autoimmune diseases. While PEGylation has been…”
Get full text

Peripheral Inflammation Drives TLR2 and IL‐1R1 Mediated Neurodegeneration in Parkinson’s Disease by Bearoff, Frank, Johnson, Marguerite, Dhavale, Dhruva, Nonnemacher, Michael, Kotzbauer, Paul, Kortagere, Sandhya

“…Abstract only…”
Get full text

Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes by Aydemir, Özkan, Noble, Janelle A, Bailey, Jeffrey A, Lernmark, Åke, Marsh, Patrick, Andersson Svärd, Agnes, Bearoff, Frank, Blankenhorn, Elizabeth P, Mordes, John P

“…Type 1 diabetes (T1D) involves the interaction of multiple gene variants, environmental factors, and immunoregulatory dysfunction. Major T1D genetic risk loci…”
Get full text

Identification of Genetic Determinants of the Sexual Dimorphism in CNS Autoimmunity: e0117993 by Bearoff, Frank, Case, Laure K, Krementsov, Dimitry N, Wall, Emma H, Saligrama, Naresha, Blankenhorn, Elizabeth P, Teuscher, Cory

“…Multiple sclerosis (MS) is a debilitating chronic inflammatory disease of the nervous system that affects approximately 2.3 million individuals worldwide, with…”
Get full text

Exposure of coelomocytes from the earthworm Eisenia hortensis to Cu, Cd, and dimethylbenz[a]anthracene: An in vitro study examining reactive oxygen species production and immune response inhibition by Fuller-Espie, Sheryl L., Bearoff, Frank M., Minutillo, Madeleine A.

“…The principal aims of this study were to investigate the in vitro effects of copper (Cu), cadmium (Cd) and the polycyclic aromatic hydrocarbon (PAH)…”
Get full text

Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity by Bearoff, F, del Rio, R, Case, L K, Dragon, J A, Nguyen-Vu, T, Lin, C-Y, Blankenhorn, E P, Teuscher, C, Krementsov, D N

“…Regulation of gene expression in immune cells is known to be under genetic control, and likely contributes to susceptibility to autoimmune diseases such as…”
Get full text

Genetic Mapping and Analysis of Disease Susceptibility in a Mouse Model of Multiple Sclerosis by Bearoff, Frank M

“…Multiple sclerosis (MS) is a debilitating chronic inflammatory disease of the nervous system that affects approximately 2.3 million individuals worldwide, and…”
Get full text