Search Results - "Bean, Jonathan C"
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Reversal of Behavioral Deficits and Synaptic Dysfunction in Mice Overexpressing Neuregulin 1
Published in Neuron (Cambridge, Mass.) (22-05-2013)“…Neuregulin 1 (Nrg1) is a susceptibility gene of schizophrenia, a disabling mental illness that affects 1% of the general population. Here, we show that ctoNrg1…”
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2
Lrp4 in astrocytes modulates glutamatergic transmission
Published in Nature neuroscience (01-08-2016)“…Neurotransmission is regulated by glial cells; however, the underlying mechanisms are not fully understood. Sun and colleagues provide evidence that Lrp4 in…”
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Genetic labeling reveals novel cellular targets of schizophrenia susceptibility gene: distribution of GABA and non-GABA ErbB4-positive cells in adult mouse brain
Published in The Journal of neuroscience (01-10-2014)“…Neuregulin 1 (NRG1) and its receptor ErbB4 are schizophrenia risk genes. NRG1-ErbB4 signaling plays a critical role in neural development and regulates…”
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Maintenance of GABAergic Activity by Neuregulin 1-ErbB4 in Amygdala for Fear Memory
Published in Neuron (Cambridge, Mass.) (19-11-2014)“…Inhibitory neurotransmission in amygdala is important for fear learning and memory. However, mechanisms that control the inhibitory activity in amygdala are…”
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Anoctamin 4 channel currents activate glucose-inhibited neurons in the mouse ventromedial hypothalamus during hypoglycemia
Published in The Journal of clinical investigation (01-07-2023)“…Although glucose is the basic fuel essential to maintain the viability and functions of all cells, some neurons, namely glucose-inhibited (GI) neurons,…”
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Intermittent hypoxia promotes hippocampal neurogenesis and produces antidepressant-like effects in adult rats
Published in The Journal of neuroscience (22-09-2010)“…Increasing evidence indicates that stimulating hippocampal neurogenesis could provide novel avenues for the treatment of depression, and recent studies have…”
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Correction: Temporal and spatially controlled APP transgene expression using Cre-dependent alleles
Published in Disease models & mechanisms (01-03-2023)Get full text
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Regulation of spine formation by ErbB4 in PV-positive interneurons
Published in The Journal of neuroscience (04-12-2013)“…The trophic factor neuregulin 1 (Nrg1) and its receptor ErbB4 are schizophrenia candidate genes. NRG1-ErbB4 signaling was thought to regulate spine formation…”
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Temporal and spatially controlled APP transgene expression using Cre-dependent alleles
Published in Disease models & mechanisms (01-05-2022)“…Although a large number of mouse models have been made to study Alzheimer's disease, only a handful allow experimental control over the location or timing of…”
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10
SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis
Published in Cell & bioscience (09-10-2022)“…Pro-opiomelanocortin (POMC) neurons play a sexually dimorphic role in body weight and glucose balance. However, the mechanisms for the sex differences in POMC…”
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Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance
Published in Frontiers in endocrinology (Lausanne) (31-08-2022)“…Pro-opiomelanocortin (POMC) neurons are important for the regulation of body weight and glucose balance. The inhibitory tone to POMC neurons is mediated…”
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ERBB3-mediated regulation of Bergmann glia proliferation in cerebellar lamination
Published in Development (Cambridge) (01-02-2015)“…Cortical lamination is crucial for the assembly of cerebellar circuitry. In this process, granule neurons (GNs) migrate along Bergmann glia (BG), which are…”
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13
Reversal of Behavioral Deficits and Synaptic Dysfunction in Mice Overexpressing Neuregulin 1
Published in Neuron (Cambridge, Mass.) (19-06-2013)Get full text
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14
Early-Derived Murine Macrophages Temporarily Renounce Tissue Identity during Acute Systemic Inflammation
Published in The Journal of immunology (1950) (15-07-2021)“…In mice, a subset of cardiac macrophages and Kupffer cells derive from fetal precursors, seed the developing tissues, self-renew locally, and persist into…”
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RiboTag: Ribosomal Tagging Strategy to Analyze Cell-Type-Specific mRNA Expression In Vivo
Published in Current protocols in neuroscience (01-06-2019)“…Ribosome tagging has become a very useful in vivo approach for analyzing gene expression and mRNA translation in specific cell types that are difficult and…”
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Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation
Published in BMC neuroscience (08-09-2009)“…Caspase-independent apoptotic pathways are suggested as a mechanism for the delayed neuronal death following ischemic insult. However, the underlying…”
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Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior
Published in Nature medicine (01-12-2022)“…Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor…”
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Free-floating Immunostaining of Mouse Brains
Published in Journal of visualized experiments (07-10-2021)“…Immunohistochemical staining of mouse brains is a routine technique commonly used in neuroscience to investigate central mechanisms underlying the regulation…”
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Maintenance of GABAergic Activity by Neuregulin 1-ErbB4 in Amygdala for Fear Memory
Published in Neuron (Cambridge, Mass.) (17-05-2023)Get full text
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Loss of transient receptor potential channel 5 causes obesity and postpartum depression
Published in Cell (08-08-2024)“…Hypothalamic neural circuits regulate instinctive behaviors such as food seeking, the fight/flight response, socialization, and maternal care. Here, we…”
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