Search Results - "Beamish, Jeffrey A"
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Molecular regulation of contractile smooth muscle cell phenotype: implications for vascular tissue engineering
Published in Tissue engineering. Part B, Reviews (01-10-2010)“…The molecular regulation of smooth muscle cell (SMC) behavior is reviewed, with particular emphasis on stimuli that promote the contractile phenotype. SMCs can…”
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Engineered extracellular matrices with controlled mechanics modulate renal proximal tubular cell epithelialization
Published in PloS one (17-07-2017)“…Acute kidney injury (AKI) is common and associated with significant morbidity and mortality. Recovery from many forms of AKI involves the proliferation of…”
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Cell-mediated matrix stiffening accompanies capillary morphogenesis in ultra-soft amorphous hydrogels
Published in Biomaterials (01-02-2020)“…There is a critical need for biomaterials that support robust neovascularization for a wide-range of clinical applications. Here we report how cells alter…”
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Sustained alterations in proximal tubule gene expression in primary culture associate with HNF4A loss
Published in Scientific reports (02-10-2024)“…Primary cultures of proximal tubule cells are widely used to model the behavior of kidney epithelial cells in vitro. However, de-differentiation of primary…”
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High-throughput image analysis with deep learning captures heterogeneity and spatial relationships after kidney injury
Published in Scientific reports (19-04-2023)“…Recovery from acute kidney injury can vary widely in patients and in animal models. Immunofluorescence staining can provide spatial information about…”
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The effects of heparin releasing hydrogels on vascular smooth muscle cell phenotype
Published in Biomaterials (01-10-2009)“…Abstract Poly(ethylene glycol) diacrylate (PEGDA) hydrogel scaffolds were engineered to promote contractile smooth muscle cell (SMC) phenotype via controlled…”
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Gene regulation in regeneration after acute kidney injury
Published in The Journal of biological chemistry (01-08-2024)“…Acute kidney injury (AKI) is a common condition associated with significant morbidity, mortality, and cost. Injured kidney tissue can regenerate after many…”
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The influence of RGD-bearing hydrogels on the re-expression of contractile vascular smooth muscle cell phenotype
Published in Biomaterials (01-09-2009)“…Abstract This study reports on the ability of poly(ethylene glycol) diacrylate (PEGDA) hydrogel scaffolds with pendant integrin-binding GRGDSP peptides…”
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DNA Array-Based Transcriptional Analysis of Asporogenous, Nonsolventogenic Clostridium acetobutylicum Strains SKO1 and M5
Published in Journal of Bacteriology (01-08-2003)“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Renal-specific loss of ferroportin disrupts iron homeostasis and attenuates recovery from acute kidney injury
Published in American journal of physiology. Renal physiology (01-02-2024)“…Chronic kidney disease is increasing at an alarming rate and correlates with the increase in diabetes, obesity, and hypertension that disproportionately impact…”
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Pre‐cultured, cell‐encapsulating fibrin microbeads for the vascularization of ischemic tissues
Published in Journal of biomedical materials research. Part A (01-04-2024)“…There is a significant clinical need to develop effective vascularization strategies for tissue engineering and the treatment of ischemic pathologies. In…”
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Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease
Published in Kidney international (01-02-2024)“…Acute kidney injury (AKI) is a common condition that lacks effective treatments. In part, this shortcoming is due to an incomplete understanding of the genetic…”
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Deciphering the relative roles of matrix metalloproteinase‐ and plasmin‐mediated matrix degradation during capillary morphogenesis using engineered hydrogels
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01-11-2019)“…Extracellular matrix (ECM) remodeling is essential for the process of capillary morphogenesis. Here we employed synthetic poly(ethylene glycol) (PEG) hydrogels…”
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The effects of monoacrylated poly(ethylene glycol) on the properties of poly(ethylene glycol) diacrylate hydrogels used for tissue engineering
Published in Journal of biomedical materials research. Part A (01-02-2010)“…This study investigated the effects of poly(ethylene glycol) monoacrylate (PEGMA) on the properties of poly(ethylene glycol) diacrylate (PEGDA)‐co‐PEGMA…”
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Injectable pre-cultured tissue modules catalyze the formation of extensive functional microvasculature in vivo
Published in Scientific reports (23-09-2020)“…Revascularization of ischemic tissues is a major barrier to restoring tissue function in many pathologies. Delivery of pro-angiogenic factors has shown some…”
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Extracellular Matrix-like Cell-Adhesive Hydrogels from RGD-Containing Poly(ethylene glycol) Diacrylate
Published in Macromolecules (21-02-2006)Get full text
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Mouse Model of Local Iron Homeostasis Disruption in AKI: TH-PO106
Published in Journal of the American Society of Nephrology (01-11-2023)Get full text
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Loss of Pax2 and Pax8 in Proximal Tubules Protects Against Failed Repair After Ischemic AKI: SA-PO090
Published in Journal of the American Society of Nephrology (01-11-2022)Get full text
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Loss of Pax2 and Pax8 Induces Resistance to Ischemia in S3 Proximal Tubule: FR-PO183
Published in Journal of the American Society of Nephrology (01-11-2023)Get full text
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