Aspergillus infections in bone marrow transplant recipients

Aspergillus infections in bone marrow transplant recipients

Aspergillus infection was studied in patients admitted to the Bone Marrow Transplant (BMT) Service at the Johns Hopkins Oncology Center during a 9-year period. The overall incidence was 4% in 549 patients reviewed. The incidence at autopsy was 12% (21 of 174 patients autopsied). There was no differe...

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Bibliographic Details
Published in:Bone marrow transplantation (Basingstoke) Vol. 2; no. 2; p. 175
Main Authors: Wingard, J R, Beals, S U, Santos, G W, Merz, W G, Saral, R
Format: Journal Article
Language:English
Published: England 01-08-1987
Subjects:
Aspergillosis - epidemiology
Aspergillosis - etiology
Aspergillosis - pathology
Baltimore
Bone Marrow Transplantation
Humans
Opportunistic Infections - epidemiology
Opportunistic Infections - pathology
Baltimore
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Summary:Aspergillus infection was studied in patients admitted to the Bone Marrow Transplant (BMT) Service at the Johns Hopkins Oncology Center during a 9-year period. The overall incidence was 4% in 549 patients reviewed. The incidence at autopsy was 12% (21 of 174 patients autopsied). There was no difference in frequency of occurrence in allogeneic compared to autologous BMT recipients. However, all infections in autologous BMT patients (5 of 5) occurred during neutropenia before engraftment. In contrast, 16 of 17 infections in allogeneic BMT patients occurred after engraftment (p = 0.0002). This difference presumably related to differences in duration of neutropenia and immunodeficiency. Age, underlying disease, date of BMT, preparative regimen, remission status, prior treatment, interstitial pneumonitis and concomitant cytomegalovirus infection did not predispose patients to aspergillus infection. Different post-BMT immunosuppressive regimens did not affect the risk for aspergillus infection except that patients who were given cyclophosphamide plus methylprednisolone had a higher incidence of aspergillus infection than those given methotrexate (12% versus 1%, p = 0.03). Acute graft-versus-host disease imposed a slight risk for infection (p = 0.06).
ISSN:0268-3369