Vitamin D Insufficiency Is Associated With Diabetes Risk in Native American Children

Vitamin D Insufficiency Is Associated With Diabetes Risk in Native American Children

Aims/Hypothesis. Vitamin D insufficiency has not been well studied in Native American (NA) children, who are at risk for obesity and diabetes. The authors examined vitamin D insufficiency and its association with body mass index (BMI) and insulin resistance. Methods. In a cross-section of NA childre...

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Bibliographic Details
Published in:Clinical pediatrics Vol. 51; no. 2; pp. 146 - 153
Main Authors: Nsiah-Kumi, Phyllis A., Erickson, Judi M., Beals, Jennifer L., Ogle, Eric A., Whiting, Mary, Brushbreaker, Connie, Borgeson, Claudia D., Qiu, Fang, Yu, Fang, Larsen, Jennifer L.
Format: Journal Article
Language:English
Published: Los Angeles, CA SAGE Publications 01-02-2012
Westminster Publications, Inc
Subjects:
Adolescent
Biomarkers - blood
Child
Child, Preschool
Cross-Sectional Studies
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - etiology
Female
Humans
Indians, North American
Insulin
Insulin Resistance
Linear Models
Lipids
Lipids - blood
Male
Obesity
Prevalence
Risk Factors
South Dakota - epidemiology
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - diagnosis
Vitamin D Deficiency - ethnology
lipids
25-hydroxyvitamin D
type 2 diabetes prevention
vascular risk
25(OH) vitamin D
diabetes
insulin resistance
obesity
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Summary:Aims/Hypothesis. Vitamin D insufficiency has not been well studied in Native American (NA) children, who are at risk for obesity and diabetes. The authors examined vitamin D insufficiency and its association with body mass index (BMI) and insulin resistance. Methods. In a cross-section of NA children 5 to 18 years old (N = 198), anthropometrics, biomarkers of insulin resistance, and 25-hydroxy-vitamin D concentration [25(OH) vitamin D] were measured. BMI% and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. Results. Mean age was 10.8 ± 0.3 years (mean ± SEM). Mean serum 25(OH) vitamin D was 17.8 ± 0.4 ng/mL and 97% had vitamin D insufficiency [25(OH) vitamin D <30 ng/mL]. After adjusting for BMI, 25(OH) vitamin D was inversely associated with HOMA-IR (P < .0001) and several other markers of insulin resistance. Conclusions/Interpretation. Vitamin D insufficiency was nearly universal in this cohort of NA children and was associated with diabetes and vascular risk markers. Whether vitamin D supplementation can improve insulin resistance must be studied further.
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ISSN:0009-9228
1938-2707
DOI:10.1177/0009922811417290