Association of Two Opposing Responses Results in the Emergence of a Novel Conditioned Response

Association of Two Opposing Responses Results in the Emergence of a Novel Conditioned Response

Recent studies examining association of opposing responses, contrasting emotional valences, or counter motivational states have begun to elucidate how learning and memory processes can translate to clinical therapies for trauma or addiction. In the current study, association of opposing responses is...

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Bibliographic Details
Published in:Frontiers in behavioral neuroscience Vol. 16; p. 852266
Main Authors: Pribic, Micaela R, Black, Aristide H, Beale, Asia D, Gauvin, Jessica A, Chiang, Lisa N, Rose, Jacqueline K
Format: Journal Article
Language:English
Published: Switzerland Frontiers Research Foundation 29-04-2022
Frontiers Media S.A
Subjects:
Addictions
Anxiety
Behavior
Behavioral Neuroscience
C. elegans
classical conditioning
Conditioned response
delayed conditioning
Ecstasy
Investigations
Learning
Light
Locomotion
mechanosensory
Nematodes
Nervous system
Neurons
opposing responses
photosensory
Post traumatic stress disorder
Trauma
Worms
United States > US
opposing responses
C. elegans
photosensory
classical conditioning
delayed conditioning
mechanosensory
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Summary:Recent studies examining association of opposing responses, contrasting emotional valences, or counter motivational states have begun to elucidate how learning and memory processes can translate to clinical therapies for trauma or addiction. In the current study, association of opposing responses is tested in . Due to its relatively simple and well-described nervous system, it was hypothesized that association of two oppositional stimuli presented in a delayed conditioning protocol would strengthen the behavioral response to the first stimulus (alpha conditioning). To test this, were exposed to a tone vibration stimulus (to activate a mechanosensory-driven locomotor reversal response) paired with a blue light (to activate a forward locomotor response) at a 2-s delay. After five pairings, behavior was measured following a tone-alone stimulus. Worms that received stimulus pairing did not show an enhanced response to the first presented stimulus (tone vibration) but rather showed a marked increase in time spent in pause (cessation of movement), a new behavioral response (beta conditioning). This increase in pause behavior was accompanied by changes in measures of both backward and forward locomotion. Understanding the dynamics of conditioned behavior resulting from pairing of oppositional responses could provide further insight into how learning processes occur and may be applied.
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This article was submitted to Learning and Memory, a section of the journal Frontiers in Behavioral Neuroscience
Reviewed by: Yee Lian Chew, University of Wollongong, Australia; Eleni Gourgou, University of Michigan, United States
Edited by: Martin Giurfa, UMR 5169 Centre de Recherches sur la Cognition Animale (CRCA), France
These authors have contributed equally to this work
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2022.852266