Search Results - "Beadle, R."

Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524) by Lo, Michael K, Shrivastava-Ranjan, Punya, Chatterjee, Payel, Flint, Mike, Beadle, James R, Valiaeva, Nadejda, Murphy, Joyce, Schooley, Robert T, Hostetler, Karl Y, Montgomery, Joel M, Spiropoulou, Christina F

“…The necessity for intravenous administration of remdesivir confines its utility for treatment of coronavirus disease 2019 (COVID-19) to hospitalized patients…”
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Ether Lipid-Ester Prodrugs of Acyclic Nucleoside Phosphonates: Activity against Adenovirus Replication In Vitro by Hartline, Caroll B., Gustin, Kortney M., Wan, William B., Ciesla, Stephanie L., Beadle, James R., Hostetler, Karl Y., Kern, Earl R

“…The acyclic nucleoside phosphonate cidofovir (CDV) and its closely related analogue (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-adenine ([S]-HPMPA) have been…”
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Enhanced Inhibition of Orthopoxvirus Replication In Vitro by Alkoxyalkyl Esters of Cidofovir and Cyclic Cidofovir by KERN, Earl R, HARTLINE, Caroll, HARDEN, Emma, KEITH, Kathy, RODRIGUEZ, Natalie, BEADLE, James R, HOSTETLER, Karl Y

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Cardiac metabolism in hypertrophy and heart failure: implications for therapy by Siddiqi, N., Singh, S., Beadle, R., Dawson, D., Frenneaux, M.

“…The heart consumes huge amounts of energy to fulfil its function as a relentless pump. A highly sophisticated system of energy generation based on flexibility…”
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Oral Treatment of Cowpox and Vaccinia Virus Infections in Mice with Ether Lipid Esters of Cidofovir by Quenelle, Debra C, Collins, Deborah J, Wan, W Brad, Beadle, James R, Hostetler, Karl Y, Kern, Earl R

“…AUTHOR'S CORRECTION ( vol. 48 , p. 1919 ) Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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Alkoxyalkyl Esters of Cidofovir and Cyclic Cidofovir Exhibit Multiple-Log Enhancement of Antiviral Activity against Cytomegalovirus and Herpesvirus Replication In Vitro by BEADLE, James R, HARTLINE, Caroll, ALDERN, Kathy A, RODRIGUEZ, Natalie, HARDEN, Emma, KERN, Earl R, HOSTETLER, Karl Y

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Assessing heart disease using a novel magnetocardiography device by Beadle, R, McDonnell, D, Ghasemi-Roudsari, S, Unitt, L, Parker, S J, Varcoe, B T H

“…The aim of this paper is to present the use of a portable, unshielded magnetocardiograph (MCG) and identify key characteristics of MCG scans that could be used…”
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Insulin resistance in equine digital vessel rings: An in vitro model to study vascular dysfunction in equine laminitis by Venugopal, C.S, Eades, S, Holmes, E.P, Beadle, R.E

“…Reasons for performing study: One of the causes of equine laminitis is hyperinsulinaemia, which may be associated with endothelial dysfunction and insulin…”
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Octadecyloxyethyl Adefovir Exhibits Potent in vitro and in vivo Cytotoxic Activity and Has Synergistic Effects with Ara-C in Acute Myeloid Leukemia by Khoury, Haytham, He, Ruijuan, Schimmer, Aaron, Beadle, James R, Hostetler, Karl Y, Minden, Mark D

“…Acute myeloid leukemia (AML) continues to be a deadly disease, with only 50-70% of patients achieving complete remission and less than 30% of adults having…”
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Effect of potential therapeutic agents in reducing oxidative stress in pulmonary tissues of recurrent airway obstruction-affected and clinically healthy horses by VENUGOPAL, C., MARIAPPAN, N., HOLMES, E., KEARNEY, M., BEADLE, R.

“…Summary Reasons for performing study: To determine and compare the reactive oxygen and nitrogen species (ROS and RNS) in pulmonary tissues of horses affected…”
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Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]- Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections by PAINTER, George R, ALMOND, Merrick R, TROST, Lawrence C, LAMPERT, Bernhard M, NEYTS, Johan, DE CLERCQ, Erik, KORBA, Brent E, ALDERN, Kathy A, BEADLE, James R, HOSTETLER, Karl Y

“…ERRATUM ( vol. 51 , p. 4538 ) Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg…”
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Solution Structure of a DNA Duplex Containing the Potent Anti-Poxvirus Agent Cidofovir by Julien, Olivier, Beadle, James R, Magee, Wendy C, Chatterjee, Subhrangsu, Hostetler, Karl Y, Evans, David H, Sykes, Brian D

“…Cidofovir (1(S)-[3-hydroxy-2-(phosphonome-thoxy)propyl]cytosine, CDV) is a potent inhibitor of orthopoxvirus DNA replication. Prior studies have shown that,…”
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Comparative Activities of Lipid Esters of Cidofovir and Cyclic Cidofovir against Replication of Herpesviruses In Vitro by WILLIAMS-AZIZ, Stephanie L, HARTLINE, Caroll B, HARDEN, Emma A, DAILY, Shannon L, PRICHARD, Mark N, KUSHNER, Nicole L, BEADLE, James R, WAN, W. Brad, HOSTETLER, Karl Y, KERN, Earl R

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The Octadecyloxyethyl Ester of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy) Propyl]Adenine Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication in Genotype 1A, 1B, and 2A Replicons by WYLES, David L, KAIHARA, Kelly A, KORBA, Brent E, SCHOOLEY, Robert T, BEADLE, James R, HOSTETLER, Karl Y

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Temporal regulation of cytokine mRNA expression in equine recurrent airway obstruction by Horohov, D.W., Beadle, R.E., Mouch, S., Pourciau, S.S.

“…Acute and chronic inflammation of the airway remains an important health problem for equids. “Heaves” or recurrent airway obstruction (RAO) remains one of the…”
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A novel lipid prodrug strategy for sustained delivery of hexadecyloxypropyl 9-[2-(phosphonomethoxy)ethyl]guanine (HDP-PMEG) on unwanted ocular proliferation by Chen, Mei, Hou, Jiangping, Tan, Guilin, Xie, Peng, Freeman, William R., Beadle, James R., Hostetler, Karl Y., Cheng, Lingyun

“…Proliferative vitreoretinopathy (PVR) is a blinding eye disease and there is no effective pharmacological measure to prevent PVR development. The difficulty…”
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Oral Hexadecyloxypropyl-Cidofovir Therapy in Pregnant Guinea Pigs Improves Outcome in the Congenital Model of Cytomegalovirus Infection by BRAVO, Fernando J, BERNSTEIN, David I, BEADLE, James R, HOSTETLER, Karl Y, CARDIN, Rhonda D

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Long-term functional outcomes and academic-occupational status in implanted children after 10 to 14 years of cochlear implant use by Beadle, Elizabeth A R, McKinley, Dyan J, Nikolopoulos, Thomas P, Brough, Jackie, O'Donoghue, Gerard M, Archbold, Sue M

“…To assess a group of consecutively implanted children over 10 years after implantation with regard to implant device use and function, speech perception, and…”
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Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model by Buller, R.Mark, Owens, Gelita, Schriewer, Jill, Melman, Lora, Beadle, James R, Hostetler, Karl Y

“…Cidofovir (CDV) is a highly effective inhibitor of orthopoxvirus replication and may be used intravenously to treat smallpox or complications arising from the…”
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Inhibition of HIV-1 by Octadecyloxyethyl Esters of (S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl] Nucleosides and Evaluation of Their Mechanism of Action by Magee, Wendy C, Valiaeva, Nadejda, Beadle, James R, Richman, Douglas D, Hostetler, Karl Y, Evans, David H

“…(S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC [cidofovir]) and (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA) are potent inhibitors…”
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