Search Results - "Beach, T. G."

PIB is a non-specific imaging marker of amyloid-beta (Aβ) peptide-related cerebral amyloidosis by Lockhart, A., Lamb, J.R., Osredkar, T., Sue, L.I., Joyce, J.N., Ye, L., Libri, V., Leppert, D., Beach, T.G.

“…The in vivo imaging probe [11C]-PIB (Pittsburgh Compound B, N-methyl[11C]2-(4′-methylaminophenyl-6-hydroxybenzathiazole) is under evaluation as a key imaging…”
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Pathologic findings in prospectively ascertained essential tremor subjects by SHILL, H. A, ADLER, C. H, SABBAGH, M. N, CONNOR, D. J, CAVINESS, J. N, HENTZ, J. G, BEACH, T. G

“…To assess pathologic changes in prospectively characterized subjects with essential tremor (ET). Subjects enrolled in the Sun Health Research Institute Brain…”
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Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder by Boeve, B.F, Silber, M.H, Ferman, T.J, Lin, S.C, Benarroch, E.E, Schmeichel, A.M, Ahlskog, J.E, Caselli, R.J, Jacobson, S, Sabbagh, M, Adler, C, Woodruff, B, Beach, T.G, Iranzo, A, Gelpi, E, Santamaria, J, Tolosa, E, Singer, C, Mash, D.C, Luca, C, Arnulf, I, Duyckaerts, C, Schenck, C.H, Mahowald, M.W, Dauvilliers, Y, Graff-Radford, N.R, Wszolek, Z.K, Parisi, J.E, Dugger, B, Murray, M.E, Dickson, D.W

“…Abstract Objective To determine the pathologic substrates in patients with rapid eye movement (REM) sleep behavior disorder (RBD) with or without a coexisting…”
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TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers by FINCH, N, CARRASQUILLO, M. M, CROOK, J, FINGER, E, HANTANPAA, K. J, KARYDAS, A. M, SENGDY, P, GONZALEZ, J, SEELEY, W. W, JOHNSON, N, BEACH, T. G, MESULAM, M, BAKER, M, FORLONI, G, KERTESZ, A, KNOPMAN, D. S, UITTI, R, WHITE, C. L, CASELLI, R, LIPPA, C, BIGIO, E. H, WSZOLEK, Z. K, BINETTI, G, RUTHERFORD, N. J, MACKENZIE, I. R, MILLER, B. L, BOEVE, B. F, YOUNKIN, S. G, DICKSON, D. W, PETERSEN, R. C, GRAFF-RADFORD, N. R, GESCHWIND, D. H, RADEMAKERS, R, COPPOLA, G, DEJESUS-HERNANDEZ, M, CROOK, R, HUNTER, T, GHIDONI, R, BENUSSI, L

“…To determine whether TMEM106B single nucleotide polymorphisms (SNPs) are associated with frontotemporal lobar degeneration (FTLD) in patients with and without…”
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Inflammatory changes parallel the early stages of Alzheimer disease by Parachikova, A, Agadjanyan, M.G, Cribbs, D.H, Blurton-Jones, M, Perreau, V, Rogers, J, Beach, T.G, Cotman, C.W

“…Abstract Alzheimer disease (AD) is the most prominent cause of dementia in the elderly. To determine changes in the AD brain that may mediate the transition…”
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Differential spectral quantitative electroencephalography patterns between control and Parkinson's disease cohorts by Caviness, J. N., Utianski, R. L., Hentz, J. G., Beach, T. G., Dugger, B. N., Shill, H. A., Driver-Dunckley, E. D., Sabbagh, M. N., Mehta, S., Adler, C. H.

“…Background and purpose It is believed that progressive Lewy‐type synucleinopathy (LTS) is primarily responsible for the worsening of motor and non‐motor…”
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Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy by Beach, T.G., Woodhurst, W.B., MacDonald, D.B., Jones, M.W.

“…An immunoperoxidase method was used to demonstrate expression of HLA-DR (a Class II major histocompatibility antigen) as an indicator of microglial activation…”
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GBA mutations in Parkinson disease: earlier death but similar neuropathological features by Adler, C. H., Beach, T. G., Shill, H. A., Caviness, J. N., Driver‐Dunckley, E., Sabbagh, M. N., Patel, A., Sue, L. I., Serrano, G., Jacobson, S. A., Davis, K., Belden, C. M., Dugger, B. N., Paciga, S. A., Winslow, A. R., Hirst, W. D., Hentz, J. G.

“…Background and purpose Mutations in the glucocerebrosidase (GBA) gene are known to be a risk factor for Parkinson's disease (PD). Data on clinicopathological…”
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Cholinergic fibre loss associated with diffuse plaques in the non-demented elderly : The preclinical stage of Alzheimer's disease? by BEACH, T. G, HONER, W. G, HUGHES, L. H

“…Diffuse plaques are the earliest Alzheimer-type lesions in Down's syndrome and are a putative marker for the preclinical stage of Alzheimer's disease (AD). As…”
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The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease by Kuo, Y M, Beach, T G, Sue, L I, Scott, S, Layne, K J, Kokjohn, T A, Kalback, W M, Luehrs, D C, Vishnivetskaya, T A, Abramowski, D, Sturchler-Pierrat, C, Staufenbiel, M, Weller, R O, Roher, A E

“…High levels of A beta in the cerebral cortex distinguish demented Alzheimer's disease (AD) from nondemented elderly individuals, suggesting that decreased…”
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Functional, global and cognitive decline correlates to accumulation of Alzheimer's pathology in MCI and AD by Sabbagh, M N, Cooper, K, DeLange, J, Stoehr, J D, Thind, K, Lahti, T, Reisberg, B, Sue, L, Vedders, L, Fleming, S R, Beach, T G

“…Cognitive, global and functional instruments have been extensively investigated for correlations with neuropathological changes such as neurofibrillary tangles…”
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Cholinergic deafferentation of the rabbit cortex: a new animal model of Aβ deposition by Beach, Thomas G, Potter, Pamela E, Kuo, Yu-Min, Emmerling, Mark R, Durham, Robert A, Webster, Scott D, Walker, Douglas G, Sue, Lucia I, Scott, Sarah, Layne, Kathryn J, Roher, Alex E

“…Brain deposition of the amyloid β-peptide (Aβ) is a critical step in the pathogenesis of Alzheimer's disease (AD) and human cerebral amyloid angiopathy (CAA)…”
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Patterns of gliosis in Alzheimer's disease and aging cerebrum by Beach, T G, Walker, R, McGeer, E G

“…The distribution of astrocytic gliosis in Alzheimer's disease (AD) and aging cerebrum, as marked by immunoperoxidase staining for glial fibrillary acidic…”
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Expression of the proto-oncogene Ret, a component of the GDNF receptor complex, persists in human substantia nigra neurons in Parkinson's disease by Walker, Douglas G., Beach, Thomas G., Xu, Ren, Lile, Jack, Beck, Klaus D., McGeer, Edith G., L. McGeer, Patrick

“…The proto-oncogene Ret, a membrane-associated receptor protein tyrosine kinase, has recently been shown to be a component of the glial cell line-derived…”
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Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer’s Disease by Roher, Alex E, Esh, Chera, Kokjohn, Tyler A, Kalback, Walter, Luehrs, Dean C, Seward, James D, Sue, Lucia I, Beach, Thomas G

“…OBJECTIVES—We conducted a quantitative investigation of brain arterial atherosclerotic damage and its relationship to sporadic Alzheimer’s disease (AD)…”
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Involvement of Microglial Receptor for Advanced Glycation Endproducts (RAGE) in Alzheimer's Disease: Identification of a Cellular Activation Mechanism by Lue, Lih-Fen, Walker, Douglas G., Brachova, Libuse, Beach, Thomas G., Rogers, Joseph, Schmidt, Ann Marie, Stern, David M., Yan, Shi Du

“…Receptor-mediated interactions with amyloid β-peptide (Aβ) could be important in the evolution of the inflammatory processes and cellular dysfunction that are…”
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Senile plaques, amyloid β-protein, and acetylcholinesterase fibres : laminar distributions in alzheimer's disease striate cortex by BEACH, T. G, MCGEER, E. G

“…The laminar distributions of senile plaques and amyloid beta-protein (A beta P) within the striate cortex of patients with Alzheimer's disease (AD) were…”
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Lamina-specific arrangement of astrocytic gliosis and senile plaques in Alzheimer's disease visual cortex by Beach, T G, McGeer, E G

“…Alzheimer's disease (AD) visual cortex (area 17) was investigated using stains for plaques and tangles (Bielschowsky, thioflavine S) and gliosis (GFAP…”
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The distribution of substance P in the primate basal ganglia: an immunohistochemical study of baboon and human brain by Beach, T G, McGeer, E G

“…Using immunohistochemical methods we have studied the distribution of substance P fibers, terminals and perikarya throughout the basal ganglia of baboons and…”
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Calretinin-immunoreactive neurons in the human striatum by Parent, André, Cicchetti, Francesca, Beach, Thomas G.

“…The human striatum contains two types of neurons displaying immunoreactivity for the calcium-binding protein calretinin (CR): (1) large (22–44 μm), multipolar…”
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