Search Results - "Beach, L."

A multivariate analysis of the relationship between response and survival among patients with higher-risk myelodysplastic syndromes treated within azacitidine or conventional care regimens in the randomized AZA-001 trial by Gore, Steven D, Fenaux, Pierre, Santini, Valeria, Bennett, John M, Silverman, Lewis R, Seymour, John F, Hellström-Lindberg, Eva, Swern, Arlene S, Beach, Charles L, List, Alan F

“…The phase III AZA-001 study established that azacitidine significantly improves overall survival compared with conventional care regimens (hazard ratio 0.58…”
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Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study by Fenaux, Pierre, Prof, Mufti, Ghulam J, Prof, Hellstrom-Lindberg, Eva, Prof, Santini, Valeria, MD, Finelli, Carlo, MD, Giagounidis, Aristoteles, MD, Schoch, Robert, MD, Gattermann, Norbert, MD, Sanz, Guillermo, MD, List, Alan, Prof, Gore, Steven D, Prof, Seymour, John F, MBBS, Bennett, John M, Prof, Byrd, John, Prof, Backstrom, Jay, MD, Zimmerman, Linda, BSN, McKenzie, David, MS, Beach, CL, PharmD, Silverman, Lewis R, MD

“…Summary Background Drug treatments for patients with high-risk myelodysplastic syndromes provide no survival advantage. In this trial, we aimed to assess the…”
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Azacitidine Prolongs Overall Survival Compared With Conventional Care Regimens in Elderly Patients With Low Bone Marrow Blast Count Acute Myeloid Leukemia by FENAUX, Pierre, MUFTI, Ghulam J, DOMBRET, Hervé, BACKSTROM, Jay, ZIMMERMAN, Linda, MCKENZIE, David, BEACH, C. L, SILVERMAN, Lewis R, HELLSTROM-LINDBERG, Eva, SANTINI, Valeria, GATTERMANN, Norbert, GERMING, Ulrich, SANZ, Guillermo, LIST, Alan F, GORE, Steven, SEYMOUR, John F

“…In a phase III randomized trial, azacitidine significantly prolonged overall survival (OS) compared with conventional care regimens (CCRs) in patients with…”
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Outcome of High-Risk Myelodysplastic Syndrome After Azacitidine Treatment Failure by PREBET, Thomas, GORE, Steven D, QUESNEL, Bruno, BEACH, C. L, FENAUX, Pierre, VEY, Norbert, ESTERNI, Benjamin, GARDIN, Claude, ITZYKSON, Raphael, THEPOT, Sylvain, DREYFUS, François, RAUZY, Odile Beyne, RECHER, Christian, ADES, Lionel

“…Azacitidine (AZA) is the current standard of care for high-risk (ie, International Prognostic Scoring System high or intermediate 2) myelodysplastic syndrome…”
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Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine by Itzykson, Raphael, Thépot, Sylvain, Quesnel, Bruno, Dreyfus, Francois, Beyne-Rauzy, Odile, Turlure, Pascal, Vey, Norbert, Recher, Christian, Dartigeas, Caroline, Legros, Laurence, Delaunay, Jacques, Salanoubat, Célia, Visanica, Sorin, Stamatoullas, Aspasia, Isnard, Francoise, Marfaing-Koka, Anne, de Botton, Stephane, Chelghoum, Youcef, Taksin, Anne-Laure, Plantier, Isabelle, Ame, Shanti, Boehrer, Simone, Gardin, Claude, Beach, C.L., Adès, Lionel, Fenaux, Pierre

“…Prognostic factors for response and survival in higher-risk myelodysplastic syndrome patients treated with azacitidine (AZA) remain largely unknown. Two…”
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Oral Azacitidine Maintenance Therapy for Acute Myeloid Leukemia in First Remission by Wei, Andrew H, Döhner, Hartmut, Pocock, Christopher, Montesinos, Pau, Afanasyev, Boris, Dombret, Hervé, Ravandi, Farhad, Sayar, Hamid, Jang, Jun-Ho, Porkka, Kimmo, Selleslag, Dominik, Sandhu, Irwindeep, Turgut, Mehmet, Giai, Valentina, Ofran, Yishai, Kizil Çakar, Merih, Botelho de Sousa, Aida, Rybka, Justyna, Frairia, Chiara, Borin, Lorenza, Beltrami, Germana, Čermák, Jaroslav, Ossenkoppele, Gert J, La Torre, Ignazia, Skikne, Barry, Kumar, Keshava, Dong, Qian, Beach, C.L, Roboz, Gail J

“…Older patients with acute myeloid leukemia were treated with intensive chemotherapy and then randomly assigned to receive placebo or oral azacitidine (CC-486)…”
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Azacitidine improves clinical outcomes in older patients with acute myeloid leukaemia with myelodysplasia-related changes compared with conventional care regimens by Seymour, John F, Döhner, Hartmut, Butrym, Aleksandra, Wierzbowska, Agnieszka, Selleslag, Dominik, Jang, Jun Ho, Kumar, Rajat, Cavenagh, James, Schuh, Andre C, Candoni, Anna, Récher, Christian, Sandhu, Irwindeep, Del Castillo, Teresa Bernal, Al-Ali, Haifa Kathrin, Falantes, Jose, Stone, Richard M, Minden, Mark D, Weaver, Jerry, Songer, Steve, Beach, C L, Dombret, Hervé

“…Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes…”
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Transmission of Pathogenic Bacterial Organisms in the Anesthesia Work Area by LOFTUS, Randy W, KOFF, Matthew D, BURCHMAN, Corey C, SCHWARTZMAN, Joseph D, THORUM, Valerie, READ, Megan E, WOOD, Tammara A, BEACH, Michael L

“…The current prevalence of hospital-acquired infections and evolving amplification of bacterial resistance are major public health concerns. A heightened…”
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Further Analysis of Trials With Azacitidine in Patients With Myelodysplastic Syndrome: Studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B by SILVERMAN, Lewis R, MCKENZIE, David R, PETERSON, Bercedis L, HOLLAND, James F, BACKSTROM, Jay T, BEACH, C. L, LARSON, Richard A

“…Within the last two decades, a new understanding of the biology of myelodysplastic syndrome (MDS) has developed. With this understanding, new classification…”
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Randomized study of continuous high-dose lenalidomide, sequential azacitidine and lenalidomide, or azacitidine in persons 65 years and over with newly-diagnosed acute myeloid leukemia by Medeiros, Bruno C, McCaul, Kelly, Kambhampati, Suman, Pollyea, Daniel A, Kumar, Rajat, Silverman, Lewis R, Kew, Andrea, Saini, Lalit, Beach, C L, Vij, Ravi, Wang, Xiwei, Zhong, Jim, Gale, Robert Peter

“…Therapy of acute myeloid leukemia in older persons is associated with poor outcomes because of intolerance to intensive therapy, resistant disease and…”
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Masculinisation of the Zebra Finch Song System: Roles of Oestradiol and the Z-chromosome Gene Tubulin-Specific Chaperone Protein A by Beach, L. Q., Wade, J.

“…Robust sex differences in brain and behaviour exist in zebra finches. Only males sing, and forebrain song control regions are more developed in males. The…”
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In silico Comparison of Left Atrial Ablation Techniques That Target the Anatomical, Structural, and Electrical Substrates of Atrial Fibrillation by Roney, Caroline H, Beach, Marianne L, Mehta, Arihant M, Sim, Iain, Corrado, Cesare, Bendikas, Rokas, Solis-Lemus, Jose A, Razeghi, Orod, Whitaker, John, O'Neill, Louisa, Plank, Gernot, Vigmond, Edward, Williams, Steven E, O'Neill, Mark D, Niederer, Steven A

“…Catheter ablation therapy for persistent atrial fibrillation (AF) typically includes pulmonary vein isolation (PVI) and may include additional ablation lesions…”
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Multiple Reservoirs Contribute to Intraoperative Bacterial Transmission by Loftus, Randy W., Brown, Jeremiah R., Koff, Matthew D., Reddy, Sundara, Heard, Stephen O., Patel, Hetal M., Fernandez, Patrick G., Beach, Michael L., Corwin, Howard L., Jensen, Jens T., Kispert, David, Huysman, Bridget, Dodds, Thomas M., Ruoff, Kathryn L., Yeager, Mark P.

“…Intraoperative stopcock contamination is a frequent event associated with increased patient mortality. In the current study we examined the relative…”
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Hematologic Response to Three Alternative Dosing Schedules of Azacitidine in Patients With Myelodysplastic Syndromes by LYONS, Roger M, COSGRIFF, Thomas M, MODI, Sanjiv S, GERSH, Robert H, HAINSWORTH, John D, COHN, Allen L, MCINTYRE, Heidi J, FERNANDO, Indra J, BACKSTROM, Jay T, BEACH, C. L

“…Azacitidine (AZA) is effective treatment for myelodysplastic syndromes (MDS) at a dosing schedule of 75 mg/m(2)/d subcutaneously for 7 days every 4 weeks. The…”
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Intraoperative Ketamine Reduces Perioperative Opiate Consumption in Opiate-dependent Patients with Chronic Back Pain Undergoing Back Surgery by LOFTUS, Randy W, YEAGER, Mark P, CLARK, Jeffrey A, BROWN, Jeremiah R, ABDU, William A, SENGUPTA, Dilip K, BEACH, Michael L

“…Ketamine is an N-methyl-d-aspartate receptor antagonist that has been shown to be useful in the reduction of acute postoperative pain and analgesic consumption…”
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Effects of azacitidine compared with conventional care regimens in elderly (≥75 years) patients with higher-risk myelodysplastic syndromes by Seymour, John F, Fenaux, Pierre, Silverman, Lewis R, Mufti, Ghulam J, Hellström-Lindberg, Eva, Santini, Valeria, List, Alan F, Gore, Steven D, Backstrom, Jay, McKenzie, David, Beach, C.L

“…Abstract This analysis compared azacitidine (AZA) to conventional care regimens (CCR) and their associated overall survival (OS) and tolerability in the subset…”
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Exposure to Movie Smoking: Its Relation to Smoking Initiation Among US Adolescents by Sargent, James D, Beach, Michael L, Adachi-Mejia, Anna M, Gibson, Jennifer J, Titus-Ernstoff, Linda T, Carusi, Charles P, Swain, Susan D, Heatherton, Todd F, Dalton, Madeline A

“…Regional studies have linked exposure to movie smoking with adolescent smoking. We examined this association in a representative US sample. We conducted a…”
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Changing the paradigm for diagnostic MRI in pediatrics: Don't hold your breath by Masaracchia, Melissa M., Tsapakos, Michael J., McNulty, Nancy J., Beach, Michael L., Cravero, Joseph

“…Summary Increasingly complex pediatric patients and improvements in technology warrant reevaluation of the risk associated with anesthesia for diagnostic…”
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Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis by KORETH, John, PIDALA, Joseph, FENAUX, Pierre, JADERSTEN, Martin, HELLSTROM-LINDBERG, Eva, GALE, Robert Peter, BEACH, C. L, LEE, Stephanie J, HOROWITZ, Mary M, GREENBERG, Peter L, TALLMAN, Martin S, DIPERSIO, John F, PEREZ, Waleska S, BUNJES, Donald, WEISDORF, Daniel J, CUTLER, Corey, DEEG, H. Joachim, GARCIA-MANERO, Guillermo, MALCOVATI, Luca, CAZZOLA, Mario, PARK, Sophie, ITZYKSON, Raphael, ADES, Lionel

“…Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders that are more common in patients aged ≥ 60 years and are incurable with conventional…”
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Management of adverse events in patients with acute myeloid leukemia in remission receiving oral azacitidine: experience from the phase 3 randomized QUAZAR AML-001 trial by Ravandi, Farhad, Roboz, Gail J., Wei, Andrew H., Döhner, Hartmut, Pocock, Christopher, Selleslag, Dominik, Montesinos, Pau, Sayar, Hamid, Musso, Maurizio, Figuera-Alvarez, Angela, Safah, Hana, Tse, William, Sohn, Sang Kyun, Hiwase, Devendra, Chevassut, Timothy, Pierdomenico, Francesca, La Torre, Ignazia, Skikne, Barry, Bailey, Rochelle, Zhong, Jianhua, Beach, C. L., Dombret, Herve

“…Background Most older patients with acute myeloid leukemia (AML) who attain morphologic remission with intensive chemotherapy (IC) will eventually relapse and…”
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