Limulus amebocyte lysate test use in clinical diagnostic in children with infectious diseases--preliminary report

The aim of this preliminary study was (1) to evaluate the usefulness of the Limulus amebocyte lysate (LAL) test as a diagnostic tool in pediatric clinic, and (2) to examine the serum ET levels in hospitalized patients. Bacterial blood endotoxin (ET) was measured in 50 children with infections of dif...

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Bibliographic Details
Published in:	Polski merkuriusz lekarski Vol. 19; no. 110; p. 175
Main Authors:	Matuszewska, Elzbieta, Miks, Barbara, Grygalewicz, Jacek, Załtska-Ponganis, Joanna, Mordasewicz-Goliszewska, Maria, Bełzecka, Bozenna
Format:	Journal Article
Language:	Polish
Published:	Poland 01-08-2005
Subjects:	Animals Bacterial Infections - diagnosis Child Child, Preschool Endotoxins - blood Female Horseshoe Crabs - metabolism Humans Infant Limulus Test Male Predictive Value of Tests Sensitivity and Specificity
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Summary:	The aim of this preliminary study was (1) to evaluate the usefulness of the Limulus amebocyte lysate (LAL) test as a diagnostic tool in pediatric clinic, and (2) to examine the serum ET levels in hospitalized patients. Bacterial blood endotoxin (ET) was measured in 50 children with infections of different etiology and localization. A Limulus amebocyte lysate (LAL) test was used. The usefulness of LAL test in routine diagnostic procedures in hospitalized children with infections was not proven so far. However, the LAL test appeared useful in the urinary tract infection (UTI) cases in which significant elevation of serum ET levels were demonstrated. Moreover, it was confirmed that LAL test can be performed as well in serum: the mean values of serum ET levels in our patients were comparable with published ET plasma values in adults.
ISSN:	1426-9686