Search Results - "Bečeheli, Ivona"
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Antagonistic and synergistic epigenetic modulation using orthologous CRISPR/dCas9-based modular system
Published in Nucleic acids research (10-10-2019)“…Abstract Establishing causal relationship between epigenetic marks and gene transcription requires molecular tools, which can precisely modify specific genomic…”
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Serotonin system in the human placenta - the knowns and unknowns
Published in Frontiers in endocrinology (Lausanne) (01-12-2022)“…The biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT) is a chemical messenger widely distributed in the brain and various other organs. Its homeostasis…”
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Differential Serotonin Uptake Mechanisms at the Human Maternal-Fetal Interface
Published in International journal of molecular sciences (21-07-2021)“…Serotonin (5-HT) plays an extensive role during pregnancy in regulating both the placental physiology and embryonic/fetal development. The uptake of 5-HT into…”
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Genomics and epigenomics of the human glycome
Published in Glycoconjugate journal (2013)“…The majority of all proteins are glycosylated and glycans have numerous important structural, functional and regulatory roles in various physiological…”
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Glucose, Insulin and Oxygen Modulate Expression of Serotonin-Regulating Genes in Human First-Trimester Trophoblast Cell Line ACH-3P
Published in Biomedicines (01-06-2023)“…Serotonin signaling plays an important role in regulating development and functions of the placenta. We hypothesized that metabolic disturbances associated…”
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Methylation of serotonin regulating genes in cord blood cells: association with maternal metabolic parameters and correlation with methylation in peripheral blood cells during childhood and adolescence
Published in Clinical epigenetics (03-01-2024)“…Serotonin (5-hydroxytryptamine, 5-HT) signaling is involved in neurodevelopment, mood regulation, energy metabolism, and other physiological processes. DNA…”
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Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene ( HTR2A ) in the Human Placenta
Published in Biomedicines (17-02-2022)“…The serotonin receptor 2A gene ( ) is a strong candidate for the fetal programming of future behavior and metabolism. Maternal obesity and gestational diabetes…”
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Association Between RASSF1A Promoter Methylation and Testicular Germ Cell Tumor: A Meta-analysis and a Cohort Study
Published in Cancer genomics & proteomics (01-09-2017)“…The RAS association domain family protein 1a (RASSF1A) is a prominent tumor suppressor gene showing altered promoter methylation in testicular germ cell tumors…”
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Human-specific features and developmental dynamics of the brain N-glycome
Published in Science advances (08-12-2023)“…Comparative "omics" studies have revealed unique aspects of human neurobiology, yet an evolutionary perspective of the brain N-glycome is lacking. We performed…”
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Relationship between placental serotonin transporter gene (SLC6A4) expression, maternal metabolic state, and infant birthweight
Published in Placenta (Eastbourne) (01-05-2022)Get full text
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Glycans are a novel biomarker of chronological and biological ages
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01-07-2014)“…Fine structural details of glycans attached to the conserved N-glycosylation site significantly not only affect function of individual immunoglobulin G (IgG)…”
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