Search Results - "Bdzhola, V. G."

Activity of Nonnucleoside Inhibitors of O6-methylguanine-DNA Methyltransferase Repair Enzyme in Human Cells In Vitro by Zhuvaka, K. S., Volynets, G. P., Ruban, T. P., Nidoeva, Z. M., Iatsyshyna, A. P., Macewizc, L. L., Bdzhola, V. G., Yarmoluk, S. M., Lukash, L. L.

“…The repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) eliminates alkyl lesions that play the main anticancer role in alkylating chemotherapy. The…”
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Flavone inspired discovery of benzylidenebenzofuran-3(2H)-ones (aurones) as potent inhibitors of human protein kinase CK2 by Protopopov, M.V., Vdovin, V.S., Starosyla, S.A., Borysenko, I.P., Prykhod'ko, A.O., Lukashov, S.S., Bilokin, Y.V., Bdzhola, V.G., Yarmoluk, S.M.

“…[Display omitted] •New substituted benzylidenebenzofuran-3(2H)-ones were synthesized.•41 aurones inhibited CK2 with IC50 in nanomolar range of values.•The most…”
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Design, synthesis and biological evaluation of N-phenylthieno[2,3-d]pyrimidin-4-amines as inhibitors of FGFR1 by Gryshchenko, A.A., Bdzhola, V.G., Balanda, A.O., Briukhovetska, N.V., Kotey, I.M., Golub, A.G., Ruban, T.P., Lukash, L.L., Yarmoluk, S.M.

“…Protein kinase FGFR1 inhibitors: We report a series of N-phenylthieno[2,3-d]pyrimidin-4-amines as a novel class of nanomolar-range FGFR1 inhibitors. These new…”
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Design, synthesis and biological evaluation of 5-amino-4-(1H-benzoimidazol-2-yl)-phenyl-1,2-dihydro-pyrrol-3-ones as inhibitors of protein kinase FGFR1 by Gryshchenko, A.A., Tarnavskiy, S.S., Levchenko, K.V., Bdzhola, V.G., Volynets, G.P., Golub, A.G., Ruban, T.P., Vygranenko, K.V., Lukash, L.L., Yarmoluk, S.M.

“…[Display omitted] Fibroblast growth factor receptor 1 (FGFR1) plays an important role in tumorigenesis and is therefore an attractive target for anticancer…”
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Identification of novel protein kinase CK2 inhibitors among indazole derivatives by Vdovin, V. S., Lukashov, S. S., Borysenko, I. P., Borovykov, O. V., Protopopov, M. V., Bdzhola, V. G., Yarmoluk, S. M.

“…Aim. To synthesize the novel purine bioisosteres – indazole derivatives and evaluate inhibitory activity of these compounds towards CK2 in the in vitro system…”
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Evaluation of in vitro activity and SAR study of the novel hetarylamino-3-aryl-1H-indazole derivatives as inhibitors of protein kinase CK2 by Protopopov, M. V., Vdovin, V. S., Lukashov, S. S., Ostrynska, O. V., Borysenko, I. P., Borovykov, O. V., Starosyla, S. A., Bilokin, Y. V., Kukharenko, O. P., Bdzhola, V. G., Yarmoluk, S. M.

“…Aim. To identify novel protein kinase CK2 inhibitors among the 5-hetarylamino-1H-indazoles. Methods. Biochemical testing was carried out with the aid of γ-32P…”
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Identification of membrane proteins as potential drug targets in Escherichia coli ATCC 25922 using in silico approaches by Koleiev, I. M., Starosyla, S. A., Protopopov, M. V., Volynets, G. P., Sapelkin, V. M., Pletnova, L. V., Syniugin, A. R., Kachaput, N. O., Matiushok, V. I., Bdzhola, V. G., Yarmoluk, S. M.

“…Aim. To identify the novel potential drug targets of E.coli ATCC 25922 through subtractive genomic analysis. Methods. The identification of non-homologous…”
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The synthesis of 5-hetarylamino-3-aryl-1H-indazoles as inhibitors of protein kinase CK2 by Protopopov, M. V., Vdovin, V. S., Lukashov, S. S., Ostrynska, O. V., Borysenko, I. P., Borovykov, O. V., Starosyla, S. A., Bilokin, Y. V., Kukharenko, O. P., Bdzhola, V. G., Yarmoluk, S. M.

“…Aim. Basing of our earlier finding of inhibitory activity of 5-(4-quinazolylamino)-3-arylindazoles against human protein kinase CK2, the synthesis of nitrogen…”
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Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton by Kramerov, A. A., Golub, A. G., Bdzhola, V. G., Yarmoluk, S. M., Ahmed, K., Bretner, M., Ljubimov, A. V.

“…Ubiquitous protein kinase CK2 is a key regulator of cell migration, proliferation and tumor growth. CK2 is abundant in retinal astrocytes, and its inhibition…”
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Hit identification of FGFR1 inhibitors using receptor-based virtual screening by Tarnavskiy, S. S., Protopopov, M. V., Borovykov, O. V., Pryhodko, A. O., Bdzhola, V. G., Yarmoluk, S. M.

“…Aim. To identify novel FGFR1 inhibitors using the virtual screening approach. Methods. Virtual screening of a small organic compounds library was performed by…”
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Identification of 4‐methoxythieno[2,3‐d]pyrimidines as FGFR1 Inhibitors by Kotey, I. M., Protopopov, M. V., Starosyla, S. A., Balanda, A. O., Pletnova, L. V., Prykhod'ko, A. O., Bdzhola, V. G., Yarmoluk, S. M.

“…Aim. To identify novel FGFR1 inhibitors using virtual screening approach. Methods. We used methods of organic synthesis, molecular docking via the Autodock…”
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Evaluation of 4,5,6,7-tetrahalogeno-1H-isoindole-1,3(2H)-diones as inhibitors of human protein kinase CK2 by Golub, A G, Yakovenko, O Ya, Prykhod'ko, A O, Lukashov, S S, Bdzhola, V G, Yarmoluk, S M

“…Protein kinase CK2 (Casein Kinase 2) is an extremely pleiotropic Ser/Thr kinase with high constitutive activity. The observation of CK2 deregulations in…”
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Synthesis and biological evaluation of novel amino-substituted derivatives of pyrido[2,3-d]pyrimidine as inhibitors of protein kinase CK2 by Zinchenko, A. N., Muzychka, L. V., Smolii, O. B., Bdzhola, V. G., Protopopov, M. V., Yarmoluk, S. M.

“…Aim. A search for human protein kinase CK2 inhibitors in a series of new amino-substituted pyrido[2,3-d]pyrimidine derivatives. Methods. Organic synthesis,…”
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Search of protein kinase CK2 inhibitors based on purine-2,6-diones derivatives by M. V. Protopopov, O. V. Ostrynska, D. H. Ivanchenko, S. A. Starosyla, V. G. Bdzhola, M. I. Romanenko, S. M. Yarmoluk

“…This work is aimed to the search of protein kinase CK2 inhibitors among the purine-2,6-dione derivatives by molecular docking and biochemical tests. It was…”
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Hit identification of CK2 inhibitors by virtual screening by Protopopov, M. V., Starosyla, S. A., Borovykov, O. V., Sapelkin, V. N., Bilokin, Y. V., Bdzhola, V. G., Yarmoluk, S. M.

“…Aim. To search for new CK2 inhibitors by virtual screening. Methods. Virtual screening of a small organic compounds library was performed by molecular docking…”
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Rational design of protein kinase inhibitors by Yarmoluk, S. M., Nyporko, A. Yu, Bdzhola, V. G.

“…Modern methodological approaches to rational design of low molecular weight compounds with specific activity in relation to predetermined biomolecular targets…”
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Protein kinase ASK1 as potential therapeutic target by Volynets, G. P., Bdzhola, V. G., Kukharenko, O. P., Sovetova, O. V., Yarmoluk, S. M.

“…Apoptosis signal-regulating kinase 1 (ASK1) is serine/threonine kinase of kinase 5 that activates MAP-kinase (MAPKKK5). ASK1 induces apoptosis via the JNK and…”
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Discovery of potent anti–tuberculosis agents targeting aminoacyl–tRNA synthetases by Volynets, G. P., Starosyla, S. A., Bdzhola, V. G., Yarmoluk, S. M., Tukalo, M. A.

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Identification of potential novel membrane drug targets of Acinetobacter baumannii ATCC 19606 using subtractive proteomics approach by Shmatkov, M. V., Volynets, G. P., Bdzhola, V. G., Matiushok, V. I., Chubukov, O. M., Yarmoluk, S. M.

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Non-nucleoside O6-methylguanine-DNA methyltransferase inhibitors in murine spontaneous tumor experimental chemotherapy in vivo by Macewicz, L. L., Zhuvaka, K. S., Papuga, O. Y., Ruban, T. P., Volynets, G. P., Bdzhola, V. G., Yarmoluk, S. M., Lukash, L. L.

“…Alkylating chemotherapy agents are well-established for inducing DNA lesions that result in apoptosis in cancer cells. However, the efficacy of these agents is…”
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