Search Results - "Bazzini, Ariel A."

Upstream ORFs are prevalent translational repressors in vertebrates by Johnstone, Timothy G, Bazzini, Ariel A, Giraldez, Antonio J

“…Regulation of gene expression is fundamental in establishing cellular diversity and a target of natural selection. Untranslated mRNA regions (UTRs) are key…”
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Translation of small downstream ORFs enhances translation of canonical main open reading frames by Wu, Qiushuang, Wright, Matthew, Gogol, Madelaine M, Bradford, William D, Zhang, Ning, Bazzini, Ariel A

“…In addition to canonical open reading frames (ORFs), thousands of translated small ORFs (containing less than 100 codons) have been identified in untranslated…”
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Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition by Lee, Miler T., Bonneau, Ashley R., Takacs, Carter M., Bazzini, Ariel A., DiVito, Kate R., Fleming, Elizabeth S., Giraldez, Antonio J.

“…After fertilization, maternal factors direct development and trigger zygotic genome activation (ZGA) at the maternal-to-zygotic transition (MZT). In zebrafish,…”
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miR-430 regulates zygotic mRNA during zebrafish embryogenesis by Baia Amaral, Danielson, Egidy, Rhonda, Perera, Anoja, Bazzini, Ariel A

“…Early embryonic developmental programs are guided by the coordinated interplay between maternally inherited and zygotically manufactured RNAs and proteins…”
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Brd4 and P300 Confer Transcriptional Competency during Zygotic Genome Activation by Chan, Shun Hang, Tang, Yin, Miao, Liyun, Darwich-Codore, Hiba, Vejnar, Charles E., Beaudoin, Jean-Denis, Musaev, Damir, Fernandez, Juan P., Benitez, Maria D.J., Bazzini, Ariel A., Moreno-Mateos, Miguel A., Giraldez, Antonio J.

“…The awakening of the genome after fertilization is a cornerstone of animal development. However, the mechanisms that activate the silent genome after…”
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Standardized annotation of translated open reading frames by Mudge, Jonathan M., Ruiz-Orera, Jorge, Prensner, John R., Brunet, Marie A., Calvet, Ferriol, Jungreis, Irwin, Gonzalez, Jose Manuel, Magrane, Michele, Martinez, Thomas F., Schulz, Jana Felicitas, Yang, Yucheng T., Albà, M. Mar, Aspden, Julie L., Baranov, Pavel V., Bazzini, Ariel A., Bruford, Elspeth, Martin, Maria Jesus, Calviello, Lorenzo, Carvunis, Anne-Ruxandra, Chen, Jin, Couso, Juan Pablo, Deutsch, Eric W., Flicek, Paul, Frankish, Adam, Gerstein, Mark, Hubner, Norbert, Ingolia, Nicholas T., Kellis, Manolis, Menschaert, Gerben, Moritz, Robert L., Ohler, Uwe, Roucou, Xavier, Saghatelian, Alan, Weissman, Jonathan S., van Heesch, Sebastiaan

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Dengue virus preferentially uses human and mosquito non-optimal codons by Castellano, Luciana A, McNamara, Ryan J, Pallarés, Horacio M, Gamarnik, Andrea V, Alvarez, Diego E, Bazzini, Ariel A

“…Codon optimality refers to the effect that codon composition has on messenger RNA (mRNA) stability and translation level and implies that synonymous codons are…”
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Zika virus non-coding RNAs antagonize antiviral responses by PKR-mediated translational arrest by Pallarés, Horacio M, González López Ledesma, María Mora, Oviedo-Rouco, Santiago, Castellano, Luciana A, Costa Navarro, Guadalupe S, Fernández-Alvarez, Ana J, D’Andreiz, María Josefina, Aldas-Bulos, Victor Daniel, Alvarez, Diego E, Bazzini, Ariel A, Gamarnik, Andrea V

“…Abstract Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that causes severe outbreaks in human populations. ZIKV infection leads to the accumulation…”
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Protein profiling of zebrafish embryos unmasks regulatory layers during early embryogenesis by da Silva Pescador, Gabriel, Baia Amaral, Danielson, Varberg, Joseph M., Zhang, Ying, Hao, Yan, Florens, Laurence, Bazzini, Ariel A.

“…The maternal-to-zygotic transition is crucial in embryonic development, marked by the degradation of maternally provided mRNAs and initiation of zygotic gene…”
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Overexpression of snakin-1 gene enhances resistance to Rhizoctonia solani and Erwinia carotovora in transgenic potato plants by ALMASIA, NATALIA I, BAZZINI, ARIEL A, HOPP, H. ESTEBAN, VAZQUEZ-ROVERE, CECILIA

“…Snakin-1 (SN1), a cysteine-rich peptide with broad-spectrum antimicrobial activity in vitro, was evaluated for its ability to confer resistance to pathogens in…”
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Metabolic and miRNA profiling of TMV infected plants reveals biphasic temporal changes by Bazzini, Ariel A, Manacorda, Carlos A, Tohge, Takayuki, Conti, Gabriela, Rodriguez, Maria C, Nunes-Nesi, Adriano, Villanueva, Sofía, Fernie, Alisdair R, Carrari, Fernando, Asurmendi, Sebastian

“…Plant viral infections induce changes including gene expression and metabolic components. Identification of metabolites and microRNAs (miRNAs) differing in…”
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Translation and mRNA Stability Control by Wu, Qiushuang, Bazzini, Ariel A

“…Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the post-transcriptional process that profoundly impact protein…”
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Optimized CRISPR-RfxCas13d system for RNA targeting in zebrafish embryos by Hernandez-Huertas, Luis, Kushawah, Gopal, Diaz-Moscoso, Alejandro, Tomas-Gallardo, Laura, Moreno-Sanchez, Ismael, da Silva Pescador, Gabriel, Bazzini, Ariel A., Moreno-Mateos, Miguel A.

“…CRISPR-Cas systems have been used to induce DNA mutagenesis for gene function discovery. However, the development of tools to eliminate RNAs provides…”
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Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish by Bazzini, Ariel A., Lee, Miler T., Giraldez, Antonio J.

“…MicroRNAs regulate gene expression through deadenylation, repression, and messenger RNA (mRNA) decay. However, the contribution of each mechanism in…”
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Virus infection elevates transcriptional activity of miR164a promoter in plants by Bazzini, Ariel A, Almasia, Natalia I, Manacorda, Carlos A, Mongelli, Vanesa C, Conti, Gabriela, Maroniche, Guillermo A, Rodriguez, María C, Distéfano, Ana J, Hopp, H Esteban, del Vas, Mariana, Asurmendi, Sebastian

“…Micro RNAs (miRs) constitute a large group of endogenous small RNAs that have crucial roles in many important plant functions. Virus infection and transgenic…”
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Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition by Bazzini, Ariel A, del Viso, Florencia, Moreno-Mateos, Miguel A, Johnstone, Timothy G, Vejnar, Charles E, Qin, Yidan, Yao, Jun, Khokha, Mustafa K, Giraldez, Antonio J

“…Cellular transitions require dramatic changes in gene expression that are supported by regulated mRNA decay and new transcription. The maternal‐to‐zygotic…”
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CRISPR-Cas13d Induces Efficient mRNA Knockdown in Animal Embryos by Kushawah, Gopal, Hernandez-Huertas, Luis, Abugattas-Nuñez del Prado, Joaquin, Martinez-Morales, Juan R., DeVore, Michelle L., Hassan, Huzaifa, Moreno-Sanchez, Ismael, Tomas-Gallardo, Laura, Diaz-Moscoso, Alejandro, Monges, Dahiana E., Guelfo, Javier R., Theune, William C., Brannan, Emry O., Wang, Wei, Corbin, Timothy J., Moran, Andrea M., Sánchez Alvarado, Alejandro, Málaga-Trillo, Edward, Takacs, Carter M., Bazzini, Ariel A., Moreno-Mateos, Miguel A.

“…Early embryonic development is driven exclusively by maternal gene products deposited into the oocyte. Although critical in establishing early developmental…”
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Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation by Bazzini, Ariel A, Johnstone, Timothy G, Christiano, Romain, Mackowiak, Sebastian D, Obermayer, Benedikt, Fleming, Elizabeth S, Vejnar, Charles E, Lee, Miler T, Rajewsky, Nikolaus, Walther, Tobias C, Giraldez, Antonio J

“…Identification of the coding elements in the genome is a fundamental step to understanding the building blocks of living systems. Short peptides (< 100 aa)…”
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Systems to study codon effect on post-transcriptional regulation of gene expression by Wu, Qiushuang, Bazzini, Ariel A.

“…•mRNA translation affects mRNA stability in the codon composition dependent manner.•The genetic code contains strong regulatory information.•Translation…”
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Codon optimality influences homeostatic gene expression in zebrafish by DeVore, Michelle L, Bazzini, Ariel A

“…The ribosome plays a crucial role in translating mRNA into protein; however, the genetic code extends beyond merely specifying amino acids. Upon translation,…”
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