Search Results - "Bazirgan, Omar"

Cue1p Is an Activator of Ubc7p E2 Activity in Vitro and in Vivo by Bazirgan, Omar A., Hampton, Randolph Y.

“…Ubc7p is a ubiquitin-conjugating enzyme (E2) that functions with endoplasmic reticulum (ER)-resident ubiquitin ligases (E3s) to promote endoplasmic…”
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Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization by Smider, Vaughn V, Mao, Hongyuan, Graziano, James J, Chase, Tyson M A, Bentley, Cornelia A, Bazirgan, Omar A, Reddy, Neil P, Song, Byeong Doo

“…Antibodies that modulate the activity of a target are difficult to discover with display-based approaches, which select only high-affinity binders. Mao et al …”
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Arrayed antibody library technology for therapeutic biologic discovery by Bentley, Cornelia A., Bazirgan, Omar A., Graziano, James J., Holmes, Evan M., Smider, Vaughn V.

“…Traditional immunization and display antibody discovery methods rely on competitive selection amongst a pool of antibodies to identify a lead. While this…”
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Determinants of RING-E2 Fidelity for Hrd1p, a Membrane-anchored Ubiquitin Ligase by Bazirgan, Omar A., Garza, Renee M., Hampton, Randolph Y.

“…A critical aspect of E3 ubiquitin ligase function is the selection of a particular E2 ubiquitin-conjugating enzyme to accomplish ubiquitination of a substrate…”
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Cdc48-Ufd2-Rad23: the road less ubiquitinated? by Bazirgan, Omar A, Hampton, Randolph Y

“…Targeting substrates to the proteasome is generally thought to depend on long polyubiquitin chains that form on the substrate. Recent work has led to the…”
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MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis by Srayko, M, Buster, D W, Bazirgan, O A, McNally, F J, Mains, P E

“…The Caenorhabditis elegans meiotic spindle is morphologically distinct from the first mitotic spindle, yet both structures form in the same cytoplasm…”
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Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin by McNally, K P, Bazirgan, O A, McNally, F J

“…The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Some microtubule-binding proteins bind…”
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Advancements in Research Grade Biosimilars Enable the Study of Therapeutic Antibodies by Cantor, Joseph, Gao, Guo-Jian, Rigaud, Stephanie, Wei, Ai-Li, Bazirgan, Omar, Verma, Shilpi

“…Abstract Biosimilars for therapeutic antibodies contain identical variable sequences to FDA-approved antibodies. Recombinant BD research-grade biosimilars can…”
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Reshaping Antibody Diversity by Wang, Feng, Ekiert, Damian C., Ahmad, Insha, Yu, Wenli, Zhang, Yong, Bazirgan, Omar, Torkamani, Ali, Raudsepp, Terje, Mwangi, Waithaka, Criscitiello, Michael F., Wilson, Ian A., Schultz, Peter G., Smider, Vaughn V.

“…Some species mount a robust antibody response despite having limited genome-encoded combinatorial diversity potential. Cows are unusual in having exceptionally…”
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Functional analysis of the ubiquitin ligase Hrd1p with the ubiquitin -conjugating enzyme Ubc7p by Bazirgan, Omar Al-Kasim

“…Ubiquitin is a covalent protein tag that alters the stability or behavior of a growing list of proteins. Covalent attachment of ubiquitin to target proteins…”
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Functional analysis of the ubiquitin ligase Hrd1p with the ubiquitin-conjugating enzyme Ubc7p by Bazirgan, Omar Al-Kasim

“…Ubiquitin is a covalent protein tag that alters the stability or behavior of a growing list of proteins. Covalent attachment of ubiquitin to target proteins…”
Get full text