Search Results - "Bazil, Jason N."

Calcium phosphate precipitation inhibits mitochondrial energy metabolism by Malyala, Sathyavani, Zhang, Yizhu, Strubbe, Jasiel O, Bazil, Jason N

“…Early studies have shown that moderate levels of calcium overload can cause lower oxidative phosphorylation rates. However, the mechanistic interpretations of…”
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Analysis of a Functional Dimer Model of Ubiquinol Cytochrome c Oxidoreductase by Bazil, Jason N.

“…Ubiquinol cytochrome c oxidoreductase (bc1 complex) serves as an important electron junction in many respiratory systems. It funnels electrons coming from NADH…”
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Catalytic Coupling of Oxidative Phosphorylation, ATP Demand, and Reactive Oxygen Species Generation by Bazil, Jason N., Beard, Daniel A., Vinnakota, Kalyan C.

“…Competing models of mitochondrial energy metabolism in the heart are highly disputed. In addition, the mechanisms of reactive oxygen species (ROS) production…”
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Calcium Overload and Mitochondrial Metabolism by Walkon, Lauren L, Strubbe-Rivera, Jasiel O, Bazil, Jason N

“…Mitochondria calcium is a double-edged sword. While low levels of calcium are essential to maintain optimal rates of ATP production, extreme levels of calcium…”
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The mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function by Strubbe-Rivera, Jasiel O., Schrad, Jason R., Pavlov, Evgeny V., Conway, James F., Parent, Kristin N., Bazil, Jason N.

“…Mitochondria have a remarkable ability to uptake and store massive amounts of calcium. However, the consequences of massive calcium accumulation remain…”
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Feedback Regulation and Time Hierarchy of Oxidative Phosphorylation in Cardiac Mitochondria by Vinnakota, Kalyan C., Bazil, Jason N., Van den Bergh, Françoise, Wiseman, Robert W., Beard, Daniel A.

“…To determine how oxidative ATP synthesis is regulated in the heart, the responses of cardiac mitochondria oxidizing pyruvate to alterations in [ATP], [ADP],…”
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Quantification of Mitochondrial Oxidative Phosphorylation in Metabolic Disease: Application to Type 2 Diabetes by Lewis, Matthew T, Kasper, Jonathan D, Bazil, Jason N, Frisbee, Jefferson C, Wiseman, Robert W

“…Type 2 diabetes (T2D) is a growing health concern with nearly 400 million affected worldwide as of 2014. T2D presents with hyperglycemia and insulin resistance…”
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The effect of respiration buffer composition on mitochondrial metabolism and function by Wollenman, Lucas C, Vander Ploeg, Matthew R, Miller, Mackinzie L, Zhang, Yizhu, Bazil, Jason N

“…Functional studies on isolated mitochondria critically rely on the right choice of respiration buffer. Differences in buffer composition can lead to…”
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Analysis of the Kinetics and Bistability of Ubiquinol:Cytochrome c Oxidoreductase by Bazil, Jason N., Vinnakota, Kalyan C., Wu, Fan, Beard, Daniel A.

“…Ubiquinol:cytochrome c oxidoreductase, bc1 complex, is the enzyme in the respiratory chain of mitochondria responsible for the transfer reducing potential from…”
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Postnatal growth restriction alters myocardial mitochondrial energetics in mice by Visker, Joseph R., Leszczynski, Eric C., Wellette‐Hunsucker, Austin G., McPeek, Ashley C., Quinn, Melissa A., Kim, Seong Hyun, Bazil, Jason N., Ferguson, David P.

“…Postnatal growth restriction (PGR) can increase the risk of cardiovascular disease (CVD) potentially due to impairments in oxidative phosphorylation (OxPhos)…”
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Determining the origins of superoxide and hydrogen peroxide in the mammalian NADH:ubiquinone oxidoreductase by Bazil, Jason N., Pannala, Venkat R., Dash, Ranjan K., Beard, Daniel A.

“…NADH:ubiquinone oxidoreductase (complex I) is a proton pump in the electron transport chain that can produce a significant amounts of superoxide and hydrogen…”
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A pH-Dependent Kinetic Model of Dihydrolipoamide Dehydrogenase from Multiple Organisms by Moxley, Michael A., Beard, Daniel A., Bazil, Jason N.

“…Dihydrolipoamide dehydrogenase is a flavoenzyme that reversibly catalyzes the oxidation of reduced lipoyl substrates with the reduction of NAD+ to NADH…”
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Modeling the Effects of Calcium Overload on Mitochondrial Ultrastructural Remodeling by Strubbe-Rivera, Jasiel O, Chen, Jiahui, West, Benjamin A, Parent, Kristin N, Wei, Guo-Wei, Bazil, Jason N

“…Mitochondrial cristae are dynamic invaginations of the inner membrane and play a key role in its metabolic capacity to produce ATP. Structural alterations…”
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A minimal model for the mitochondrial rapid mode of Ca²+ uptake mechanism by Bazil, Jason N, Dash, Ranjan K

“…Mitochondria possess a remarkable ability to rapidly accumulate and sequester Ca²⁺. One of the mechanisms responsible for this ability is believed to be the…”
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Systems-level computational modeling demonstrates fuel selection switching in high capacity running and low capacity running rats by Moxley, Michael A, Vinnakota, Kalyan C, Bazil, Jason N, Qi, Nathan R, Beard, Daniel A

“…High capacity and low capacity running rats, HCR and LCR respectively, have been bred to represent two extremes of running endurance and have recently…”
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The Role of Swelling in the Regulation of OPA1-Mediated Mitochondrial Function in the Heart In Vitro by Chapa-Dubocq, Xavier R, Rodríguez-Graciani, Keishla M, García-Báez, Jorge, Vadovsky, Alyssa, Bazil, Jason N, Javadov, Sabzali

“…Optic atrophy-1 (OPA1) plays a crucial role in the regulation of mitochondria fusion and participates in maintaining the structural integrity of mitochondrial…”
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Modeling mitochondrial bioenergetics with integrated volume dynamics by Bazil, Jason N, Buzzard, Gregery T, Rundell, Ann E

“…Mathematical models of mitochondrial bioenergetics provide powerful analytical tools to help interpret experimental data and facilitate experimental design for…”
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The inferred cardiogenic gene regulatory network in the mammalian heart by Bazil, Jason N, Stamm, Karl D, Li, Xing, Thiagarajan, Raghuram, Nelson, Timothy J, Tomita-Mitchell, Aoy, Beard, Daniel A

“…Cardiac development is a complex, multiscale process encompassing cell fate adoption, differentiation and morphogenesis. To elucidate pathways underlying this…”
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A Biophysical Model of the Mitochondrial ATP-Mg/Pi Carrier by Tewari, Shivendra G., Dash, Ranjan K., Beard, Daniel A., Bazil, Jason N.

“…Mitochondrial adenine nucleotide (AdN) content is regulated through the Ca2+-activated, electroneutral ATP-Mg/Pi carrier (APC). The APC is a protein in the…”
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Human Cardiac 31P-MR Spectroscopy at 3 Tesla Cannot Detect Failing Myocardial Energy Homeostasis during Exercise by Bakermans, Adrianus J., Bazil, Jason N., Nederveen, Aart J., Strijkers, Gustav J., Boekholdt, S. Matthijs, Beard, Daniel A., Jeneson, Jeroen A. L.

“…Phosphorus-31 magnetic resonance spectroscopy ( 31 P-MRS) is a unique non-invasive imaging modality for probing in vivo high-energy phosphate metabolism in the…”
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