The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases

The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases

MicroRNAs (miRNAs) are a group of small non-coding RNAs that regulate gene expression by targeting mRNA. Moreover, it has been shown that miRNAs expression are changed in various diseases, such as cancers, autoimmune disease, infectious diseases, and neurodegenerative Diseases. The suppression of mi...

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Bibliographic Details
Published in:Cell communication and signaling Vol. 21; no. 1; p. 20
Main Authors: Oveili, Elham, Vafaei, Somayeh, Bazavar, Haniyeh, Eslami, Yeganeh, Mamaghanizadeh, Ehsan, Yasamineh, Saman, Gholizadeh, Omid
Format: Journal Article
Language:English
Published: England BioMed Central 23-01-2023
BMC
Subjects:
Apoptosis
Autoimmune diseases
Biosynthesis
Cell cycle
Drug delivery system
Exosomes
Exosomes - metabolism
Gene expression
Good Manufacturing Practice
Infectious diseases
Membranes
Mesenchymal stem cells
Mesenchymal Stem Cells - metabolism
MicroRNAs
MicroRNAs - genetics
miRNA
Neurodegenerative diseases
Non-coding RNA
Plasma
Proteins
Review
RNA polymerase
Signal transduction
Stem cells
Exosomes
Drug delivery system
Non-coding RNA
Mesenchymal stem cells
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Summary:MicroRNAs (miRNAs) are a group of small non-coding RNAs that regulate gene expression by targeting mRNA. Moreover, it has been shown that miRNAs expression are changed in various diseases, such as cancers, autoimmune disease, infectious diseases, and neurodegenerative Diseases. The suppression of miRNA function can be easily attained by utilizing of anti-miRNAs. In contrast, an enhancement in miRNA function can be achieved through the utilization of modified miRNA mimetics. The discovery of appropriate miRNA carriers in the body has become an interesting subject for investigators. Exosomes (EXOs) therapeutic efficiency and safety for transferring different cellular biological components to the recipient cell have attracted significant attention for their capability as miRNA carriers. Mesenchymal stem cells (MSCs) are recognized to generate a wide range of EXOs (MSC-EXOs), showing that MSCs may be effective for EXO generation in a clinically appropriate measure as compared to other cell origins. MSC-EXOs have been widely investigated because of their immune attributes, tumor-homing attributes, and flexible characteristics. In this article, we summarized the features of miRNAs and MSC-EXOs, including production, purification, and miRNA loading methods of MSC-EXOs, and the modification of MSC-EXOs for targeted miRNA delivery in various diseases. Video abstract.
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ISSN:1478-811X
1478-811X
DOI:10.1186/s12964-022-01017-9