Search Results - "Bazan Peregrino, M."

Combining virotherapy and angiotherapy for the treatment of breast cancer by Bazan-Peregrino, M, Sainson, R C A, Carlisle, R C, Thoma, C, Waters, R A, Arvanitis, C, Harris, A L, Hernandez-Alcoceba, R, Seymour, L W

“…A breast cancer-selective oncolytic adenovirus was engineered to express antagonists of vascular endothelial growth factor (VEGF) and Notch signaling to…”
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Factors influencing retention of adenovirus within tumours following direct intratumoural injection by Bazan-Peregrino, M, Carlisle, R C, Purdie, L, Seymour, L W

“…Direct intratumoural (IT) administration of adenovirus is widely used, however little is known about the resulting distribution of virus particles. Here we…”
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Gene therapy targeting to tumor endothelium by Bazan-Peregrino, M, Seymour, L W, Harris, A L

“…Tumor-associated vasculature is a relatively accessible component of solid cancers that is essential for tumor survival and growth, providing a vulnerable…”
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Comparison of molecular strategies for breast cancer virotherapy using oncolytic adenovirus by Bazan-Peregrino, M, Carlisle, R C, Hernandez-Alcoceba, R, Iggo, R, Homicsko, K, Fisher, K D, Halldén, G, Mautner, V, Shen, Y, Seymour, L W

“…Oncolytic viruses are regulated by the tumor phenotype to replicate and lyse cancer cells selectively. To identify optimal strategies for breast cancer we…”
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2271P Development of an oncolytic virus for the treatment of high grade serous ovarian cancer and other stromal rich tumours by Peregrino, M. Bazan, Frost, S.C., Negroni, C., Moriconi, C., Perry, T., Taverner, W., Nicholls, B., Saunders, D., Ackerman-Johnson, R., Cunnea, P., Fotopoulou, C., Krell, J., Lim, A., Fisher, K., Duffy, M.R.

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Increased antitumour activity and extravasation of immune checkpoint inhibitor due to hyaluronidase expressed from oncolytic adenovirus VCN-01 and generation of new viruses with improved hyaluronidase activity by Farrera, M., Mato-Berciano, A., Morgado, S., Moreno, R., de Sostoa Pomes, J., Alemany, R., Bazan-Peregrino, M.

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94PIncreased antitumour activity and extravasation of immune checkpoint inhibitor due to hyaluronidase expressed from oncolytic adenovirus VCN-01 and generation of new viruses with improved hyaluronidase activity by Farrera, M, Mato-Berciano, A, Morgado, S, Moreno, R, de Sostoa Pomes, J, Alemany, R, Bazan-Peregrino, M

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1231P Phase I study to evaluate the safety, tolerability, and efficacy of VCN-01 in combination with durvalumab (MEDI4736) in subjects with recurrent/metastatic squamous cell carcinoma of the head and neck (R/M HNSCC) by Jove, M., Brana, I., Oliva Bernal, M., Hernando-Calvo, A., Erasun Lecuona, C., Assaf Pastrana, J.D., Bazan Peregrino, M., Mato-Berciano, A., Maliandi, M.V., Torres-Manjon, S., Martinez de Villareal, J., Real, F.X., Nuciforo, P.G., Alemany, R., Capella, G., Blasi, E., Blasco, C., Cascallo Piqueras, M., Mesia Nin, R.

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Oncolytic adenovirus expressing tumor neoepitopes as a vaccine by Sal, M Farrera, Moreno, R., de Sostoa Pomés, J., Arias-Badia, M., Fajardo, C.A., Al-Zaher, A., Bazan-Peregrino, M., Alemany, R.

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Proof of concept clinical study by US-guided intratumor injection of VCN-01, an oncolytic adenovirus expressing hyaluronidase in patients with pancreatic cancer by Hidalgo, M., Bazan-Peregrino, M., Laquente, B., Gallego, R Alvarez, Mato-Berciano, A., Giménez-Alejandre, M., Maliandi, V., Martinez, M C Riesco, Moreno, R., Morell, M., Perez-Carreras, M., Gornals, J., Prados, S., Capella, G., Alemany, R., Salazar, R., Blasi, E., Blasco, C., Cascallo, M., Garcia-Carbonero, R.

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459P - Proof of concept clinical study by US-guided intratumor injection of VCN-01, an oncolytic adenovirus expressing hyaluronidase in patients with pancreatic cancer by Hidalgo, M., Bazan-Peregrino, M., Laquente, B., Gallego, R Alvarez, Mato-Berciano, A., Giménez-Alejandre, M., Maliandi, V., Martinez, M C Riesco, Moreno, R., Morell, M., Perez-Carreras, M., Gornals, J., Prados, S., Capella, G., Alemany, R., Salazar, R., Blasi, E., Blasco, C., Cascallo, M., Garcia-Carbonero, R.

“…Dense stroma is a hallmark of hard-to-treat cancers such as pancreatic adenocarcinoma. VCN-01 oncolytic adenovirus is designed to replicate in cancer cells…”
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Systemic administration of the hyaluronidase-expressing oncolytic adenovirus VCN-01 in patients with advanced or metastatic pancreatic cancer: First-in-human clinical trial by Garcia-Carbonero, R., Gil Martín, M., Alvarez Gallego, R., Macarulla Mercade, T., Riesco Martinez, M.C., Guillen-Ponce, C., Vidal, N., Real, F.X., Moreno, R., Maliandi, V., Mato-Berciano, A., Bazan-Peregrino, M., Capella, G., Alemany, R., Blasi, E., Blasco, C., Cascallo, M., Salazar, R.

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710P - Systemic administration of the hyaluronidase-expressing oncolytic adenovirus VCN-01 in patients with advanced or metastatic pancreatic cancer: First-in-human clinical trial by Garcia-Carbonero, R., Gil Martín, M., Alvarez Gallego, R., Macarulla Mercade, T., Riesco Martinez, M.C., Guillen-Ponce, C., Vidal, N., Real, F.X., Moreno, R., Maliandi, V., Mato-Berciano, A., Bazan-Peregrino, M., Capella, G., Alemany, R., Blasi, E., Blasco, C., Cascallo, M., Salazar, R.

“…Expression of hyaluronidase from the selective oncolytic adenovirus VCN-01 modifies tumor matrix in pancreatic tumours. Such effect enhances gemcitabine uptake…”
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459PProof of concept clinical study by US-guided intratumor injection of VCN-01, an oncolytic adenovirus expressing hyaluronidase in patients with pancreatic cancer by Hidalgo, M, Bazan-Peregrino, M, Laquente, B, Gallego, R Alvarez, Mato-Berciano, A, Giménez-Alejandre, M, Maliandi, V, Martinez, M C Riesco, Moreno, R, Morell, M, Perez-Carreras, M, Gornals, J, Prados, S, Capella, G, Alemany, R, Salazar, R, Blasi, E, Blasco, C, Cascallo, M, Garcia-Carbonero, R

“…Abstract Background Dense stroma is a hallmark of hard-to-treat cancers such as pancreatic adenocarcinoma. VCN-01 oncolytic adenovirus is designed to replicate…”
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710PSystemic administration of the hyaluronidase-expressing oncolytic adenovirus VCN-01 in patients with advanced or metastatic pancreatic cancer: First-in-human clinical trial by Garcia-Carbonero, R, Gil Martín, M, Alvarez Gallego, R, Macarulla Mercade, T, Riesco Martinez, M C, Guillen-Ponce, C, Vidal, N, Real, F X, Moreno, R, Maliandi, V, Mato-Berciano, A, Bazan-Peregrino, M, Capella, G, Alemany, R, Blasi, E, Blasco, C, Cascallo, M, Salazar, R

“…Abstract Background Expression of hyaluronidase from the selective oncolytic adenovirus VCN-01 modifies tumor matrix in pancreatic tumours. Such effect…”
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Cavitation-enhanced delivery of macromolecules into an obstructed vessel by Rifai, Bassel, Arvanitis, Costas D., Bazan-Peregrino, Miriam, Coussios, Constantin-C.

“…Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The aim of this study was to examine the ability of…”
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