Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling

Fundamental studies of molecular and cellular mechanisms of cardiovascular disease pathogenesis are required to create more effective and safer methods of their therapy. The studies can be carried out only when model systems that fully recapitulate pathological phenotype seen in patients are used. A...

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Bibliographic Details
Published in:Cardiology research and practice Vol. 2016; no. 2016; pp. 1 - 17
Main Authors: Zakian, Suren M., Pokushalov, Evgeny A., Bayramova, Sevda A., Dementyeva, Elena V., Medvedev, Sergey P., Bayzigitov, Daniel R., Karaskov, Alexander M.
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2016
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Analgesics
Biopsy
Cardiac arrhythmia
Cardiomyocytes
Cardiovascular disease
Cardiovascular diseases
Complications and side effects
Congenital diseases
Dopamine
Drug dosages
Gene expression
Heart attacks
Heart cells
Heart failure
Heart rate
Histamine
Laboratory animals
Medical research
Medicine, Experimental
Mutation
Narcotics
Pathogenesis
Patients
Pharmaceutical industry
Physiology
Precision medicine
Psychotropic drugs
Review
Serotonin
Stem cells
Stroke
United States > US
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Summary:Fundamental studies of molecular and cellular mechanisms of cardiovascular disease pathogenesis are required to create more effective and safer methods of their therapy. The studies can be carried out only when model systems that fully recapitulate pathological phenotype seen in patients are used. Application of laboratory animals for cardiovascular disease modeling is limited because of physiological differences with humans. Since discovery of induced pluripotency generating induced pluripotent stem cells has become a breakthrough technology in human disease modeling. In this review, we discuss a progress that has been made in modeling inherited arrhythmias and cardiomyopathies, studying molecular mechanisms of the diseases, and searching for and testing drug compounds using patient-specific induced pluripotent stem cell-derived cardiomyocytes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Academic Editor: Vicky A. Cameron
ISSN:2090-8016
2090-0597
2090-0597
DOI:10.1155/2016/3582380