Search Results - "Baynes, J W"

Maillard reaction products in tissue proteins: New products and new perspectives by Thorpe, S. R, Baynes, J. W

“…The chemical modification of protein by nonenzymatic browning or Maillard reactions increases with age and in disease. Maillard products are formed by…”
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Role of oxidative stress in diabetic complications: a new perspective on an old paradigm by BAYNES, J. W, THORPE, S. R

“…Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. J W Baynes and S R Thorpe Department of Chemistry and Biochemistry,…”
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Simple non-invasive assessment of advanced glycation endproduct accumulation by MEERWALDT, R, GRAAFF, R, OOMEN, P. H. N, LINKS, T. P, JAGER, J. J, ALDERSON, N. L, THORPE, S. R, BAYNES, J. W, GANS, R. O. B, SMIT, A. J

“…The accumulation of AGE is thought to play a role in the pathogenesis of chronic complications of diabetes mellitus and renal failure. All current measurements…”
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The role of AGEs in aging: causation or correlation by Baynes, John W.

“…Over a dozen advanced glycation end-products (AGEs) have been identified in tissue proteins by chemical or immunological methods. Of these, about half are…”
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Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy by MEERWALDT, R, LINKS, T. P, GRAAFF, R, HOOGENBERG, K, LEFRANDT, J. D, BAYNES, J. W, GANS, R. O. B, SMIT, A. J

“…The accumulation of AGE is related to the progression of the renal, retinal and vascular complications of diabetes. However, the relationship with diabetic…”
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Role of oxidative stress in development of complications in diabetes by Baynes, J. W.

“…Role of oxidative stress in development of complications in diabetes. J W Baynes Department of Chemistry, University of South Carolina, Columbia 29208…”
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Alterations in nonenzymatic biochemistry in uremia: Origin and significance of “carbonyl stress” in long-term uremic complications by Miyata, Toshio, van Ypersele de Strihou, Charles, Kurokawa, Kiyoshi, Baynes, John W.

“…Alterations in non-enzymatic biochemistry in uremia: Origin and significance of “carbonyl stress” in long-term uremic complications. Advanced glycation end…”
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Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat by ALDERSON, N. L, CHACHICH, M. E, FRIZZELL, N, CANNING, P, METZ, T. O, JANUSZEWSKI, A. S, YOUSSEF, N. N, STITT, A. W, BAYNES, J. W, THORPE, S. R

“…This study was designed to determine whether inhibition of formation of AGE and advanced lipoxidation end-products (ALE) is a mechanism of action common to a…”
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Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes by Yu, Y, Thorpe, S. R, Jenkins, A. J, Shaw, J. N, Sochaski, M. A, McGee, D, Aston, C. E, Orchard, T. J, Silvers, N, Peng, Y. G, McKnight, J. A, Baynes, J. W, Lyons, T. J

“…Aims/hypothesis We determined whether oxidative damage in collagen is increased in (1) patients with diabetes; (2) patients with diabetic complications; and…”
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The role of AGEs and AGE inhibitors in diabetic cardiovascular disease by Thomas, M C, Baynes, J W, Thorpe, S R, Cooper, M E

“…Prolonged hyperglycemia, dyslipidemia and oxidative stress in diabetes result in the production and accumulation of AGEs. It is now clear that AGEs contribute…”
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Role of oxidative stress in development of complications in diabetes by BAYNES, J. W

“…N epsilon-(carboxymethyl)lysine, N epsilon-(carboxymethyl)hydroxylysine, and the fluorescent cross-link pentosidine are formed by sequential glycation and…”
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Age-related accumulation of Maillard reaction products in human articular cartilage collagen by Verzijl, N, DeGroot, J, Oldehinkel, E, Bank, R A, Thorpe, S R, Baynes, J W, Bayliss, M T, Bijlsma, J W, Lafeber, F P, Tekoppele, J M

“…Non-enzymic modification of tissue proteins by reducing sugars, the so-called Maillard reaction, is a prominent feature of aging. In articular cartilage,…”
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Advanced glycation end products and the absence of premature atherosclerosis in glycogen storage disease Ia by den Hollander, N. C, Mulder, D. J, Graaff, R, Thorpe, S. R, Baynes, J. W, Smit, G. P. A, Smit, A. J

“…Introduction Despite their unfavourable cardiovascular risk profile, patients with glycogen storage disease type Ia (GSD Ia) do not develop premature…”
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Glycation, glycoxidation, and cross-linking of collagen by glucose. Kinetics, mechanisms, and inhibition of late stages of the Maillard reaction by Fu, M. X., Wells-Knecht, K. J., Blackledge, J. A., Lyons, T. J., Thorpe, S. R., Baynes, J. W.

“…Glycation, glycoxidation, and cross-linking of collagen by glucose. Kinetics, mechanisms, and inhibition of late stages of the Maillard reaction. M X Fu , K J…”
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Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy : effect of angiotensin-converting enzyme and vasopeptidase inhibition by WIHLER, C, SCHÄFER, S, HUBER, J, SCHMID, K, DEEMER, E. K, MÜNCH, G, BLEICH, M, BUSCH, A. E, DINGERMANN, T, SOMOZA, V, BAYNES, J. W

“…Renal accumulation of AGEs may contribute to the progression of diabetic nephropathy. We evaluated the effect of ramipril (a pure ACE inhibitor) and AVE7688 (a…”
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Accumulation of Maillard reaction products in skin collagen in diabetes and aging by DYER, D. G, DUNN, J. A, THORPE, S. R, BAILIE, K. E, LYONS, T. J, MCCANCE, D. R, BAYNES, J. W

“…To investigate the contribution of glycation and oxidation reactions to the modification of insoluble collagen in aging and diabetes, Maillard reaction…”
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Chemical modification of proteins by methylglyoxal by Degenhardt, T P, Thorpe, S R, Baynes, J W

“…Methylglyoxal is formed in vivo by spontaneous decomposition of triose phosphate intermediates in aerobic glycolysis. It may also be formed during oxidative…”
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New biomarkers of Maillard reaction damage to proteins by WELLS-KNECHT, K. J, BRINKMANN, E, WELLS-KNECHT, M. C, LITCHFIELD, J. E, AHMED, M. U, REDDY, S, ZYZAK, D. V, THORPE, S. R, BAYNES, J. W

“…The amount of advanced glycation end-products (AGE) in tissue proteins increases in diabetes mellitus, and the concentration of a subclass of AGEs, known as…”
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Role of lipids in chemical modification of proteins and development of complications in diabetes by Januszewski, A S, Alderson, N L, Metz, T O, Thorpe, S R, Baynes, J W

“…Hyperglycaemia is the major risk factor for the development of complications in both Type I and Type II diabetes; however, there is growing evidence from…”
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Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo by DYER, D. G, BLACKLEDGE, J. A, THORPE, S. R, BAYNES, J. W

“…A fluorescent compound has been detected in proteins browned during Maillard reactions with glucose in vitro and shown to be identical to pentosidine, a…”
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