Search Results - "Bayne, Ellen K."

Impaired Neuropathic Pain Responses in Mice Lacking the Chemokine Receptor CCR2 by Abbadie, Catherine, Lindia, Jill A., Cumiskey, Anne Marie, Peterson, Larry B., Mudgett, John S., Bayne, Ellen K., DeMartino, Julie A., MacIntyre, D. Euan, Forrest, Michael J.

“…Mice lacking the chemokine receptor chemotactic cytokine receptor 2 (CCR2) have a marked attenuation of monocyte recruitment in response to various…”
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Aggrecan degradation in osteoarthritis and rheumatoid arthritis by Lark, M W, Bayne, E K, Lohmander, L S

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Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints by Lark, M W, Bayne, E K, Flanagan, J, Harper, C F, Hoerrner, L A, Hutchinson, N I, Singer, I I, Donatelli, S A, Weidner, J R, Williams, H R, Mumford, R A, Lohmander, L S

“…To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control and diseased human articular cartilage, metabolic fragments of aggrecan…”
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Kinetics of aggrecanase‐ and metalloproteinase‐induced neoepitopes in various stages of cartilage destruction in murine arthritis by Van Meurs, Joyce B. J., Van Lent, Peter L. E. M., Holthuysen, Astrid E. M., Singer, Irwin I., Bayne, Ellen K., Van Den Berg, Wim B.

“…Objective Two major cleavage sites, one mediated by metalloproteinases (MMPs) and the other by an as‐yet unidentified enzyme termed aggrecanase, have been…”
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Immunohistochemical localization of types 1 and 2 5α-reductase in human scalp by BAYNE, E. K, FLANAGAN, J, HARRIS, G, EINSTEIN, M, AYALA, J, CHANG, B, AZZOLINA, B, WHITING, D. A, MUMFORD, R. A, THIBOUTOT, D, SINGER, I. I

“…The predominant form of 5α‐reductase (5aR) in human scalp is 5aR1. None the less, clinical studies have shown that finasteride, a selective inhibitor of 5aR2,…”
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The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy by Singer, I I, Scott, S, Chin, J, Bayne, E K, Limjuco, G, Weidner, J, Miller, D K, Chapman, K, Kostura, M J

“…Interleukin-1 beta (IL-1 beta)-converting enzyme (ICE) is a novel cysteine protease that cleaves the 31-kD inactive cytoplasmic IL-1 beta precursor into active…”
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Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis by van Meurs, J B, van Lent, P L, Singer, I I, Bayne, E K, van de Loo, F A, van den Berg, W B

“…To investigate the relationship between occurrence of the matrix metalloproteinase-generated neoepitope VDIPEN and proteoglycan (PG) loss in arthritis, and to…”
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Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis by Singer, Irwin I., Scott, Sol, Kawka, Douglas W., Bayne, Ellen K., Weidner, Jeffrey R., Williams, Hollis R., Mumford, Richard A., Lark, Michael W., McDonnell, Joseph, Christen, Amy J., Moore, Vernon L., Mudgett, John S., Visco, Denise M.

“…Summary To analyze the roles of two classes of proteinases, ‘aggrecanase’, and matrix metalloproteinases (MMPs), in chondrodestruction during murine…”
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VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis by Singer, I I, Kawka, D W, Bayne, E K, Donatelli, S A, Weidner, J R, Williams, H R, Ayala, J M, Mumford, R A, Lark, M W, Glant, T T

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In vivo effects of stromelysin on the composition and physical properties of rabbit articular cartilage in the presence and absence of a synthetic inhibitor by Bonassar, L J, Jeffries, K A, Frank, E H, Moore, V L, Lark, M W, Bayne, E K, McDonnell, J, Olszewski, J, Hagmann, W, Chapman, K

“…To characterize the effects of intraarticular injection of recombinant human stromelysin (SLN) on the matrix composition and physical properties of cartilage…”
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Production, purification and characterization of canine prostromelysin by Bayne, E K, Hutchinson, N I, Walakovits, L A, Donatelli, S, MacNaul, K L, Harper, C F, Cameron, P, Moore, V L, Lark, M W

“…One of the best studied animal models of osteoarthritis is a dog model in which the anterior cruciate ligament of the hind limb stifle joint is transected…”
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Extracellular matrix-cytoskeletal interactions in rheumatoid arthritis. I. Immunoelectron microscopic analysis of the fibronexus at the adhesive surface of normal porcine type B synoviocytes in vitro by Singer, I I, Kazazis, D M, Kawka, D W, Rupp, E A, Bayne, E K

“…We studied cell surface interactions between the fibronectin (FN)-containing extracellular matrix and the actin cytoskeleton of normal porcine synoviocytes in…”
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