Search Results - "Bayly, Suzanne F."

Quantity of partial agonist activity for antiglucocorticoids complexed with mutant glucocorticoid receptors is constant in two different transactivation assays but not predictable from steroid structure by Sarlis, Nicholas J, Bayly, Suzanne F, Szapary, Daniele, Simons, S.Stoney

“…An unsolved question in steroid hormone action is why the amount of agonist activity displayed by antisteroids is not constant but varies with the assay…”
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2,5-oligoadenylate-peptide nucleic acids (2-5A-PNAs) activate RNase L by Verheijen, J C, van der Marel, G A, van Boom, J H, Bayly, S F, Player, M R, Torrence, P F

“…To potentiate the 2-5A (2',5'-oligoadenylate)-antisense and peptide nucleic acid (PNA) approaches to regulation of gene expression, composite molecules were…”
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2-Methyladenosine-substituted 2', 5'-oligoadenylates : Conformations, 2-5A binding and catalytic activities with human ribonuclease L by KITADE, Y, WAKANA, M, TSUBOI, T, YATOME, C, BAYLY, S. F, PLAYER, M. R, TORRENCE, P. F

“…2-Methyladenosine-substituted analogues of 2-5A, p5'A2'p5'A2'p5'(me2A), p5'(me2A)2'p5'A2'p5'A, and p5'(me2A) 2'p5'(me2A)2'pS'(me2A), were prepared via a…”
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Incorporation of a 4-hydroxy-n-acetylprolinol nucleotide analogue improves the 3'-exonuclease stability of 2'-5'-oligoadenylate-antisense conjugates by VERHEIJEN, J. C, VAN ROON, A.-M. M, MEEUWENOORD, N. J, STUIVENBERG, H. R, BAYLY, S. F, LING CHEN, VAN DER MAREL, G. A, TORRENCE, P. F, VAN BOOM, J. H

“…Incorporation of a 4-hydroxy-N-acetylprolinol nucleotide analogue at the 3'-terminus of DNA or 2-5A-DNA sequences resulted in a significantly enhanced…”
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Chemistry and biochemistry of 2',5'-oligoadenylate-based antisense strategy by Adah, S A, Bayly, S F, Cramer, H, Silverman, R H, Torrence, P F

“…This review describes the application of a natural defense mechanism to develop effective agents for the post-transcriptional control of gene expression. 2-5A…”
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Probing the activation site of ribonuclease L with new N6-substituted 2′,5′-adenylate trimers by Münch, Ursula, Chen, Ling, Bayly, Suzanne F, Torrence, Paul F

“…2-5A trimer [5′-monophosphoryladenylyl(2′-5′)adenylyl(2′-5′)adenosine] activates RNase L. While the 5′-terminal and 2′-terminal adenosine N 6-amino groups play…”
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Ribonuclease L, a 2-5A-Dependent Enzyme: Purification to Homogeneity and Assays for 2-5A Binding and Catalytic Activity by Player, Mark R., Wondrak, Ewald M., Bayly, Suzanne F., Torrence, Paul F.

“…RNase L is a latent endonuclease found in reptiles, birds, and mammals. It is activated by the 2′,5′-phosphodiester-linked oligoadenylates called 2-5A and has…”
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Convergent synthesis of ribonuclease L-active 2′,5′-oligoadenylate-peptide nucleic acids by Wang, Zhengfu, Chen, Ling, Bayly, Suzanne F., Torrence, Paul F.

“…2-5A was conjugated to N-(2-aminoethyl)-glycyl PNA by periodate oxidization, followed by coupling with amino-derivatized PNA and final cyanoborohydride…”
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Synthesis and RNase L Binding and Activation of a 2-5A-(5′)-DNA-(3′)-PNA Chimera, a Novel Potential Antisense Molecule by Verheijen, Jeroen C., Chen, Ling, Bayly, Suzanne F., Torrence, Paul F., van der Marel, Gijsbert A., Van Boom, J. H.

“…Fully automated solid-phase synthesis gave access to a hybrid in which 5′-phosphorylated-2′-5′-linked oligoadenylate (2-5A) is connected to the 5′-terminus of…”
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Testicular signaling: incoming and outgoing messages by Robaire, B, Bayly, S F

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The role of androgens in the regulation of the hypothalamo-pituitary-testicular axis by Bayly, Suzanne F

“…The importance of discontinuous hormonal signals in endocrine communications is suggested by the ability of sustained hormonal signals to shut down, as opposed…”
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