Diurnal Weight Gain in Chronic Psychosis

We found diurnal weight gain to be abnormal among 93 chronically psychotic patients, most of whom had schizophrenia. They were weighed at 7 a.m. and 4 p.m. weekly for 3 weeks. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multip...

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Bibliographic Details
Published in:	Schizophrenia bulletin Vol. 15; no. 3; pp. 501 - 506
Main Authors:	Vieweg, W. Victor R., Godleski, Linda S., Graham, Patricia, Kellogg, Elizabeth J., Goldman, Fran, Barber, Jack, Bayliss, E. Virginia, Glick, Joseph L., Hundley, Paul L., Yank, Glenn R.
Format:	Journal Article
Language:	English
Published:	Oxford National Institute of Mental Health 1989 Oxford University Press
Subjects:	Adult Adult and adolescent clinical studies Antipsychotic Agents - pharmacology Biological and medical sciences Body Weight Chronic Disease Chronic Psychosis Circadian Rhythm Etiology Female Fluid Intake Human Humans Male Medical sciences Middle Aged Psychiatric Patients Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic Disorders - complications Psychotic Disorders - physiopathology Schizophrenia Water-Electrolyte Imbalance - complications Weight Gain Weight Gain - drug effects Human Psychosis Chronic Neuroleptic Psychotropic Body weight Schizophrenia Antipsychotic Blood pressure Sleep wake cycle Personality disorder
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Summary:	We found diurnal weight gain to be abnormal among 93 chronically psychotic patients, most of whom had schizophrenia. They were weighed at 7 a.m. and 4 p.m. weekly for 3 weeks. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multiplying the difference by 100, and dividing the result by the 7 a.m. weight. NDWG was 1.7 ± 1.0 percent for the study sample, 0.6 ± 0.4 percent for 16 acutely psychotic controls, and 0.5 ± 0.4 percent for 29 normals. More than 60 percent of the study sample had abnormal NDWG values. NDWG related to antipsychotic drug dose (r = 0.290, p = 0.005) with variability in drug dose accounting for 8 percent of the variability in NDWG. This report provides yet another piece of evidence that disordered water balance is common in chronic psychiatric patients. The etiology is unknown, but it may relate to subtle brain abnormalities in the regulation of fluid intake and excretion.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0586-7614 1745-1701
DOI:	10.1093/schbul/15.3.501